Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Thomas Shum"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15806 (2023)
The efficacy of therapeutic T-cells is limited by a lack of positive signals and excess inhibitory signaling in tumor microenvironments. We previously showed that a constitutively active IL7 receptor (C7R) enhanced the persistence, expansion, and ant
Externí odkaz:
https://doaj.org/article/fe4e3734f1ef447ba725f0f21dcb1878
Autor:
A Uribe-Gomez, Abraham A. Salinas-Miranda, MD, PhD, Acara E. Turner, BS, Adriana M. Strutt, PhD, ABPP, Adrienne Joseph, BS, Alex Wright, BS, Alexander C. Martin, BS, Alexis N. Milton, BS, Amelia Khoei, BS, Amritha Kanakamedala, BA, Angie Iyinbor, BA, Anna O’Neal, BS, Asha Morrow, MD, Ashley M. Butler, PhD, Ashley Young, BS, Asim Shah, MD, Asna Matin, MD, Audrey E. Christiansen, PhD, Boubakari Ibrahimou, PhD, Breanna Alonzo, Chase Ossenkop, BS, Carli O’Neal, BS, Chih-Wei Hsu, PhD, Charles Ikeanyionwu, BS, Chinwe Anyanwu, MPH, Charlotte Rivas, BS, Chioma A. Ikedionwu, BS, Chioma Anugwom, BS, Christopher R. Broda, MD, Claire Bocchini, MD, Claire Cummins, MD, Cliona M. Rooney, PhD, Colton L. Keo-Meier, PhD, Connor Johnson, BS, Courtney Miller-Chism, MD, Courtney Titus, MEd, Crystal L. Parker, MPH, Cylaina Bird, BA, Daniel Mauck, MPH, David Persse, MD, FACEP, Deborah A. Austin, PhD, Deepa Dongarwar, MS, Deepa V. Cherla, MD, Dwayne Wolf, MD, Ph.D, Eleanor Bimla Schwartz, MD, MS, Elena Petrova, PhD, Elias Perli, BS, Elisabeth Shell, PhD, PA-C, Elizabeth U. Tran, MD, Elsa Baena, PhD, Elyse Lopez, BS, Estrellita “Lo” Berry, MPA, Evadne Rodriguez, BA, Fabrizia Faustinella, MD, PhD, FACP, Faith D. Ihekweazu, MD, MS, Faiz Jiwani, MD, MS, Gabriella P. Chmaitelli, BS, Galant Chan, MD, Haijun Wang, PhD, MPH, Hamisu M. Salihu, MD, PhD, Hannah L. Combs, PhD, Hayley Rogers, BS, Heather Haq, MD, MHS, Iberia Romina Sosa, MD, PhD, Irene E. Jose, BS, Isabel Griffin, MPH, J. Cao, Jane Montealegre, PhD, Jason L. Salemi, PhD, MPH, Jennifer Chang, PhD, Jennifer M. Stinson, PhD, JL Mills, Joann Schulte, DO, MPH, Joel Thomas, John Prochaska, PhD, John Saunders, MD, MS, Jonathan Go, BBA, Jonathan Lim, MD, Jordan Salley, BS, Josue Estiven Pineda, BS, Jules Tabilona, MD, Julie L. Holihan, MD, MS, Kanika Bowen-Jallow, MD, MMS, Karla Bernardi, MD, Karla Fredricks, MD, MPH, Katherine B. Salciccioli, MD, Keila N. Lopez, MD,MPH, Kenneth Barning, MD, Kevin Dat Vuong, MA, Korede K. Yusuf, MBBS, PhD, Kristopher Myers, MPH, Kyle Wilson, Larry E. Laufman, EdD, Latanya J. Love, MD, Lauren Nolan, BA, Lauren Schoen, Lillian Huang, MD, Lindsey M. King, PhD, MPH, Lisa F. Nunez, BS, Louis Brown, PhD, Luna Hernandez, Lynn Hydod, M. Agustina Rossetti, PhD, Madeleine Allman, MPH, Mahmood Khan, MD, Makenna Marty, MAS, MaKenzie D. Lee, BS, Maria A. Jaramillo, BS, Maria Vigil, BS, Mariaelena Boyle, Marina Masciale, MD, Marisa Hilliard, PhD, Marisela Munoz, Mary E. Dickinson, PhD, Meishon