Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Thomas Spangenberg"'
Autor:
Eva Stadler, Mohamed Maiga, Lukas Friedrich, Vandana Thathy, Claudia Demarta-Gatsi, Antoine Dara, Fanta Sogore, Josefine Striepen, Claude Oeuvray, Abdoulaye A. Djimdé, Marcus C. S. Lee, Laurent Dembélé, David A. Fidock, David S. Khoury, Thomas Spangenberg
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract We report an analysis of the propensity of the antimalarial agent cabamiquine, a Plasmodium-specific eukaryotic elongation factor 2 inhibitor, to select for resistant Plasmodium falciparum parasites. Through in vitro studies of laboratory st
Externí odkaz:
https://doaj.org/article/fc7d61999951431e86b5f6942e16ac55
Autor:
Privat Agniwo, Jérôme Boissier, Bakary Sidibé, Laurent Dembélé, Assitan Diakité, Doumbo Safiatou Niaré, Ahristode Akplogan, Hassim Guindo, Manon Blin, Sarah Dametto, Moudachirou Ibikounlé, Thomas Spangenberg, Abdoulaye Dabo
Publikováno v:
Parasites & Vectors, Vol 16, Iss 1, Pp 1-8 (2023)
Abstract Background Although schistosomiasis is a public health issue in Mali, little is known about the parasite genetic profile. The purpose of this study was to analyze the genetic profile of the schistosomes of Schistosoma haematobium group in sc
Externí odkaz:
https://doaj.org/article/97cae595626b40b3b84051dae5bb081b
Autor:
Privat Agniwo, Jérôme Boissier, Bakary Sidibé, Laurent Dembélé, Assitan Diakité, Doumbo Safiatou Niaré, Ahristode Akplogan, Hassim Guindo, Manon Blin, Sarah Dametto, Moudachirou Ibikounlé, Thomas Spangenberg, Abdoulaye Dabo
Publikováno v:
Parasites & Vectors, Vol 16, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/87f7f932a6b745fcb00ebc570f8cf57d
Autor:
Eva Stadler, Mohamed Maiga, Lukas Friedrich, Vandana Thathy, Claudia Demarta-Gatsi, Antoine Dara, Fanta Sogore, Josefine Striepen, Claude Oeuvray, Abdoulaye A. Djimdé, Marcus C. S. Lee, Laurent Dembélé, David A. Fidock, David S. Khoury, Thomas Spangenberg
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/b0c7124584a34f698dd6a12c343873cc
Autor:
Akash Khandelwal, Francisca Arez, Paula M. Alves, Lassina Badolo, Catarina Brito, Christoph Fischli, Diana Fontinha, Claude Oeuvray, Miguel Prudêncio, Matthias Rottmann, Justin Wilkins, Özkan Yalkinoglu, Wilhelmina M. Bagchus, Thomas Spangenberg
Publikováno v:
Malaria Journal, Vol 21, Iss 1, Pp 1-7 (2022)
Abstract Background Targeting the asymptomatic liver stage of Plasmodium infection through chemoprevention could become a key intervention to reduce malaria-associated incidence and mortality. Methods M5717, a Plasmodium elongation factor 2 inhibitor
Externí odkaz:
https://doaj.org/article/1a184acca8e44dcf9fd53edb5f8e0845
Autor:
Matthew Lacorcia, Réka Kugyelka, Lorenz Spechtenhauser, Ulrich Fabien Prodjinotho, Youssef Hamway, Thomas Spangenberg, Clarissa Prazeres da Costa
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Alongside the wide distribution throughout sub Saharan Africa of schistosomiasis, the morbidity associated with this chronic parasitic disease in endemic regions is often coupled with infection-driven immunomodulatory processes which modify inflammat
Externí odkaz:
https://doaj.org/article/2de276a580474f29be69ba17066a2ec7
Autor:
Justin Komguep Nono, Thabo Mpotje, Paballo Mosala, Nada Abdel Aziz, Fungai Musaigwa, Lerato Hlaka, Thomas Spangenberg, Frank Brombacher
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Beyond transient control of the infection, additional benefits of mass drug administration of praziquantel in endemic communities have been suggested in communities but not mechanistically investigated experimentally. The present study sought to eval
Externí odkaz:
https://doaj.org/article/ee9bab584e164309a33b774665e0974a
Autor:
Thomas B. Duguet, Anastasia Glebov, Asimah Hussain, Shashank Kulkarni, Igor Mochalkin, Timothy G. Geary, Mohammed Rashid, Thomas Spangenberg, Paula Ribeiro
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 13, Iss , Pp 73-88 (2020)
Neglected tropical diseases are of growing worldwide concern and schistosomiasis, caused by parasitic flatworms, continues to be a major threat with more than 200 million people requiring preventive treatment. As praziquantel (PZQ) remains the treatm
Externí odkaz:
https://doaj.org/article/ae57b753674642aabd8528e70e77631a
Autor:
Nermina Vejzagić, Ulrich Fabien Prodjinotho, Nagwa El-Khafif, Ruili Huang, Anton Simeonov, Thomas Spangenberg, Clarissa Prazeres da Costa
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 5, p e0009432 (2021)
BackgroundAnthelminthic treatment options against schistosomiasis are limited. The current treatment relies almost exclusively on a single drug, praziquantel (PZQ). As a consequence, the development of resistance to PZQ and limited activity of PZQ ag
Externí odkaz:
https://doaj.org/article/12d9676546434831be89218d4d3f8d96
Autor:
Nada Abla, Jennifer Keiser, Mireille Vargas, Natalie Reimers, Helmut Haas, Thomas Spangenberg
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 9, p e0005942 (2017)
After more than 40 years of use, Praziquantel (PZQ) still remains the drug of choice for the treatment of intestinal and urogenital schistosomiasis. Its anti-parasitic activity resides primarily in the (R)-enantiomer. Hitherto neither the molecular t
Externí odkaz:
https://doaj.org/article/2773722746664e0cb48de9988ceb99b5