Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Thomas Soucek"'
Publikováno v:
Neuron. 39:43-56
It is frequently argued that both amyloid beta (Abeta) and oxidative stress are involved in the pathogenesis of Alzheimer's disease (AD). We show here that clonal nerve cell lines and primary cortical neurons that are resistant to Abeta toxicity have
Autor:
Katja Braun, Thomas Soucek, Angelina Miloloza, Elke Hengstschläger-Ottnad, Markus Hengstschläger
Publikováno v:
Mutation Research/Reviews in Mutation Research. 436:1-9
In the mammalian cell cycle, the transition from the G1 phase to S phase, in which DNA replication occurs, is dependent on tight cell size control and has been shown to be regulated by the cyclin-dependent kinases (Cdks) 2, 3, 4 and 6. Activities of
Autor:
Markus Hengstschläger, Gabriele Hölzl, Tarik Möröy, Christoph Geisen, Thomas Soucek, Katja Braun
Publikováno v:
Oncogene. 17:2259-2269
The G1-S transition in mammalian cells has been demonstrated to require the cyclin-dependent kinases cdk2, cdk3 and cdk4/6. Here we show that a novel kinase activity associated with cdk3 fluctuates throughout the cell cycle differently from the expre
Publikováno v:
Oncogene. 16:2197-2204
Tuberous sclerosis is an autosomal dominant disorder. Besides the development of benign growths (hamartomas) in different tissues, one hallmark of this disease is the presence of highly epileptogenic dysplastic lesions in the cerebral cortex (tubers)
Publikováno v:
Journal of Biological Chemistry. 272:29301-29308
Tuberous sclerosis is an autosomal dominant disorder characterized by the development of benign growths in many tissues and organs. Linkage analysis revealed two disease-determining genes on chromosome 9 and chromosome 16. The TSC2 gene on chromosome
Autor:
Elke Hengstschläger-Ottnad, Markus Hengstschläger, Gerhard Bernaschek, Thomas Soucek, Oliver Pusch
Publikováno v:
DNA and Cell Biology. 16:737-747
Although a remarkable number of genes has been identified that are either activated or repressed via c-Myc, only few of them obviously contribute to Myc's biological effect--the induction of proliferation. We found that in logarithmically growing cel
Autor:
Thomas Soucek, Markus Hengstschläger, Peter D. Adams, Oliver Pusch, Elke Hengstschläger-Ottnad
Publikováno v:
Oncogene. 14:2251-2257
The transcription factor E2F activates genes required for S phase, such as cyclin E and cyclin A. We show that, contrary to long term effects of E2F-1 overexpression, short ectopic overexpression of this transcription factor in logarithmically growin
Reduced glucose metabolism and astrocyte activation in selective areas of the brain are pathological features of Alzheimer's disease (AD). The underlying mechanisms of low energy metabolism and a molecular basis for preventing astrocyte activation ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415315ae8d31ec92b72a65e7460ba00a
https://europepmc.org/articles/PMC2752839/
https://europepmc.org/articles/PMC2752839/
Autor:
Angelina Miloloza, Margit Rosner, Thomas Soucek, Markus Hengstschläger, Julian R. Sampson, Marion Kubista, Jeremy Peter Cheadle
Publikováno v:
Oncogene. 20(35)
The autosomal dominant disease tuberous sclerosis (TSC) is caused by mutations in either TSC1 on chromosome 9q34, encoding hamartin, or TSC2 on chromosome 16p13.3, encoding tuberin. TSC is characterized by hamartomas that occur in many organs of affe
Tuberous sclerosis is an autosomal dominant disorder characterized by the development of aberrant growths in many tissues and organs. Linkage analysis revealed two disease-determining genes on chromosome 9 and chromosome 16. The tuberous sclerosis co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7807ae1b6faa5b0436887bf0415396d6
https://europepmc.org/articles/PMC28099/
https://europepmc.org/articles/PMC28099/