Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Thomas Spitznagel"'
Autor:
Karoline Bechtold-Peters, Jeffrey T. Blue, Hanns-Christian Mahler, Mary E.M. Cromwell, Michel Awwad, Satish K. Singh, Thomas Spitznagel, Doug P. Nesta, Danny K. Chou, Hans-Juergen Krause, Nataliya Afonina, Brian K. Meyer, Linda O. Narhi
Publikováno v:
Journal of Pharmaceutical Sciences. 99:3302-3321
Concern around the lack of monitoring of proteinaceous subvisible particulates in the 0.1-10 microm range has been heightened (Carpenter et al., 2009, J Pharm Sci 98: 1202-1205), primarily due to uncertainty around the potential immunogenicity risk f
Autor:
Samadhi N. Vitharana, LaToya S. Jones, C. Russell Middaugh, Ambarish Shah, Melissa D. Perkins, Adeola O. Grillo, Thomas Spitznagel, Tiffany Derrick, Jason Rexroad
Publikováno v:
Journal of Pharmaceutical Sciences. 96:761-776
The interaction of several of the fibroblast growth factors (FGFs) with polyanions is thought to be of physiological significance and has been exploited to create more stable pharmaceutical formulations of FGF-1 and -2. The extent of such phenomena t
Autor:
Paolo Mangiagalli, Thomas Spitznagel, Michael Rosario Defelippis, Andrew Weiskopf, Bernardo Perez-Ramirez, Hanns-Christian Mahler, Douglas P. Nesta, Atanas Koulov, Patrick Garidel, Robert Simler, Klaus Wuchner, Irene Cecchini, Patricia W. Cash, Vincent Corvari, Linda O. Narhi, Mara Rossi, Roland Schmidt, Shawn Cao, Tony Lubiniecki, Alla Polozova, Andrea Herre, Satish K. Singh, Nataliya Afonina
Publikováno v:
Biologicals : journal of the International Association of Biological Standardization. 43(6)
Measurement and characterization of subvisible particles (including proteinaceous and non-proteinaceous particulate matter) is an important aspect of the pharmaceutical development process for biotherapeutics. Health authorities have increased expect
Publikováno v:
Biophysical Methods for Biotherapeutics: Discovery and Development Applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c710ef37106ffb0cc6ff93c3df6c8f33
https://doi.org/10.1002/9781118354698.ch4
https://doi.org/10.1002/9781118354698.ch4
Autor:
Irene Cecchini, Paolo Mangiagalli, Robert Simler, Hanns-Christian Mahler, Douglas P. Nesta, Patrick Garidel, Dean C. Ripple, Atanas Koulov, Mara Rossi, Bernardo Perez-Ramirez, Satish K. Singh, Thomas Spitznagel, Alla Polozova, Andrew Weiskopf, Nataliya Afonina, Linda O. Narhi, Andrea Herre, Roland Schmidt, Tony Lubiniecki, Vincent Corvari, Michael Rosario Defelippis, Klaus Wuchner
Publikováno v:
Journal of pharmaceutical sciences. 104(6)
Measurement and characterization of subvisible particles (defined here as those ranging in size from 2 to 100 μm), including proteinaceous and nonproteinaceous particles, is an important part of every stage of protein therapeutic development. The to
Publikováno v:
Journal of pharmaceutical sciences. 102(3)
Reversed-phase high-performance liquid chromatography (RP-HPLC), which is routinely used to detect and quantitate levels of protein oxidation, was used to analyze a free cysteine-containing protein. However, the RP-HPLC method appeared to induce dime
Autor:
Angela Blake-Haskins, Yi-Ming Li, Kristin B. Auge, Thomas Spitznagel, Richard P. Affleck, Mark Hesselberg, Eduard Orvisky, Sean Devine, Melissa D. Perkins, Sophia Rizvi
Publikováno v:
Journal of pharmaceutical sciences. 100(12)
Silicone oil is often used to decrease glide forces in prefilled syringes and cartridges, common primary container closures for biopharmaceutical products. Silicone oil has been linked to inducing protein aggregation ( Diabet Med 1989;6:278; Diabet C
Publikováno v:
Current Trends in Monoclonal Antibody Development and Manufacturing ISBN: 9780387766423
Monoclonal antibodies are the most common protein that is being developed by many companies as therapies against a wide range of diseases (Andreakos et al. 2002; Campbell and Marcus 2003; Trikha et al. 2002; Untch et al. 2003). With increasing intere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5009dd7719d31427b767fb80db45784e
https://doi.org/10.1007/978-0-387-76643-0_14
https://doi.org/10.1007/978-0-387-76643-0_14