Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Thomas Solacroup"'
Autor:
Thomas Solacroup, Benjamin Neunstoecklin, Miroslav Soos, Hervé Broly, Massimo Morbidelli, Matthieu Stettler
Publikováno v:
J. Biotechnol.
Application of quality by design (QbD) requires identification of the maximum operating range for parameters affecting the cell culture process. These include hydrodynamic stress, mass transfer or gradients in dissolved oxygen and pH. Since most of t
Autor:
Alex Eon-Duval, Thomas Solacroup, James Sutter, Claire L E Strat, Pascal Valax, Ralf Gleixner, Hervé Broly
Publikováno v:
Journal of Pharmaceutical Sciences. 101:3604-3618
The article describes how Quality by Design principles can be applied to the drug substance manufacturing process of an Fc fusion protein. First, the quality attributes of the product were evaluated for their potential impact on safety and efficacy u
Minimizing hydrodynamic stress in mammalian cell culture through the lobed Taylor-Couette bioreactor
Autor:
Hervé Broly, Robin A. Sorg, Timm Tanzeglock, Massimo Morbidelli, Arnaud Périlleux, Miroslav Soos, Thomas Solacroup
Publikováno v:
Biotechnology Journal. 6:1504-1515
The objective of the present study was to investigate the effect of hydrodynamic stress heterogeneity on metabolism and productivity of an industrial mammalian cell line. For this purpose, a novel Lobed Taylor-Couette (LTC) mixing unit combining a na
Autor:
Hervé Broly, Benjamin Neunstoecklin, Riccardo Leardi, Massimo Morbidelli, Miroslav Soos, Alessandro Butté, Michael Sokolov, Thomas Solacroup, Matthieu Stettler
This work presents a sequential data analysis path, which was successfully applied to identify important patterns (fingerprints) in mammalian cell culture process data regarding process variables, time evolution and process response. The data set inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d248586d35ff9fc62a99ade832d1022
https://hdl.handle.net/11567/865440
https://hdl.handle.net/11567/865440
Autor:
Alex Eon-Duval, Thomas Solacroup, Hervé Broly, Marco Barbafieri, Ralf Gleixner, Yolande Rouiller, Véronique Deparis
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 81(2)
The production bioreactor step of an Fc-Fusion protein manufacturing cell culture process was characterized following Quality by Design principles. Using scientific knowledge derived from the literature and process knowledge gathered during developme