Výsledky vyhledávání - "Thomas Suren"

Active unfolding of the glucocorticoid receptor by the Hsp70/Hsp40 chaperone system in single-molecule mechanical experiments

Autor: Patrick Moessmer, Thomas Suren, Ulrike Majdic, Vinay Dahiya, Daniel Rutz, Johannes Buchner, Matthias Rief

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 119(15)

The glucocorticoid receptor (GR) is an important transcription factor and drug target linked to a variety of biological functions and diseases. It is one of the most stringent physiological clients of the Hsp90/Hsp70/Hsp40 chaperone system. In this s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9885ded6bc380b0b0b4dd092d6702a4e
https://pubmed.ncbi.nlm.nih.gov/35377810

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Single-molecule force spectroscopy reveals folding steps associated with hormone binding and activation of the glucocorticoid receptor

Autor: Daniel A. Rutz, Thomas Suren, Johannes Buchner, Patrick Mößmer, Matthias Rief, Ulrich Merkel

The glucocorticoid receptor (GR) is a prominent nuclear receptor linked to a variety of diseases and an important drug target. Binding of hormone to its ligand binding domain (GR-LBD) is the key activation step to induce signaling. This process is ti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6aafc16bd8dcece25e83953195f3464
https://europepmc.org/articles/PMC6243279/