Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Thomas T, Murooka"'
Monitoring mouse papillomavirus-associated cancer development using longitudinal Pap smear screening
Autor:
Hannah M. Atkins, Aysegul Aksakal Uslu, Jingwei J. Li, Debra A. Shearer, Sarah A. Brendle, Chen Han, Michael Kozak, Paul Lopez, Deesha Nayar, Karla K. Balogh, Catherine Abendroth, Jean Copper, Keith C. Cheng, Neil D. Christensen, Yusheng Zhu, Stefanie Avril, Adam D. Burgener, Thomas T. Murooka, Jiafen Hu
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT A substantial percentage of the population remains at risk for cervical cancer due to pre-existing human papillomavirus (HPV) infections, despite prophylactic vaccines. Early diagnosis and treatment are crucial for better disease outcomes. T
Externí odkaz:
https://doaj.org/article/6e22c5056c51441a99de50ea519d0897
Autor:
Paola Guizar, Ana Luiza Abdalla, Anne Monette, Kristin Davis, Ramon Edwin Caballero, Meijuan Niu, Xinyun Liu, Oluwaseun Ajibola, Thomas T. Murooka, Chen Liang, Andrew J. Mouland
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110131- (2024)
Summary: HIV-1 hijacks host proteins involved in membrane trafficking, endocytosis, and autophagy that are critical for virus replication. Molecular details are lacking but are essential to inform on the development of alternative antiviral strategie
Externí odkaz:
https://doaj.org/article/00c18013ef8e4b1b99da5bbe44a51b53
Autor:
Romaniya Zayats, Zhirong Mou, Atta Yazdanpanah, Gaurav Gupta, Paul Lopez, Deesha Nayar, Wan H. Koh, Jude E. Uzonna, Thomas T. Murooka
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Cutaneous Leishmania major infection elicits a rapid T cell response that is insufficient to clear residually infected cells, possibly due to the accumulation of regulatory T cells in healed skin. Here, we used Leishmania-specific TCR transg
Externí odkaz:
https://doaj.org/article/e9169ab2405b4fc58156443a44308eab
Autor:
Alain Pulfer, Diego Ulisse Pizzagalli, Paolo Armando Gagliardi, Lucien Hinderling, Paul Lopez, Romaniya Zayats, Pau Carrillo-Barberà, Paola Antonello, Miguel Palomino-Segura, Benjamin Grädel, Mariaclaudia Nicolai, Alessandro Giusti, Marcus Thelen, Luca Maria Gambardella, Thomas T Murooka, Olivier Pertz, Rolf Krause, Santiago Fernandez Gonzalez
Publikováno v:
eLife, Vol 12 (2024)
Intravital microscopy has revolutionized live-cell imaging by allowing the study of spatial–temporal cell dynamics in living animals. However, the complexity of the data generated by this technology has limited the development of effective computat
Externí odkaz:
https://doaj.org/article/7e7d13c61fdf4ad4b1ddfbc78e28f7a6
Autor:
Nicolas Bellini, Chengyu Ye, Oluwaseun Ajibola, Thomas T. Murooka, Robert Lodge, Éric A. Cohen
Publikováno v:
Viruses, Vol 16, Iss 7, p 1076 (2024)
MicroRNAs (miRNAs) play important roles in the control of HIV-1 infection. Here, we performed RNA-seq profiling of miRNAs and mRNAs expressed in CD4+ T lymphocytes upon HIV-1 infection. Our results reveal significant alterations in miRNA and mRNA exp
Externí odkaz:
https://doaj.org/article/98ea85c54eba4a34b070bb0e76291d42
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Successful antiretroviral therapy (ART) can efficiently suppress Human Immunodeficiency Virus-1 (HIV-1) replication to undetectable levels, but rare populations of infected memory CD4+ T cells continue to persist, complicating viral eradicat
Externí odkaz:
https://doaj.org/article/41290bc463734fe9a53429297a2dfd08
Autor:
Nicolas Bellini, Robert Lodge, Tram N.Q. Pham, Jaspreet Jain, Thomas T. Murooka, Alon Herschhorn, Nicole F. Bernard, Jean-Pierre Routy, Cécile L. Tremblay, Éric A. Cohen
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105234- (2022)
Summary: Activated-to-memory transitioning CD4+ T cells display elevated expression of the HIV-1 co-receptor CCR5 and are more prone to HIV-1 latent infection. Here, we show that p53-regulated miRNA-103 downmodulates CCR5 levels in CD4+ T lymphocytes
Externí odkaz:
https://doaj.org/article/30d4e7980f46475a9a5b3a72a2a0365d
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
The risk of HIV acquisition is low on a per-contact basis but increased by transmission co-factors such as other sexually transmitted infections (STIs). Human papillomavirus (HPV) is a prevalent STI that most individuals will acquire HPV in their lif
Externí odkaz:
https://doaj.org/article/98b7b0be373440d9931bc2515c832d58
Autor:
Tadashi Hosoya, Dunai Cordelia, Benedict D. Michael, Chie Miyabe, Jun Nagai, Thomas T. Murooka, Yoshishige Miyabe
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/b2dc61fcf98c44f4aca7dfa7816648a0
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Intravital microscopy, such as 2-photon microscopy, is now a mainstay in immunological research to visually characterize immune cell dynamics during homeostasis and pathogen infections. This approach has been especially beneficial in describing the c
Externí odkaz:
https://doaj.org/article/65df8d197ed9480fae470a39bf9b8754