Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Thomas Thisted"'
Autor:
Thomas Thisted, F. Donelson Smith, Arnab Mukherjee, Yuliya Kleschenko, Feng Feng, Zhi-Gang Jiang, Timothy Eitas, Kanam Malhotra, Zuzana Biesova, Adejumoke Onumajuru, Faith Finley, Anokhi Cifuentes, Guolin Zhang, Gaëlle H. Martin, Yoshiko Takeuchi, Kader Thiam, Robert D. Schreiber, Edward H. van der Horst
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract VISTA, an inhibitory myeloid-T-cell checkpoint, holds promise as a target for cancer immunotherapy. However, its effective targeting has been impeded by issues such as rapid clearance and cytokine release syndrome observed with previous VIST
Externí odkaz:
https://doaj.org/article/5baa81963d6e484cb872b3eac39edd59
Autor:
Gaëlle H. Martin, Alexis Gonon, Perrine Martin-Jeantet, Florence Renart-Depontieu, Zuzana Biesova, Anokhi Cifuentes, Arnab Mukherjee, Thomas Thisted, Astrid Doerner, Dean O. Campbell, Ludovic Bourré, Edward H. van der Horst, Amélie Rezza, Kader Thiam
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
ObjectivesDespite their efficacy, some immunotherapies have been shown to induce immune-related adverse events, including the potentially life-threatening cytokine release syndrome (CRS), calling for reliable and translational preclinical models to p
Externí odkaz:
https://doaj.org/article/f1b517b31b7b45c781d7edf8fa9804ce
Publikováno v:
Antibodies, Vol 12, Iss 3, p 55 (2023)
Immune checkpoints and other immunoregulatory targets can be difficult to precisely target due to expression on non-tumor immune cells critical to maintaining immune homeostasis in healthy tissues. On-target/off-tumor binding of therapeutics results
Externí odkaz:
https://doaj.org/article/0e0955ff91804c98a568f65c79a9c7e1
Autor:
Kanam Malhotra, Thomas Thisted, Arnab Mukherjee, Zuzana Biesova, Yuliya Kleschenko, Zhi-Gang Jiang, Anokhi Cifuentes, Nadthakarn Boland, Nels Nielson, Edward van der Horst
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/a7171874660f48d1bde798669b971c40
Autor:
Thomas Thisted, Zuzana Biesova, Celine Walmacq, Everett Stone, Max Rodnick-Smith, Shaheda S. Ahmed, Stephen K. Horrigan, Bo Van Engelen, Charles Reed, Matthew W. Kalnik
Publikováno v:
BMC Biotechnology, Vol 19, Iss 1, Pp 1-16 (2019)
Abstract Background Smoking and tobacco use continue to be the largest preventable causes of death globally. A novel therapeutic approach has recently been proposed: administration of an enzyme that degrades nicotine, the main addictive component of
Externí odkaz:
https://doaj.org/article/ae7ac2f2d8ba4722aab56dc2aabefcbe
Autor:
Michael D Raleigh, Nicola Beltraminelli, Stephanie Fallot, Mark G LeSage, Amy Saykao, Paul R Pentel, Steve Fuller, Thomas Thisted, Zuzanna Biesova, Stephen Horrigan, Darryl Sampey, Bin Zhou, Matthew W Kalnik
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0254247 (2021)
Use of nicotine-specific monoclonal antibodies (mAbs) to sequester and reduce nicotine distribution to brain has been proposed as a therapeutic approach to treat nicotine addiction (the basis of tobacco use disorder). A series of monoclonal antibodie
Externí odkaz:
https://doaj.org/article/20970bf6715646829279dd4d4d1ec7c3
Autor:
Paul R. Pentel, Michael D. Raleigh, Mark G. LeSage, Thomas Thisted, Stephen Horrigan, Zuzana Biesova, Matthew W. Kalnik
Publikováno v:
BMC Biotechnology, Vol 18, Iss 1, Pp 1-14 (2018)
Abstract Background The bacterial nicotine-degrading enzyme NicA2 isolated from P. putida was studied to assess its potential use in the treatment of tobacco dependence. Results Rats were pretreated with varying i.v. doses of NicA2, followed by i.v.
Externí odkaz:
https://doaj.org/article/a0e3cd1965a54648bfdb8c93d6f253a0
Autor:
Tim Eitas, Edward van der Horst, Faith Finley, Thomas Thisted, Kanam Malhotra, Arnab Mukherjee, Zuzana Biesova, Anokhi Cifuentes, Sandra Marder, Paul Helbling, Robert Pierce
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46f08dea35f663af8ee1496660e8bd41
https://doi.org/10.1136/jitc-2022-sitc2022.0485
https://doi.org/10.1136/jitc-2022-sitc2022.0485
Autor:
Thomas Thisted, Tim Eitas, Kanam Malhotra, Yuliya Kleschenko, Faith Finley, Zhi-Gang Jiang, Arnab Mukherjee, Zuzana Biesova, Anokhi Cifuentes, Robert Pierce, Edward van der Horst
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5de1bcc045eb7e48ce0a025fff895074
https://doi.org/10.1136/jitc-2022-sitc2022.0856
https://doi.org/10.1136/jitc-2022-sitc2022.0856
Autor:
Aiping Bai, Elise Renahan, Kanam Malhotra, Thomas Thisted, F. Donelson Smith, Robert H Pierce, Edward H van der Horst
Publikováno v:
Cancer Research. 83:4645-4645
Background CD39 expression is upregulated in the tumor microenvironment (TME), which is characterized by high levels of extracellular ATP (eATP) and low pH. CD39 catalyzes the rate-limiting degradation step of this immunostimulatory ATP, leading to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd7a34b58f3681343605a6f48eb49954
https://doi.org/10.1158/1538-7445.am2023-4645
https://doi.org/10.1158/1538-7445.am2023-4645