Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Thomas Trappenberg"'
Autor:
Abraham Nunes, Selena Singh, Jared Allman, Suzanna Becker, Abigail Ortiz, Thomas Trappenberg, Martin Alda
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Bipolar disorder (BD) is a mood disorder involving recurring (hypo)manic and depressive episodes. The inherently temporal nature of BD has inspired its conceptualization using dynamical systems theory, which is a mathematical framework for u
Externí odkaz:
https://doaj.org/article/0c13b98dda524098b36367453dbf3ac5
Publikováno v:
Brain Sciences, Vol 13, Iss 11, p 1562 (2023)
Subanaesthetic doses of ketamine increase γ oscillation power in neural activity measured using electroencephalography (EEG), and this effect lasts several hours after ketamine administration. The mechanisms underlying this effect are unknown. Using
Externí odkaz:
https://doaj.org/article/2bfa5e8903d44c5a8131d6337d67a16f
Publikováno v:
BMC Ecology and Evolution, Vol 21, Iss 1, Pp 1-11 (2021)
Abstract Background Plankton are foundational to marine food webs and an important feature for characterizing ocean health. Recent developments in quantitative imaging devices provide in-flow high-throughput sampling from bulk volumes—opening new e
Externí odkaz:
https://doaj.org/article/0dd4e815c310497ba630b6838a88af6e
Autor:
Abraham Nunes, William Stone, Raffaella Ardau, Anne Berghöfer, Alberto Bocchetta, Caterina Chillotti, Valeria Deiana, Franziska Degenhardt, Andreas J. Forstner, Julie S. Garnham, Eva Grof, Tomas Hajek, Mirko Manchia, Manuel Mattheisen, Francis McMahon, Bruno Müller-Oerlinghausen, Markus M. Nöthen, Marco Pinna, Claudia Pisanu, Claire O’Donovan, Marcella D. C. Rietschel, Guy Rouleau, Thomas Schulze, Giovanni Severino, Claire M. Slaney, Alessio Squassina, Aleksandra Suwalska, Gustavo Turecki, Rudolf Uher, Petr Zvolsky, Pablo Cervantes, Maria del Zompo, Paul Grof, Janusz Rybakowski, Leonardo Tondo, Thomas Trappenberg, Martin Alda
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Predicting lithium response (LiR) in bipolar disorder (BD) may inform treatment planning, but phenotypic heterogeneity complicates discovery of genomic markers. We hypothesized that patients with “exemplary phenotypes”—those whose clin
Externí odkaz:
https://doaj.org/article/148507cd1abd48b0b4092cfa43da61f1
Autor:
William Stone, Abraham Nunes, Kazufumi Akiyama, Nirmala Akula, Raffaella Ardau, Jean-Michel Aubry, Lena Backlund, Michael Bauer, Frank Bellivier, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Cristiana Cruceanu, Alexandre Dayer, Franziska Degenhardt, Maria Del Zompo, Andreas J. Forstner, Mark Frye, Janice M. Fullerton, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto, Liping Hou, Esther Jiménez, Tadafumi Kato, John Kelsoe, Sarah Kittel-Schneider, Po-Hsiu Kuo, Ichiro Kusumi, Catharina Lavebratt, Mirko Manchia, Lina Martinsson, Manuel Mattheisen, Francis J. McMahon, Vincent Millischer, Philip B. Mitchell, Markus M. Nöthen, Claire O’Donovan, Norio Ozaki, Claudia Pisanu, Andreas Reif, Marcella Rietschel, Guy Rouleau, Janusz Rybakowski, Martin Schalling, Peter R. Schofield, Thomas G. Schulze, Giovanni Severino, Alessio Squassina, Julia Veeh, Eduard Vieta, Thomas Trappenberg, Martin Alda
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Predicting lithium response prior to treatment could both expedite therapy and avoid exposure to side effects. Since lithium responsiveness may be heritable, its predictability based on genomic data is of interest. We thus evaluate the degre
Externí odkaz:
https://doaj.org/article/3122c8062c9b4f39a9a4aa0e6220ae8c
Autor:
Abraham Nunes, Thomas Trappenberg, Martin Alda, international Consortium on Lithium Genetics (ConLiGen)
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0225353 (2020)
The Alda score is commonly used to quantify lithium responsiveness in bipolar disorder. Most often, this score is dichotomized into "responder" and "non-responder" categories, respectively. This practice is often criticized as inappropriate, since co
Externí odkaz:
https://doaj.org/article/44ddcfa23fe54014975230774209d4d7
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0242320 (2020)
Normative modeling is an increasingly popular method for characterizing the ways in which clinical cohorts deviate from a reference population, with respect to one or more biological features. In this paper, we extend the normative modeling framework
Externí odkaz:
https://doaj.org/article/0f8c0b9b76be493986583877f2493cc4
Publikováno v:
Frontiers in Systems Neuroscience, Vol 13 (2019)
The distributed nature of information processing in the brain creates a complex variety of decision making behavior. Likewise, computational models of saccadic decision making behavior are numerous and diverse. Here we present a generative model of s
Externí odkaz:
https://doaj.org/article/c49724609991479b9b47c4c5416b2919
Publikováno v:
Entropy, Vol 22, Iss 8, p 858 (2020)
A system’s heterogeneity (diversity) is the effective size of its event space, and can be quantified using the Rényi family of indices (also known as Hill numbers in ecology or Hannah–Kay indices in economics), which are indexed by an elasticity
Externí odkaz:
https://doaj.org/article/0158c954572f4a89b242e4aca3f1c11b
Publikováno v:
Entropy, Vol 22, Iss 4, p 417 (2020)
A discrete system’s heterogeneity is measured by the Rényi heterogeneity family of indices (also known as Hill numbers or Hannah–Kay indices), whose units are the numbers equivalent. Unfortunately, numbers equivalent heterogeneity measures for n
Externí odkaz:
https://doaj.org/article/688919b288e543498c8484ad5911b090