Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Thomas Seebeck"'
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 3, Iss 6, p e455 (2009)
BACKGROUND: Chromosome 9 of Trypanosoma brucei contains two closely spaced, very similar open reading frames for cyclic nucleotide specific phosphodiesterases TbrPDEB1 and TbrPDEB2. They are separated by 2379 bp, and both code for phosphodiesterases
Externí odkaz:
https://doaj.org/article/b31929ce38b14967883c3e6c3551649e
Publikováno v:
Evolutionary Psychology, Vol 4 (2006)
It is now well established that genes within the major histocompatibility complex (MHC) somehow affect the production of body odors in several vertebrates, including humans. Here we discuss whether variation in the intensity of body odors may be infl
Externí odkaz:
https://doaj.org/article/eaf3b565ac6c413294cdd4fa33a11fa4
Autor:
Hermann Tenor, Albert J. Kooistra, Hengming Ke, Kristina M. Orrling, Thomas Seebeck, David S. Bailey, Chris de Graaf, Chimed Jansen, Rob Leurs, Iwan J. P. de Esch, Huanchen Wang
Publikováno v:
Journal of Medicinal Chemistry, 2013(56), 2087-2096. American Chemical Society
Jansen, C, Wang, H, Kooistra, A J, de Graaf, C, Orrling, K M, Tenor, H, Seebeck, T, de Esch, I J P, Ke, H & Leurs, R 2013, ' Discovery of novel Trypanosoma brucei phosphodiesterase B1 inhibitors by virtual screening against the unliganded TbrPDEB1 crystal structure ', Journal of Medicinal Chemistry, vol. 2013, no. 56, pp. 2087-2096 . https://doi.org/10.1021/jm3017877
Jansen, C, Wang, H, Kooistra, A J, de Graaf, C, Orrling, K M, Tenor, H, Seebeck, T, de Esch, I J P, Ke, H & Leurs, R 2013, ' Discovery of novel Trypanosoma brucei phosphodiesterase B1 inhibitors by virtual screening against the unliganded TbrPDEB1 crystal structure ', Journal of Medicinal Chemistry, vol. 2013, no. 56, pp. 2087-2096 . https://doi.org/10.1021/jm3017877
Trypanosoma brucei cyclic nucleotide phosphodiesterase B1 (TbrPDEB1) and TbrPDEB2 have recently been validated as new therapeutic targets for human African Trypanosomiasis by both genetic and pharmacological means. In this study we report the crystal
Autor:
Geert Jan Sterk, Paul England, Paul Cos, Erika van den Bogaart, Thomas Seebeck, Vreni Balmer, Anitha Shanmugham, Jean-Robert Ioset, Iwan J. P. de Esch, Xuan Lan Vu, Emily R. Adams, Eric Chatelain, Kristina M. Orrling, Chimed Jansen, Rob Leurs, Patrick Bregy, Andrea C. van de Stolpe, David S. Bailey, Johan Veerman, Stèphanie Zorg, Louis Maes
Publikováno v:
Journal of Medicinal Chemistry, 55, 8745-8756. American Chemical Society
Journal of medicinal chemistry
Journal of medicinal chemistry, 55(20), 8745-8756. American Chemical Society
Orrling, K M, Jansen, C J W, Vu, X L, Balmer, V, Bregy, P, Shanmugham, A, England, P, Bailey, D, Cos, P, Maes, L, Adams, E, van den Bogaart, E, Chatelain, E, Ioset, J R, van de Stolpe, A, Zorg, S, Veerman, J, Seebeck, T, Sterk, G J, de Esch, I J P & Leurs, R 2012, ' Catechol pyrazolinones as trypanocidals: fragment-based design, synthesis, and pharmacological evaluation of nanomolar inhibitors of trypanosomal phosphodiesterase b1 ', Journal of Medicinal Chemistry, vol. 55, pp. 8745-8756 . https://doi.org/10.1021/jm301059b
Journal of medicinal chemistry
Journal of medicinal chemistry, 55(20), 8745-8756. American Chemical Society
Orrling, K M, Jansen, C J W, Vu, X L, Balmer, V, Bregy, P, Shanmugham, A, England, P, Bailey, D, Cos, P, Maes, L, Adams, E, van den Bogaart, E, Chatelain, E, Ioset, J R, van de Stolpe, A, Zorg, S, Veerman, J, Seebeck, T, Sterk, G J, de Esch, I J P & Leurs, R 2012, ' Catechol pyrazolinones as trypanocidals: fragment-based design, synthesis, and pharmacological evaluation of nanomolar inhibitors of trypanosomal phosphodiesterase b1 ', Journal of Medicinal Chemistry, vol. 55, pp. 8745-8756 . https://doi.org/10.1021/jm301059b
