Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Thomas Strub"'
LKB1‐SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition
Autor:
Sarah Proteau, Imène Krossa, Chrystel Husser, Maxime Guéguinou, Federica Sella, Karine Bille, Marie Irondelle, Mélanie Dalmasso, Thibault Barouillet, Yann Cheli, Céline Pisibon, Nicole Arrighi, Sacha Nahon‐Estève, Arnaud Martel, Lauris Gastaud, Sandra Lassalle, Olivier Mignen, Patrick Brest, Nathalie M Mazure, Frédéric Bost, Stéphanie Baillif, Solange Landreville, Simon Turcotte, Dan Hasson, Saul Carcamo, Christophe Vandier, Emily Bernstein, Laurent Yvan‐Charvet, Mitchell P Levesque, Robert Ballotti, Corine Bertolotto, Thomas Strub
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 12, Pp n/a-n/a (2023)
Abstract Metastatic uveal melanomas are highly resistant to all existing treatments. To address this critical issue, we performed a kinome‐wide CRISPR‐Cas9 knockout screen, which revealed the LKB1‐SIK2 module in restraining uveal melanoma tumor
Externí odkaz:
https://doaj.org/article/1a3e75bad0684eebb8afbad93d505cd9
Autor:
Yann Cheli, Meri K. Tulic, Najla El Hachem, Nicolas Nottet, Arnaud Jacquel, Maeva Gesson, Thomas Strub, Karine Bille, Alexandra Picard-Gauci, Henri Montaudié, Guillaume E. Beranger, Thierry Passeron, Pierre Close, Corine Bertolotto, Robert Ballotti
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-5 (2021)
Abstract Resistances to immunotherapies remains a major hurdle towards a cure for melanoma in numerous patients. An increase in the mesenchymal phenotype and a loss of differentiation have been clearly associated with resistance to targeted therapies
Externí odkaz:
https://doaj.org/article/a109a58f73fa4ac585009c1946fc3fba
Publikováno v:
Cancers, Vol 14, Iss 19, p 4865 (2022)
Epigenetic regulations, that comprise histone modifications and DNA methylation, are essential to processes as diverse as development and cancer. Among the histone post-translational modifications, lysine methylation represents one of the most import
Externí odkaz:
https://doaj.org/article/86fc85a951e14150aa2889911470ecb8
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 11, p 6001 (2022)
Microphthalmia-associated transcription factor (MITF) is an important regulator of melanogenesis and melanocyte development. Although it has been studied extensively in cutaneous melanoma, the role of MITF in uveal melanoma (UM) has not been explored
Externí odkaz:
https://doaj.org/article/a73eebefd2a34d72b39b4bae384a2f80
Autor:
Thomas Strub, Flavia G. Ghiraldini, Saul Carcamo, Man Li, Aleksandra Wroblewska, Rajendra Singh, Matthew S. Goldberg, Dan Hasson, Zichen Wang, Stuart J. Gallagher, Peter Hersey, Avi Ma’ayan, Georgina V. Long, Richard A. Scolyer, Brian Brown, Bin Zheng, Emily Bernstein
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The epigenetic mechanisms of melanoma drug resistance are poorly understood. Here, the authors develop a CRISPR-Cas9 screen targeting epigenetic regulators and discover that SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK
Externí odkaz:
https://doaj.org/article/bec741aeed1b4f7292b8e63eab1bc699
Autor:
Yann Cheli, Meri K. Tulic, Najla El Hachem, Nicolas Nottet, Arnaud Jacquel, Maeva Gesson, Thomas Strub, Karine Bille, Alexandra Picard-Gauci, Henri Montaudié, Guillaume E. Beranger, Thierry Passeron, Pierre Close, Corine Bertolotto, Robert Ballotti
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-1 (2021)
An amendment to this paper has been published and can be accessed via the original article.
Externí odkaz:
https://doaj.org/article/046931caca0a4d15a0880c5b9c1c5cee
Autor:
Dana Koludrovic, Patrick Laurette, Thomas Strub, Céline Keime, Madeleine Le Coz, Sebastien Coassolo, Gabrielle Mengus, Lionel Larue, Irwin Davidson
Publikováno v:
PLoS Genetics, Vol 11, Iss 10, p e1005555 (2015)
MIcrophthalmia-associated Transcription Factor (MITF) regulates melanocyte and melanoma physiology. We show that MITF associates the NURF chromatin-remodelling factor in melanoma cells. ShRNA-mediated silencing of the NURF subunit BPTF revealed its e
Externí odkaz:
https://doaj.org/article/df1f8fa45dc84808a8aeff604c0b8092
Autor:
Patrick Laurette, Thomas Strub, Dana Koludrovic, Céline Keime, Stéphanie Le Gras, Hannah Seberg, Eric Van Otterloo, Hana Imrichova, Robert Siddaway, Stein Aerts, Robert A Cornell, Gabrielle Mengus, Irwin Davidson
Publikováno v:
eLife, Vol 4 (2015)
Microphthalmia-associated transcription factor (MITF) is the master regulator of the melanocyte lineage. To understand how MITF regulates transcription, we used tandem affinity purification and mass spectrometry to define a comprehensive MITF interac
Externí odkaz:
https://doaj.org/article/b685e02106604747b3e01f01e7b91f35
Autor:
Imène Krossa, Thomas Strub, Arnaud Martel, Sacha Nahon-Esteve, Sandra Lassalle, Paul Hofman, Stéphanie Baillif, Robert Ballotti, Corine Bertolotto
Publikováno v:
Theranostics. 12(9)
The NOTCH signaling system regulates a variety of cellular processes during embryonic development and homeostasis maintenance in different tissues and contexts. Hence, dysregulation of NOTCH signaling is associated with a plethora of human cancers, a
Autor:
Corine Bertolotto, Thomas Strub, Henri Montaudié, Pierre Close, Thierry Passeron, Karine Bille, Arnaud Jacquel, Najla El Hachem, Robert Ballotti, Maeva Gesson, Meri K. Tulic, Guillaume E. Beranger, Alexandra Picard-Gauci, Yann Cheli, Nicolas Nottet
Publikováno v:
Molecular Cancer
Molecular Cancer, BioMed Central, 2021, 20 (1), pp.12. ⟨10.1186/s12943-020-01306-2⟩
Molecular Cancer, Vol 20, Iss 1, Pp 1-5 (2021)
Molecular Cancer, BioMed Central, 2021, 20 (1), pp.12. ⟨10.1186/s12943-020-01306-2⟩
Molecular Cancer, Vol 20, Iss 1, Pp 1-5 (2021)
Erratum inCorrection to: ITGBL1 is a new immunomodulator that favors development of melanoma tumors by inhibiting natural killer cells cytotoxicity.Cheli Y, Tulic MK, El Hachem N, Nottet N, Jacquel A, Gesson M, Strub T, Bille K, Picard-Gauci A, Monta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1f2b805f4bdf23db9b9cd5ed6695f1
https://www.hal.inserm.fr/inserm-03138806
https://www.hal.inserm.fr/inserm-03138806