Bell, MS, Michele K. York, PhD, Michelle Loor, MD, Michelle Lopez, MD, MPH, Mike K. Liang, MD, Moez Karim Aziz, MSECE, Moriel Karla, BS, Nancy Osazuma, Natalya Ramirez, BS, Natasha Navejar, BS, Nicolás Cortés-Penfield, MD, Nicole B. Lyons, BS, Norma Perez, MD, DrPH, NR Barshes, Olivia A. Barron, BA, Oscar A. Olavarria, MD, Petra Constable, BA, Phyllis Nwokolo, BS, Precious Omokaro, BS, Premal Patel, MD, Prithvi Vallabh, BS, Puja Shah, BA, Rafeek A. Yusuf, MD, MS, MPH, Rebecca A. Rosero, BA, Rebecca Lunstroth, JD, MA, Renice Obure, MPH, Robert Beach, MD, Robin Goin-Kochel, PhD, Robin Parihar, MD, PhD, Roger Zoorob, MD, MPH, Ronee E. Wilson, PhD, Rosa Michelle Schmidt, MD, MPH, Rowland Pettit, BS, Sade C. Udoetuk, MD, Sadia Tasnim, Sara Khan, BA, Sareema Adnan, BS, Sean Rodriguez, BA, Sharmila Anandasabapathy, MD, Shawna Nesbitt, MD, Sheena Bhushan, MD, Sherene Sharath, SO Rogers, Son Dinh, BSA, Sophia Banu, MD, Stacey Rose, MD, FACP, Stacy Drake, Ph.D, MPH, RN, AFN-BC, D-AB, Stephanie Morain, PhD, MPH, Stephen R. McCauley, PhD, Sue Abdelaziz, BS, Tahir Malik, BS, Tara L. Rasmussen, PhD, Thomas Shum, Tiana Raphel, BA, Tien C. Ko, MD, Toi Harris, MD, Trevor Hadley, BS, Uchechukwu Akoma, BS, Uwem Bridgette Eduok, BSA, Victoria Armendariz, MS, Yasmin C. Cole-Lewis, PhD, MPH, Zaina Al-Mohtaseb, MD, Zenab Yusuf, MD, MPH
Publikováno v:
International Journal of Maternal and Child Health and AIDS, Vol 9, Iss 2s (2020)
Copyright © 2020 Harris. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cit
Externí odkaz:
https://doaj.org/article/67bfadcd915c47518aabd4323cdec3f7
Autor:
Robert L. Kruse, Thomas Shum, Xavier Legras, Mercedes Barzi, Frank P. Pankowicz, Stephen Gottschalk, Karl-Dimiter Bissig
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 7, Iss C, Pp 32-41 (2017)
Current therapies against hepatitis B virus (HBV) do not reliably cure chronic infection, necessitating new therapeutic approaches. The T cell response can clear HBV during acute infection, and the adoptive transfer of antiviral T cells during bone m
Externí odkaz:
https://doaj.org/article/0eda57cb833d4cb99a64fad628fb7cef
Autor:
Bilal Omer, Paul A. Castillo, Haruko Tashiro, Thomas Shum, Mai T. A. Huynh, Mara Cardenas, Miyuki Tanaka, Andrew Lewis, Tim Sauer, Robin Parihar, Natalia Lapteva, Michael Schmueck-Henneresse, Malini Mukherjee, Stephen Gottschalk, Cliona M. Rooney
Publikováno v:
Frontiers in Medicine, Vol 5 (2018)
The efficacy of T cells expressing chimeric antigen receptors (CARs) for solid tumors has been limited by insufficient CAR T cell expansion and persistence. The use of virus-specific T cells (VSTs) as carriers for CARs may overcome this limitation si
Externí odkaz:
https://doaj.org/article/b94065e18d6045f89d2146ca4b8029aa
Publikováno v:
RadioGraphics. 42:1265-1282
The lymphatic system plays an important role in balancing fluid compartments in the body. It is disrupted by various disease processes in the thorax, including injury to the thoracic lymphatic duct after surgery, as well as malignancy and heart failu
