Zobrazeno 1 - 10
of 205
pro vyhledávání: '"Thomas Thüm"'
Autor:
Torsten Witte, Thomas Thum, Diana Ernst, Nadine Zehrfeld, Malin Abelmann, Sabrina Benz, Tabea Seeliger, Thomas Skripuletz, Anselm Arthur Derda, Kristina Sonnenschein, Fiona Engelke, Christian Baer
Publikováno v:
RMD Open, Vol 10, Iss 3 (2024)
Background MicroRNAs (miRNAs) can regulate gene expression, controlling numerous cellular processes. Dysregulation of miRNA function is linked to various diseases, making them attractive diagnostic and therapeutic targets. Examples include hsa-miR-92
Externí odkaz:
https://doaj.org/article/3b0f6a42d79d455e86ca3629e831d18b
Autor:
Anselm A. Derda, Malin Abelmann, Kristina Sonnenschein, Jan-Thorben Sieweke, Udo Bavendiek, Johann Bauersachs, Thomas Thum, Dominik Berliner
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
BackgroundHypertrophic cardiomyopathy (HCM), the most common genetic heart disease, is classified into hypertrophic non-obstructive and hypertrophic obstructive cardiomyopathy (HOCM). Patients with HOCM and coexisting heart failure or arterial hypert
Externí odkaz:
https://doaj.org/article/4f502f73d4774851bac43b9cead8c99b
Autor:
Adrien Leger, Ian Brettell, Jack Monahan, Carl Barton, Nadeshda Wolf, Natalja Kusminski, Cathrin Herder, Narendar Aadepu, Clara Becker, Jakob Gierten, Omar T. Hammouda, Eva Hasel, Colin Lischik, Katharina Lust, Natalia Sokolova, Risa Suzuki, Tinatini Tavhelidse, Thomas Thumberger, Erika Tsingos, Philip Watson, Bettina Welz, Kiyoshi Naruse, Felix Loosli, Joachim Wittbrodt, Ewan Birney, Tomas Fitzgerald
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-24 (2022)
Abstract Background The teleost medaka (Oryzias latipes) is a well-established vertebrate model system, with a long history of genetic research, and multiple high-quality reference genomes available for several inbred strains. Medaka has a high toler
Externí odkaz:
https://doaj.org/article/6baa6b6529624872855129b4dacdee87
Autor:
Tomas Fitzgerald, Ian Brettell, Adrien Leger, Nadeshda Wolf, Natalja Kusminski, Jack Monahan, Carl Barton, Cathrin Herder, Narendar Aadepu, Jakob Gierten, Clara Becker, Omar T. Hammouda, Eva Hasel, Colin Lischik, Katharina Lust, Natalia Sokolova, Risa Suzuki, Erika Tsingos, Tinatini Tavhelidse, Thomas Thumberger, Philip Watson, Bettina Welz, Nadia Khouja, Kiyoshi Naruse, Ewan Birney, Joachim Wittbrodt, Felix Loosli
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-32 (2022)
Abstract Background Unraveling the relationship between genetic variation and phenotypic traits remains a fundamental challenge in biology. Mapping variants underlying complex traits while controlling for confounding environmental factors is often pr
Externí odkaz:
https://doaj.org/article/63ed79c9a26844949500ec619ea7c20a
Autor:
Malgorzata Szaroszyk, Badder Kattih, Abel Martin-Garrido, Felix A. Trogisch, Gesine M. Dittrich, Andrea Grund, Aya Abouissa, Katja Derlin, Martin Meier, Tim Holler, Mortimer Korf-Klingebiel, Katharina Völker, Tania Garfias Macedo, Cristina Pablo Tortola, Michael Boschmann, Nora Huang, Natali Froese, Carolin Zwadlo, Mona Malek Mohammadi, Xiaojing Luo, Michael Wagner, Julio Cordero, Robert Geffers, Sandor Batkai, Thomas Thum, Nadja Bork, Viacheslav O. Nikolaev, Oliver J. Müller, Hugo A. Katus, Ali El-Armouche, Theresia Kraft, Jochen Springer, Gergana Dobreva, Kai C. Wollert, Jens Fielitz, Stephan von Haehling, Michaela Kuhn, Johann Bauersachs, Joerg Heineke
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Cachexia is associated with poor prognosis in heart failure. Here the authors show that mice and patients with cardiac cachexia display reduced skeletal muscle expression and circulating levels of Musclin. Musclin ablation in skeletal muscle worsens,
