Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Thomas Sickmann"'
Autor:
Jessica C. Hassel, Lisa Zimmer, Thomas Sickmann, Thomas K. Eigentler, Friedegund Meier, Peter Mohr, Tobias Pukrop, Alexander Roesch, Dirk Vordermark, Christina Wendl, Ralf Gutzmer
Publikováno v:
Cancers, Vol 15, Iss 13, p 3448 (2023)
Available 4- and 5-year updates for progression-free and for overall survival demonstrate a lasting clinical benefit for melanoma patients receiving anti-PD-directed immune checkpoint inhibitor therapy. However, at least one-half of the patients eith
Externí odkaz:
https://doaj.org/article/d4fd23626d304dbfbbe86b15b42bd8dc
Autor:
Friedegund Meier, Dietmar Krex, Dirk Schadendorf, Thomas Sickmann, Dirk Vordermark, Christoph Höller, Thomas Eigentler, Ralf Gutzmer, Christina Wendl, Stefan Rieken, Jessica C. Hassel, Tobias Pukrop
Publikováno v:
Cancer treatment reviews. 89
Melanoma brain metastases (MBM) are common and associated with a particularly poor prognosis; they directly cause death in 60-70% of melanoma patients. In the past, systemic treatments have shown response rates around 5%, whole brain radiation as sta
Autor:
Christian Alzheimer, Thomas Sickmann
Publikováno v:
Journal of Neurophysiology. 90:2494-2503
Whole cell recordings from acutely isolated rat neocortical pyramidal cells were performed to study the kinetics and the mechanisms of short-term desensitization of G-protein-activated, inwardly rectifying K+ (GIRK) currents during prolonged applicat
Autor:
Christian Alzheimer, Thomas Sickmann
Publikováno v:
Brain Research. 929:166-174
We performed whole-cell recordings from acutely isolated pyramidal cell somata of rat neocortex to measure and compare G protein-activated, inwardly rectifying K+ (GIRK) currents induced by adenosine, serotonin and baclofen at different postnatal sta
Publikováno v:
The Journal of Experimental Zoology. 279:9-28
In Polysarcus denticauda, a phaneropterine bushcricket with extremely thick uncovered tympana and an aberrant morphology of the cristae acusticae of the complex tibial organs, the electrophysiology of the auditory-vibratory ventral cord neurons ascen
Publikováno v:
Entomologia Generalis. 21:265-291
The acoustic-vibratory communication plays an important role within the life cycle of Tettigoniidae. It serves for intraspecific contacts between males and females in aggregation patches supporting especially reproduction, but also population dynamic
Publikováno v:
The Journal of Experimental Zoology. 276:315-329
The complex tibial organs of the bushcricket Polysarcus denticauda (Phaneropterinae) have some exceptional morphological features. In the forelegs, these organs have an extremely thick uncovered tympanum and about 50 receptor cells in the crista acus
Publikováno v:
Journal of Experimental Zoology. 267:377-388
The morphology and the physiology of the auditory receptor organs in the forelegs of the tettigoniid species Gampsocleis gratiosa were investigated in detail. According to the tonotopic organization of the receptor cells of the crista acoustica in bu
Publikováno v:
The Journal of Biochemistry. 111:662-669
As a first approach to testing the working hypothesis that glycosphingolipids are functionally involved in the ontogeny of insects, their chemical distribution in larval organs was determined and any stadium-correlated differences documented. Selecte
Publikováno v:
Neuroscience letters. 436(2)
Stabilization of the binding of phosphatidylinositol bisphosphate (PIP(2)) to G protein-coupled inward rectifier K+ (GIRK) channels is essential for their activation, whereas hydrolysis of PIP(2) by phospholipase C (PLC) inhibits channel activity. Ap