Autor:
Cliona M. Rooney, Caroline Arber, Stephen Gottschalk, Thomas Shum, Chris DeRenzo, Lauren Scherer, Stacey Van Pelt, Silvana Perconti, Candise Tat, Cicilyn Xie, Nazila Nouraee, Sandhya Sharma, Mai Huynh, Rachel Daum, Thomas Pfeiffer, Mara G. Cardenas, Bilal Omer
Supplementary Data from A Costimulatory CAR Improves TCR-based Cancer Immunotherapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3edc6898f8103028b7a50f9d01afc82e
https://doi.org/10.1158/2326-6066.22544366
https://doi.org/10.1158/2326-6066.22544366
Autor:
Cliona M. Rooney, Caroline Arber, Stephen Gottschalk, Thomas Shum, Chris DeRenzo, Lauren Scherer, Stacey Van Pelt, Silvana Perconti, Candise Tat, Cicilyn Xie, Nazila Nouraee, Sandhya Sharma, Mai Huynh, Rachel Daum, Thomas Pfeiffer, Mara G. Cardenas, Bilal Omer
T-cell receptors (TCR) recognize intracellular and extracellular cancer antigens, allowing T cells to target many tumor antigens. To sustain proliferation and persistence, T cells require not only signaling through the TCR (signal 1), but also costim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad28c068683a0dfdb3bc04a41f25d0a
https://doi.org/10.1158/2326-6066.c.6550619.v1
https://doi.org/10.1158/2326-6066.c.6550619.v1
Autor:
Cliona M. Rooney, Stephen Gottschalk, Leonid S. Metelitsa, Malcolm K. Brenner, Hao Liu, Paul Castillo, Robin Parihar, Daofeng Liu, Tim Sauer, Zhongzhen Yi, Kathan Parikh, Dimitrios L. Wagner, Robert L. Kruse, Haruko Tashiro, Bilal Omer, Thomas Shum
Supplementary Figure 3: C7R signaling does not change phenotypic composition of GD2-CAR T-cells during culture.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d28de38422f6720e2574e27ce887f86
https://doi.org/10.1158/2159-8290.22532024.v1
https://doi.org/10.1158/2159-8290.22532024.v1
Autor:
Cliona M. Rooney, Stephen Gottschalk, Leonid S. Metelitsa, Malcolm K. Brenner, Hao Liu, Paul Castillo, Robin Parihar, Daofeng Liu, Tim Sauer, Zhongzhen Yi, Kathan Parikh, Dimitrios L. Wagner, Robert L. Kruse, Haruko Tashiro, Bilal Omer, Thomas Shum
Supplementary Figure 6: Efficient retroviral transduction of T-cells with Î"34, C7R, GD2-CAR, and GD2-CAR.C7R constructs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9834a0d5003b2bdaa1de1ab2deeb6bfd
https://doi.org/10.1158/2159-8290.22532015.v1
https://doi.org/10.1158/2159-8290.22532015.v1
Autor:
Cliona M. Rooney, Stephen Gottschalk, Leonid S. Metelitsa, Malcolm K. Brenner, Hao Liu, Paul Castillo, Robin Parihar, Daofeng Liu, Tim Sauer, Zhongzhen Yi, Kathan Parikh, Dimitrios L. Wagner, Robert L. Kruse, Haruko Tashiro, Bilal Omer, Thomas Shum
Supplementary Figure 5: C7R does not significantly increase intracranial EphA2-CAR T-cell expansion against U373 tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c3a285c1f962f2a8f93d771d8d970de
https://doi.org/10.1158/2159-8290.22532018
https://doi.org/10.1158/2159-8290.22532018