Trypanosomal phosphodiesterases B1 and B2 (TbrPDEB1 and TbrPDEB2) play an important role in the life cycle of Trypanosoma brucei, the causative parasite of human African trypanosomiasis (HAT), also known as African sleeping sickness. We used homology
Autor:
Rob Leurs, Jean-Robert Ioset, Chimed Jansen, Iwan J. P. de Esch, Hermann Tenor, Thomas Seebeck, Eric Chatelain, Paul Cos, Louis Maes, Johan Veerman, Toine J. M. van den Bergh, Kristina M. Orrling, Geert Jan Sterk, Ewald E. Edink
Publikováno v:
Veerman, J, van den Bergh, T, Orrling, K M, Jansen, C J W, Cos, P, Maes, L, Chatelain, E, Ioset, J R, Edink, E S E, Tenor, H, Seebeck, T, de Esch, I J P, Leurs, R & Sterk, G J 2016, ' Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidals. ', Bioorganic and Medicinal Chemistry, vol. 24, no. 7, pp. 1573-1581 . https://doi.org/10.1016/j.bmc.2016.02.032
Bioorganic and Medicinal Chemistry, 24(7), 1573-1581. Elsevier Limited
Bioorganic and medicinal chemistry
Bioorganic and Medicinal Chemistry, 24(7), 1573-1581. Elsevier Limited
Bioorganic and medicinal chemistry
Trypanosomal phosphodiesterases B1 and B2 (TbrPDEB1 and TbrPDEB2) play an important role in the life cycle of Trypanosoma brucei, the causative parasite of human African trypanosomiasis (HAT), also known as African sleeping sickness. Knock down of bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa0bf6d3658f0e8125a18f31a5ed38a
https://research.vu.nl/en/publications/989bcb49-4d16-4793-9891-2395627fd6db
https://research.vu.nl/en/publications/989bcb49-4d16-4793-9891-2395627fd6db
Autor:
Benjamin P. Lüscher, Erwin Sigel, Lukas S. Kopp, Lucia Kuhn-Nentwig, Christian Trachsel, Thomas Seebeck, Kathrin Streitberger, Wolfgang Nentwig, Johann Schaller, I. M. Fedorova, Xuan Lan Vu, Lev G. Magazanik
Publikováno v:
JOURNAL OF BIOLOGICAL CHEMISTRY
CsTx-1, the main neurotoxic acting peptide in the venom of the spider Cupiennius salei, is composed of 74 amino acid residues, exhibits an inhibitory cysteine knot motif, and is further characterized by its highly cationic charged C terminus. Venom g
Autor:
Hengming Ke, Yiqian Wan, Thomas Seebeck, Stefan Kunz, Howard Robinson, Gong Chen, Sibylla Martinelli, Huanchen Wang
Publikováno v:
Journal of Biological Chemistry. 287:11788-11797
Trypanosoma cruzi phosphodiesterase C (TcrPDEC) is a potential new drug target for the treatment of Chagas disease but has not been well studied. This study reports the enzymatic properties of various kinetoplastid PDECs and the crystal structures of
Publikováno v:
Molecular Microbiology. 78:757-769
Summary The parasitic protozoa Trypanosoma brucei has a complex life cycle. Oxidative phosphorylation is highly active in the procyclic form but absent from bloodstream cells. The mitochondrial genome encodes several gene products that are required f
Autor:
Thomas Seebeck, Edith Luginbuehl, Stefan Kunz, Judith Schranz-Zumkehr, Michael Oberholzer, Damaris Ryter
Publikováno v:
Eukaryotic cell
The precise subcellular localization of the components of the cyclic AMP (cAMP) signaling pathways is a crucial aspect of eukaryotic intracellular signaling. In the human pathogen Trypanosoma brucei , the strict control of cAMP levels by cAMP-specifi
Autor:
Juergen Klar, Hermann Tenor, Thomas Seebeck, Reto Brun, Selina Bopp, Hans-Peter Beck, Laurent Wentzinger
Publikováno v:
International Journal for Parasitology. 38:1625-1637
Cyclic nucleotide-specific phosphodiesterases (PDEs) have come into focus as interesting potential targets for PDE inhibitor-based anti-parasitic drugs. Genomes of the various agents of human malaria, most notably Plasmodium falciparum, all contain f