Thrombin generation to evaluate the complex hemostatic balance of hemophilia A plasma containing direct oral anticoagulant and supplemented by factor VIII

Autor: Sylvain Lamoine, Vincent Jury, Virginie Fourneyron, Jonathan Douxfils, Dorian Teissandier, Laurie Talon, Thomas Sinegre, Aurélien Lebreton

Publikováno v: Research and Practice in Thrombosis and Haemostasis, Vol 8, Iss 7, Pp 102576- (2024)

Background: The incidence of cardiovascular diseases is increasing in persons with hemophilia A (HA). Therefore, anticoagulant therapy based on direct oral anticoagulants (DOACs) may be needed, despite the bleeding risk. In case of surgery or bleedin

Externí odkaz: https://doaj.org/article/cd2213ce0bf847a7b9aadd36b2934e9d

Analytical performance of a new immunoturbidimetric D‐dimer assay and comparison with available assays

Autor: Laurie Talon, Virginie Fourneyron, Alexandre Trapani, Bruno Pereira, Thomas Sinegre, Aurélien Lebreton

Publikováno v: Research and Practice in Thrombosis and Haemostasis, Vol 6, Iss 1, Pp n/a-n/a (2022)

Abstract Background The routine D‐dimer quantification to exclude venous thromboembolism has led to the development of many assays, the usefulness of which depends on their reliability and performance. Objective We evaluated the analytical performa

Externí odkaz: https://doaj.org/article/e82e76e578504f0fb58181bad55b7a25

Thrombin Generation and Cirrhosis

Autor: Laurie Talon, Armand Abergel, Ton Lisman, Aurélien Lebreton, Thomas Sinegre, Thomas Lecompte

Publikováno v: Seminars in Thrombosis and Hemostasis
Seminars in Thrombosis and Hemostasis, Thieme Publishing, 2020, 46 (06), pp.693-703. ⟨10.1055/s-0040-1715102⟩
Seminars in thrombosis and hemostasis, 46(6), 693-703. THIEME MEDICAL PUBL INC
Seminars in Thrombosis and Hemostasis, 2020, 46 (06), pp.693-703. ⟨10.1055/s-0040-1715102⟩

Epidemiological and laboratory studies performed in the last decades have changed our understanding of coagulopathy in cirrhosis, from a condition at increased risk of hemorrhagic events to one at higher thrombotic risk. However, it is not clear whet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05059289cc9c8f04402eca04a9fc91d6
https://doi.org/10.1055/s-0040-1715102

[Study of thrombin generation in healthy children]

Autor: Stéphanie Senectaire, Anne-Françoise Sapin, Thomas Sinegre, Alexandre Trapani, Virginie Fourneyron, Aurélien Lebreton, Adeline Trayaud, Laurie Talon, Aurélie Vaissade, Maxence Tillier, Maryse Tardieu

Publikováno v: Annales de biologie clinique. 78(6)

Exploring coagulation in newborns and children is a challenge due to the low levels of both procoagulant factors and inhibitors. Conventional coagulation tests might be inadequate to explore all of these changes. The aim of the study is to evaluate t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05673d816370a4ef8738e19d61d060e8
https://pubmed.ncbi.nlm.nih.gov/33262100

Impact of epicatechin on fibrin clot structure

Autor: Dragan Milenkovic, Thomas Sinegre, Pauline Fully, Christine Morand, Julien Bourdin, Dorian Teissandier, Aurélien Lebreton

Publikováno v: European Journal of Pharmacology
European Journal of Pharmacology, Elsevier, 2021, 893, pp.173830. ⟨10.1016/j.ejphar.2020.173830⟩
European Journal of Pharmacology, 2021, 893, pp.173830. ⟨10.1016/j.ejphar.2020.173830⟩

International audience; Fibrin clot structure and function are major determinants of thromboembolic diseases. The study aim was to determine the impact of epicatechin (a flavonoid with cardiovascular protective effects) on fibrin clot structure and p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691434bfb06a5c8835d779045196b522
https://pubmed.ncbi.nlm.nih.gov/33347819