Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Thomas T Joseph"'
Autor:
Aboubacar Wague, Thomas T Joseph, Kellie A Woll, Weiming Bu, Kiran A Vaidya, Natarajan V Bhanu, Benjamin A Garcia, Crina M Nimigean, Roderic G Eckenhoff, Paul M Riegelhaupt
Publikováno v:
eLife, Vol 9 (2020)
K2P potassium channels are known to be modulated by volatile anesthetic (VA) drugs and play important roles in clinically relevant effects that accompany general anesthesia. Here, we utilize a photoaffinity analog of the VA isoflurane to identify a V
Externí odkaz:
https://doaj.org/article/7e11d5322d4c418d8767b99777b16d8b
Autor:
Thomas T Joseph, Joshua S Mincer
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158795 (2016)
General anesthetics bind reversibly to ion channels, modifying their global conformational distributions, but the underlying atomic mechanisms are not completely known. We examine this issue by way of the model protein Gloeobacter violaceous ligand-g
Externí odkaz:
https://doaj.org/article/e9816e554da74c06ac8f012f7da6c909
Autor:
Thomas T Joseph, Roman Osman
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 9, p e1002693 (2012)
In RNA interference, a guide strand derived from a short dsRNA such as a microRNA (miRNA) is loaded into Argonaute, the central protein in the RNA Induced Silencing Complex (RISC) that silences messenger RNAs on a sequence-specific basis. The positio
Externí odkaz:
https://doaj.org/article/b96fd8e894d4496aa7cec2e578a7b42e
Autor:
Johanna Becker-Baldus, Alexei Yeliseev, Thomas T. Joseph, Snorri Th. Sigurdsson, Lioudmila Zoubak, Kirk Hines, Malliga R. Iyer, Arjen van den Berg, Sam Stepnowski, Jon Zmuda, Klaus Gawrisch, Clemens Glaubitz
Publikováno v:
ACS Omega, Vol 8, Iss 36, Pp 32963-32976 (2023)
Externí odkaz:
https://doaj.org/article/543ddeac6e3345cbaafa6a8240ec5d13
Autor:
John T. Petroff, Noah M. Dietzen, Ezry Santiago-McRae, Brett Deng, Maya S. Washington, Lawrence J. Chen, K. Trent Moreland, Zengqin Deng, Michael Rau, James A. J. Fitzpatrick, Peng Yuan, Thomas T. Joseph, Jérôme Hénin, Grace Brannigan, Wayland W. L. Cheng
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Pentameric ligand-gated ion channels are modulated by anionic phospholipids. Here, by capturing an open-channel conformation of ELIC, the authors demonstrate the structural details of channel activation and a leaflet-specific mechanism for modulation
Externí odkaz:
https://doaj.org/article/d772e49e78fb4be7aa7a408b799d12f0
Autor:
John T. Petroff, Noah M. Deitzen, Ezry Santiago-McRae, Brett Deng, Maya S. Washington, Lawrence J. Chen, K. Trent Moreland, Zengqin Deng, Michael Rau, James A. J. Fitzpatrick, Peng Yuan, Thomas T. Joseph, Jérôme Hénin, Grace Brannigan, Wayland W. L. Cheng
Pentameric ligand-gated ion channels (pLGICs) mediate synaptic transmission and are sensitive to their lipid environment. The mechanism of phospholipid modulation of any pLGIC is not well understood. We demonstrate that the model pLGIC, ELIC (Erwinia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d864e4b461367a9fb673545413db7b5e
https://doi.org/10.1101/2022.06.07.494883
https://doi.org/10.1101/2022.06.07.494883
Autor:
Thomas T, Joseph
Publikováno v:
Methods in cell biology. 169
As molecular dynamics simulation projects require ever-increasing amounts of simulation time, they become more complex to implement and more susceptible to unintended interruptions. This makes the task of the investigator in managing such projects mo
Autor:
Lioudmila Zoubak, Roderic G. Eckenhoff, Weiming Bu, Grace Brannigan, Alexei Yeliseev, Thomas T. Joseph, Renyu Liu, Wenzhen Lin
Publikováno v:
ACS Chemical Neuroscience
Ketamine is an anesthetic, analgesic, and antidepressant whose secondary metabolite (2R,6R)-hydroxynorketamine (HNK) has N-methyl-d-aspartate-receptor-independent antidepressant activity in a rodent model. In humans, naltrexone attenuates its antidep
Autor:
Ezry Santiago-McRae, John T. Petroff, Wayland W. Cheng, Thomas T. Joseph, Jérôme Hénin, Grace Brannigan
Publikováno v:
Biophysical Journal. 122:134a
Autor:
Muh-Ching Yee, Aniwaa Owusu Obeng, Eimear E. Kenny, Omri Gottesman, Stephen B. Ellis, Matthew A. Levin, Stephane Wenric, Erwin P. Bottinger, Thomas T. Joseph, Janina M. Jeff, Gillian M. Belbin
Publikováno v:
The Pharmacogenomics Journal
BackgroundThe emergence of genomic data in biobanks and health systems offers new ways to derive medically important phenotypes, including acute phenotypes that occur during in-patient clinical care. We hypothesized that there is a genetic underpinni