Externí odkaz:
https://doaj.org/article/95984c1d58cc4de49ae09f7ddb642716
Autor:
Anne Raafs, Job Verdonschot, João Pedro Ferreira, Ping Wang, Timothy Collier, Michiel Henkens, Jens Björkman, Alessandro Boccanelli, Andrew L. Clark, Christian Delles, Javier Diez, Arantxa González, Nicolas Girerd, J. Wouter Jukema, Florence Pinet, Patrick Rossignol, Thomas Thum, Nicolas Vodovar, Rudolf A. deBoer, Vanessa vanEmpel, Jan A. Staessen, Mark Hazebroek, John Cleland, Faiez Zannad, Stephane Heymans
Publikováno v:
ESC Heart Failure, Vol 8, Iss 5, Pp 3512-3520 (2021)
Abstract Aims Heart failure (HF) is common in both men and women, yet disease pathophysiology, presentation, and progression differ between sexes. Studies addressing whether biomarkers predict new onset HF sex‐specifically are scarce. This study th
Externí odkaz:
https://doaj.org/article/a0903e2857b544a9b4e4d1d58030724b
Autor:
Stevan D. Stojanović, Maximilian Fuchs, Chunguang Liang, Kevin Schmidt, Ke Xiao, Annette Just, Angelika Pfanne, Andreas Pich, Gregor Warnecke, Peter Braubach, Christina Petzold, Danny Jonigk, Jörg H. W. Distler, Jan Fiedler, Thomas Thum, Meik Kunz
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract The family of RNA-binding proteins (RBP) functions as a crucial regulator of multiple biological processes and diseases. However, RBP function in the clinical setting of idiopathic pulmonary fibrosis (IPF) is still unknown. We developed a pr
Externí odkaz:
https://doaj.org/article/757334abd2ab4df69064526720aa8b80
Autor:
Valerie Etzrodt, Temitayo O. Idowu, Heiko Schenk, Benjamin Seeliger, Antje Prasse, Kristina Thamm, Thorben Pape, Janina Müller-Deile, Matijs van Meurs, Thomas Thum, Ankita Garg, Robert Geffers, Klaus Stahl, Samir M. Parikh, Hermann Haller, Sascha David
Publikováno v:
Critical Care, Vol 25, Iss 1, Pp 1-12 (2021)
Abstract Background Capillary leakage is a key contributor to the pathological host response to infections. The underlying mechanisms remain incompletely understood, and the role of microRNAs (MIR) has not been investigated in detail. We hypothesized
Externí odkaz:
https://doaj.org/article/bf0f5bfb8b664330bb6e1925e0eaf152
Autor:
Kristina Sonnenschein, Jan Fiedler, David de Gonzalo-Calvo, Ke Xiao, Angelika Pfanne, Annette Just, Carolin Zwadlo, Samira Soltani, Udo Bavendiek, Theresia Kraft, Cristobal Dos Remedios, Serghei Cebotari, Johann Bauersachs, Thomas Thum
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Hypertrophic cardiomyopathy (HCM) is one of the most common hereditary heart diseases and can be classified into an obstructive (HOCM) and non-obstructive (HNCM) form. Major characteristics for HCM are the hypertrophy of cardiomyocytes and d
Externí odkaz:
https://doaj.org/article/512e2ec0033c4485af4d7813594d8685
Autor:
Denis Horgan, Andres Metspalu, Marie-Christine Ouillade, Dimitrios Athanasiou, John Pasi, Oumeya Adjali, Patrick Harrison, Cedric Hermans, Giovanni Codacci-Pisanelli, Jasmina Koeva, Thomas Szucs, Viorica Cursaru, Ivica Belina, Chiara Bernini, Suijie Zhuang, Stephen McMahon, Draga Toncheva, Thomas Thum
Publikováno v:
Biomedicine Hub, Vol 5, Iss 3, Pp 1-23 (2020)
Recent advances in biomedicine are opening the door to new approaches, and treatment and prevention are being transformed by novel medicines based on genetic engineering, innovative cell-based therapies and tissue-engineered products, and combination
Externí odkaz:
https://doaj.org/article/03c4b1c6d73e4f6bbb7d99038dd42ff2