Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Thomas Seidel"'
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Dysfunctional Ca2+ signaling affects the myocardial systole and diastole, may trigger arrhythmia and cause transcriptomic and proteomic modifications in heart failure. Thus, synchronous real-time measurement of Ca2+ and force is essential to
Externí odkaz:
https://doaj.org/article/6d50eb6e3e1645eda58e373fd49ac088
Autor:
Veronika Müller, Margot Ernst, Aygul Baykuchkarova, Filip Koniuszewski, Konstantina Bampali, Thomas Seidel, Petra Scholze
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: The plant-based alkaloid muscimol is a potent agonist of inhibitory GABAA-neurotransmitter receptors. GABAA receptors are a heterogeneous family of pentameric complexes, with 5 out of 19 subunits assembling around the central anion pore
Externí odkaz:
https://doaj.org/article/9ad9bcc34438456cab7ff5517ec36bda
Autor:
Joachim Greiner, Teresa Schiatti, Wenzel Kaltenbacher, Marica Dente, Alina Semenjakin, Thomas Kok, Dominik J. Fiegle, Thomas Seidel, Ursula Ravens, Peter Kohl, Rémi Peyronnet, Eva A. Rog-Zielinska
Publikováno v:
Cells, Vol 13, Iss 12, p 1034 (2024)
In the original publication [...]
Externí odkaz:
https://doaj.org/article/956a8232dedf41df971a0bb4a960e6a9
Autor:
Filip Koniuszewski, Florian D. Vogel, Irena Dajić, Thomas Seidel, Markus Kunze, Matthäus Willeit, Margot Ernst
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
IntroductionMedications which target benzodiazepine (BZD) binding sites of GABAA receptors (GABAARs) have been in widespread use since the nineteen-sixties. They carry labels as anxiolytics, hypnotics or antiepileptics. All benzodiazepines and severa
Externí odkaz:
https://doaj.org/article/6d0385d98de141b7bf745d647ac6b6a5
Autor:
Maximilian J. Klumm, Christian Heim, Dominik J. Fiegle, Michael Weyand, Tilmann Volk, Thomas Seidel
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/ef523fd322ef49a8b6e8c37f094b4ac0
Autor:
Ann-Katrin M. Pfeuffer, Linda K. Küpfer, Thirupura S. Shankar, Stavros G. Drakos, Tilmann Volk, Thomas Seidel
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13514 (2023)
In terms of preserving multicellularity and myocardial function in vitro, the cultivation of beating myocardial slices is an emerging technique in basic and translational cardiac research. It can be used, for example, for drug screening or to study p
Externí odkaz:
https://doaj.org/article/a9f22d9264f746608d6974302c2e87e2
Publikováno v:
Journal of Cheminformatics, Vol 13, Iss 1, Pp 1-14 (2021)
Abstract QSAR methods are widely applied in the drug discovery process, both in the hit‐to‐lead and lead optimization phase, as well as in the drug-approval process. Most QSAR algorithms are limited to using molecules as input and disregard pharm
Externí odkaz:
https://doaj.org/article/672fd38461d54ceea62874e4a84ed33d
Autor:
Yankun Lyu, Vipin K. Verma, Younjee Lee, Iosif Taleb, Rachit Badolia, Thirupura S. Shankar, Christos P. Kyriakopoulos, Craig H. Selzman, William Caine, Rami Alharethi, Sutip Navankasattusas, Thomas Seidel, Stavros G. Drakos, Frank B. Sachse
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-11 (2021)
Abstract It is well established that the aging heart progressively remodels towards a senescent phenotype, but alterations of cellular microstructure and their differences to chronic heart failure (HF) associated remodeling remain ill-defined. Here,
Externí odkaz:
https://doaj.org/article/59c6d15fd2db497ab916c8eb213cf9df
Autor:
Filip Koniuszewski, Florian D. Vogel, Konstantina Bampali, Jure Fabjan, Thomas Seidel, Petra Scholze, Philip B. Schmiedhofer, Thierry Langer, Margot Ernst
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Background: Human pentameric ligand-gated ion channels (pLGICs) comprise nicotinic acetylcholine receptors (nAChRs), 5-hydroxytryptamine type 3 receptors (5-HT3Rs), zinc-activated channels (ZAC), γ-aminobutyric acid type A receptors (GABAARs) and gl
Externí odkaz:
https://doaj.org/article/dc54f068c3bd491a9c80831d692e9b36
Autor:
Maximilian J. Klumm, Christian Heim, Dominik J. Fiegle, Michael Weyand, Tilmann Volk, Thomas Seidel
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Organotypic culture of human ventricular myocardium is emerging in basic and translational cardiac research. However, few institutions have access to human ventricular tissue, whereas atrial tissue is more commonly available and important for studyin
Externí odkaz:
https://doaj.org/article/5dcb4706b80444bfb867673fec4b8afb