Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Thomas Scior"'
Publikováno v:
Molecules, Vol 29, Iss 7, p 1628 (2024)
The insecticidal property of ring C-seco limonoids has been discovered empirically and the target protein identified, but, to date, the molecular mechanism of action has not been described at the atomic scale. We elucidate on computational grounds wh
Externí odkaz:
https://doaj.org/article/781d724838024a8e9df4e7e37f58b23f
Publikováno v:
Viruses, Vol 15, Iss 5, p 1056 (2023)
In this study, we describe the input data and processing steps to find antiviral lead compounds by a virtual screen. Two-dimensional and three-dimensional filters were designed based on the X-ray crystallographic structures of viral neuraminidase co-
Externí odkaz:
https://doaj.org/article/d8c649f0192346308a050f3dafd040fd
Publikováno v:
AMB Express, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Periplasmic oligopeptide binding protein (OppA) is part of a multimeric cytoplasmic membrane protein complex, whose function is known as peptide transporters found in Gram-negative bacteria. A chaperone-like activity has been found for the O
Externí odkaz:
https://doaj.org/article/9a5e316b728a471db450628656be479e
Publikováno v:
Heliyon, Vol 7, Iss 8, Pp e07784- (2021)
The popular recreational drug MDMA (3,4-methylenedioxy-methamphetamine) has a documented potential as a psychopharmacological clinical and research tool. This is due to its unique ability to promote reprocessing of traumatic memories, empathetic and
Externí odkaz:
https://doaj.org/article/3743183e359a49779c6e7c4fd98ac26a
Autor:
Ángel A. Islas, Thomas Scior
Publikováno v:
Molecules, Vol 27, Iss 9, p 2977 (2022)
Despite the recent promising results of MDMA (3,4-methylenedioxy-methamphetamine) as a psychotherapeutic agent and its history of misuse, little is known about its molecular mode of action. MDMA enhances monoaminergic neurotransmission in the brain a
Externí odkaz:
https://doaj.org/article/9d415730b8584d379c0a01941751734e
Autor:
Jorge Lozano-Aponte, Thomas Scior, Francisco Noé Mendoza Ambrosio, Minerva González-Melchor, Christian Alexander
Publikováno v:
Innate Immunity, Vol 26 (2020)
Electrostatic interactions between phosphate anions and Toll-like receptor 4 / Myeloid differentiation factor-2 (TLR4/MD-2) protein complexes of human, murine, equine and canine species were computed. Such knowledge can provide mechanistic informatio
Externí odkaz:
https://doaj.org/article/a42867ad239b44c48a3943af61663cd1
Autor:
Ana Candalija, Thomas Scior, Hans-Richard Rackwitz, Jordan E. Ruiz-Castelan, Ygnacio Martinez-Laguna, José Aguilera
Publikováno v:
Molecules, Vol 26, Iss 13, p 3988 (2021)
This article presents experimental evidence and computed molecular models of a potential interaction between receptor domain D5 of TrkB with the carboxyl-terminal domain of tetanus neurotoxin (Hc-TeNT). Computational simulations of a novel small cycl
Externí odkaz:
https://doaj.org/article/5c5c500ec74f4522ad53b120491fe19a
Autor:
Luis Márquez-Domínguez, Julio Reyes-Leyva, Irma Herrera-Camacho, Gerardo Santos-López, Thomas Scior
Publikováno v:
Molecules, Vol 25, Iss 18, p 4248 (2020)
Neuraminidase (NA) of influenza viruses enables the virus to access the cell membrane. It degrades the sialic acid contained in extracellular mucin. Later, it is responsible for releasing newly formed virions from the membrane of infected cells. Both
Externí odkaz:
https://doaj.org/article/517ae32a508a43e9a5ff962fc41654a9
Autor:
Fernando Villa-Diaz, Susana Lopez-Nunez, Jordan E. Ruiz-Castelan, Eduardo Marcos Salinas-Stefanon, Thomas Scior
Publikováno v:
Molecules, Vol 25, Iss 15, p 3551 (2020)
(1) Background: voltage-gated sodium channels (Navs) are integral membrane proteins that allow the sodium ion flux into the excitable cells and initiate the action potential. They comprise an α (Navα) subunit that forms the channel pore and are cou
Externí odkaz:
https://doaj.org/article/77d23492e38d4cb28b9e8f4716378825
Autor:
Thomas Scior, Bertin Paiz-Candia, Ángel A. Islas, Alfredo Sánchez-Solano, Lourdes Millan-Perez Peña, Claudia Mancilla-Simbro, Eduardo M. Salinas-Stefanon
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 13, Iss C, Pp 229-240 (2015)
The molecular structure modeling of the β1 subunit of the skeletal muscle voltage-gated sodium channel (Nav1.4) was carried out in the twilight zone of very low homology. Structural significance can per se be confounded with random sequence similari
Externí odkaz:
https://doaj.org/article/a38b320935844ce4aa271aa50373d70a