Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Thomas T, Joseph"'
Autor:
Johanna Becker-Baldus, Alexei Yeliseev, Thomas T. Joseph, Snorri Th. Sigurdsson, Lioudmila Zoubak, Kirk Hines, Malliga R. Iyer, Arjen van den Berg, Sam Stepnowski, Jon Zmuda, Klaus Gawrisch, Clemens Glaubitz
Publikováno v:
ACS Omega, Vol 8, Iss 36, Pp 32963-32976 (2023)
Externí odkaz:
https://doaj.org/article/543ddeac6e3345cbaafa6a8240ec5d13
Autor:
John T. Petroff, Noah M. Dietzen, Ezry Santiago-McRae, Brett Deng, Maya S. Washington, Lawrence J. Chen, K. Trent Moreland, Zengqin Deng, Michael Rau, James A. J. Fitzpatrick, Peng Yuan, Thomas T. Joseph, Jérôme Hénin, Grace Brannigan, Wayland W. L. Cheng
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Pentameric ligand-gated ion channels are modulated by anionic phospholipids. Here, by capturing an open-channel conformation of ELIC, the authors demonstrate the structural details of channel activation and a leaflet-specific mechanism for modulation
Externí odkaz:
https://doaj.org/article/d772e49e78fb4be7aa7a408b799d12f0
Autor:
Alexei Yeliseev, Malliga R. Iyer, Thomas T. Joseph, Nathan J. Coffey, Resat Cinar, Lioudmila Zoubak, George Kunos, Klaus Gawrisch
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Signaling through integral membrane G protein-coupled receptors (GPCRs) is influenced by lipid composition of cell membranes. By using novel high affinity ligands of human cannabinoid receptor CB2, we demonstrate that cholesterol increases b
Externí odkaz:
https://doaj.org/article/f7405dfa40aa4301afa918bbd3f3c38d
Autor:
Aboubacar Wague, Thomas T Joseph, Kellie A Woll, Weiming Bu, Kiran A Vaidya, Natarajan V Bhanu, Benjamin A Garcia, Crina M Nimigean, Roderic G Eckenhoff, Paul M Riegelhaupt
Publikováno v:
eLife, Vol 9 (2020)
K2P potassium channels are known to be modulated by volatile anesthetic (VA) drugs and play important roles in clinically relevant effects that accompany general anesthesia. Here, we utilize a photoaffinity analog of the VA isoflurane to identify a V
Externí odkaz:
https://doaj.org/article/7e11d5322d4c418d8767b99777b16d8b
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract Repletion of electrolytes often depends on provider-specific behavior and hospital policy. We examined the pattern of electrolyte repletion across several intensive care units (ICU) in a large healthcare system from 2010–2015. This include
Externí odkaz:
https://doaj.org/article/855583b3109e44f1ba26326d720acd12
Autor:
John T. Petroff, Noah M. Deitzen, Ezry Santiago-McRae, Brett Deng, Maya S. Washington, Lawrence J. Chen, K. Trent Moreland, Zengqin Deng, Michael Rau, James A. J. Fitzpatrick, Peng Yuan, Thomas T. Joseph, Jérôme Hénin, Grace Brannigan, Wayland W. L. Cheng
Pentameric ligand-gated ion channels (pLGICs) mediate synaptic transmission and are sensitive to their lipid environment. The mechanism of phospholipid modulation of any pLGIC is not well understood. We demonstrate that the model pLGIC, ELIC (Erwinia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d864e4b461367a9fb673545413db7b5e
https://doi.org/10.1101/2022.06.07.494883
https://doi.org/10.1101/2022.06.07.494883
Autor:
Thomas T, Joseph
Publikováno v:
Methods in cell biology. 169
As molecular dynamics simulation projects require ever-increasing amounts of simulation time, they become more complex to implement and more susceptible to unintended interruptions. This makes the task of the investigator in managing such projects mo
Autor:
Lioudmila Zoubak, Roderic G. Eckenhoff, Weiming Bu, Grace Brannigan, Alexei Yeliseev, Thomas T. Joseph, Renyu Liu, Wenzhen Lin
Publikováno v:
ACS Chemical Neuroscience
Ketamine is an anesthetic, analgesic, and antidepressant whose secondary metabolite (2R,6R)-hydroxynorketamine (HNK) has N-methyl-d-aspartate-receptor-independent antidepressant activity in a rodent model. In humans, naltrexone attenuates its antidep
Autor:
Ezry Santiago-McRae, John T. Petroff, Wayland W. Cheng, Thomas T. Joseph, Jérôme Hénin, Grace Brannigan
Publikováno v:
Biophysical Journal. 122:134a
Autor:
Muh-Ching Yee, Aniwaa Owusu Obeng, Eimear E. Kenny, Omri Gottesman, Stephen B. Ellis, Matthew A. Levin, Stephane Wenric, Erwin P. Bottinger, Thomas T. Joseph, Janina M. Jeff, Gillian M. Belbin
Publikováno v:
The Pharmacogenomics Journal
BackgroundThe emergence of genomic data in biobanks and health systems offers new ways to derive medically important phenotypes, including acute phenotypes that occur during in-patient clinical care. We hypothesized that there is a genetic underpinni