Zobrazeno 1 - 10
of 439
pro vyhledávání: '"Thomas T. MacDonald"'
Autor:
Polychronis Pavlidis, Anastasia Tsakmaki, Eirini Pantazi, Katherine Li, Domenico Cozzetto, Jonathan Digby- Bell, Feifei Yang, Jonathan W. Lo, Elena Alberts, Ana Caroline Costa Sa, Umar Niazi, Joshua Friedman, Anna K. Long, Yuchun Ding, Christopher D. Carey, Christopher Lamb, Mansoor Saqi, Matthew Madgwick, Leila Gul, Agatha Treveil, Tamas Korcsmaros, Thomas T. Macdonald, Graham M. Lord, Gavin Bewick, Nick Powell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Mechanisms of non-response to ustekinumab, a biologic targeting IL-23, are currently unclear. Here, the authors show that the transcriptional program regulated by IL-22, an IL-23 responsive cytokine, is enriched in patients with ulcerative colitis un
Externí odkaz:
https://doaj.org/article/09b1e8f2868c4b6694a41d33bf89af3b
Autor:
Kevin J. Roberts, Marion F. Cubitt, Timothy M. Carlton, Lurdes Rodrigues-Duarte, Luana Maggiore, Ray Chai, Simon Clare, Katherine Harcourt, Thomas T. MacDonald, Keith P. Ray, Anna Vossenkämper, Michael R. West, J. Scott Crowe
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Anti-TNFα and anti-IL-23 antibodies are highly effective therapies for Crohn’s disease or ulcerative colitis in a proportion of patients. V56B2 is a novel bispecific domain antibody in which a llama-derived IL-23p19-specific domain antibo
Externí odkaz:
https://doaj.org/article/1e2fe779b63b4101b684f9f331edf0fd
Autor:
Dijue Sun, Urszula Stopka-Farooqui, Sayka Barry, Ezra Aksoy, Gregory Parsonage, Anna Vossenkämper, Melania Capasso, Xinyu Wan, Sherine Norris, Jennifer L. Marshall, Andrew Clear, John Gribben, Thomas T. MacDonald, Christopher D. Buckley, Márta Korbonits, Oliver Haworth
Publikováno v:
Cell Reports, Vol 27, Iss 5, Pp 1461-1471.e4 (2019)
Summary: B cell lymphoma-6 (BCL6) is highly expressed in germinal center B cells, but how its expression is maintained is still not completely clear. Aryl hydrocarbon receptor interacting protein (AIP) is a co-chaperone of heat shock protein 90. Dele
Externí odkaz:
https://doaj.org/article/0e7c48760a0e4810870ae935225004a8
Publikováno v:
Frontiers in Medicine, Vol 4 (2017)
Crohn’s disease is an idiopathic disorder of the gut thought to be caused by a combination of environmental and genetic factors in susceptible individuals. It is characterized by chronic transmural inflammation of the terminal ileum and colon, with
Externí odkaz:
https://doaj.org/article/515a00ccf62b43ad80427f22d7081a83
Autor:
Massimo C. Fantini, Giovanni Monteleone, Francesco Pallone, Thomas T. Macdonald, Markus F. Neurath, Christoph Becker, Daniele Fina, Massimiliano Sarra, Carmine Stolfi, Maximilian J. Waldner, Angelamaria Rizzo
PDF file - 630K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e4924d9c4ea511f7d0a23c68d4ef20
https://doi.org/10.1158/0008-5472.22390118.v1
https://doi.org/10.1158/0008-5472.22390118.v1
Autor:
Massimo C. Fantini, Giovanni Monteleone, Francesco Pallone, Thomas T. Macdonald, Markus F. Neurath, Christoph Becker, Daniele Fina, Massimiliano Sarra, Carmine Stolfi, Maximilian J. Waldner, Angelamaria Rizzo
Patients with inflammatory bowel disease (IBD) have an increased risk of developing colorectal cancer due to chronic inflammation. In IBD, chronic inflammation relies upon a TGFβ signaling blockade, but its precise mechanistic relationship to coliti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14378551da164e85c9467a0697aea269
https://doi.org/10.1158/0008-5472.c.6502838.v1
https://doi.org/10.1158/0008-5472.c.6502838.v1
Autor:
Gabriel A. Rabinovich, Karina Mariño, Cecilia Isabel Muglia, Renata Curciarello, Gustavo Correa, Paolo Biancheri, Martin Yantorno, Antonio Di Sabatino, Alicia M. Sambuelli, Thomas T. MacDonald, Marta A. Toscano, Luciano Gastón Morosi, Guillermo Horacio Docena, Rodrigo Papa-Gobbi, Andrés Rocca
Publikováno v:
Apoptosis. 26:323-337
Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), is characterized by chronic, relapsing intestinal inflammation. Galectin-1 (Gal-1) is an endogenous lectin with key pro-resolving roles, including inducti
Autor:
Samantha Jones, Antonio Di Sabatino, Thomas T. MacDonald, Renata Curciarello, Toni Sobande, Klaartje Kok, Paolo Giuffrida, Guillermo Horacio Docena
Publikováno v:
Journal of Inflammation Research. 13:233-243
Purpose Proteases play an essential role in the pathophysiology of inflammatory bowel disease (IBD), contributing to the intestinal mucosal lesions through the degradation of the extracellular matrix and alteration of the barrier function. Ulcerative
Autor:
Jenni Cryan, Don T. Fisher, Michael Reilly, Ian Edward David Smith, Anna Vossenkämper, Gillian F. Watt, Ian Churcher, John D. Harling, Allison M. Beal, Thomas T. MacDonald, Alina Mares, Phoebe Dace, Bartholomew J. Votta, Marcus Bantscheff, Jane Denyer, Paul Scott-Stevens, Afjal Hussain Miah, Andrew B. Benowitz, Aditya R. Thawani, Carol A. Capriotti, Mark David Rackham, Nico Zinn, Pamela A. Haile
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Communications Biology
Communications Biology
Proteolysis-Targeting Chimeras (PROTACs) are heterobifunctional small-molecules that can promote the rapid and selective proteasome-mediated degradation of intracellular proteins through the recruitment of E3 ligase complexes to non-native protein su
Publikováno v:
World Journal of Gastrointestinal Pathophysiology
BACKGROUND Perianal fistulae are either primary (idiopathic) or secondary [commonly associated with Crohn’s disease, (CD)]. It is assumed, although not proven, that the pathophysiology differs. AIM To systematically compare the clinical phenotypes,