Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Thomas Sciascia"'
Publikováno v:
Metabolites, Vol 14, Iss 9, p 471 (2024)
Nalbuphine (NAL) is a mixed κ-agonist/μ-antagonist opioid with extensive first-pass metabolism. A phase 1 open-label study was conducted to characterize the pharmacokinetics (PKs) of NAL and select metabolites following single oral doses of NAL ext
Externí odkaz:
https://doaj.org/article/a2246a2e93ae4384bca4a04e32f3edc8
Publikováno v:
JAAD International, Vol 7, Iss , Pp 156-163 (2022)
Introduction: Treating chronic pruritus is challenging for dermatologists due to the lack of therapeutic options. We review the effects of κ-opioid receptor (KOR) and μ-opioid receptor (MOR) in the modulation of itch, summarize evidence supporting
Externí odkaz:
https://doaj.org/article/8166c8a6231f425ebb765dfab2f6e6a2
Autor:
Brian S. Kim, Saadet Inan, Sonja Ständer, Thomas Sciascia, Jacek C. Szepietowski, Gil Yosipovitch
Publikováno v:
Experimental Dermatology. 31:1900-1907
Modern genetic approaches in animal models have unveiled novel itch-specific neural pathways, emboldening a paradigm in which drugs can be developed to selectively and potently target itch in a variety of chronic pruritic conditions. In recent years,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1029f2c6ba9779695484732644daf3
https://doi.org/10.1111/exd.14669
https://doi.org/10.1111/exd.14669
Autor:
Toby M. Maher, Cristina Avram, Enoch Bortey, Simon P. Hart, Nikhil Hirani, Philip L. Molyneux, Joanna C. Porter, Jaclyn A. Smith, Thomas Sciascia
Publikováno v:
NEJM Evidence.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a97926e5fc2d28b98d7f6767d0de96aa
https://doi.org/10.1056/evidoa2300083
https://doi.org/10.1056/evidoa2300083
Publikováno v:
British Journal of Clinical Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e8e83d6fe637612a165824e17ffc36e
https://doi.org/10.1111/bcp.15663
https://doi.org/10.1111/bcp.15663
Population pharmacokinetic (PK) and pharmacokinetic- pharmacodynamic (PK-PD) models were used to quantify the exposure-response (E-R) relationship between nalbuphine exposure and 2 widely used rating scales for itch: the Numerical Rating Scale for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d65659c821ab60205d63bd855b9d4d69
https://doi.org/10.22541/au.166177100.03899983/v1
https://doi.org/10.22541/au.166177100.03899983/v1
Publikováno v:
Journal of the American Academy of Dermatology. 85:AB72
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c57693b9da530fda303d6ee94ad0f7e
https://doi.org/10.1016/j.jaad.2021.06.313
https://doi.org/10.1016/j.jaad.2021.06.313
Autor:
Jayant Kumar, Thomas Sciascia, Vandana S Mathur, Tr Study Investigators, Paul W Crawford, Howard Hait
Publikováno v:
American Journal of Nephrology. 46:450-458
Background: Pruritus is a distressing hallmark of the uremic condition, affecting approximately 60% of hemodialysis patients. Abnormal endogenous opioid ligand activity at μ and κ-opioid receptors has been postulated as a mechanism in uremic prurit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ed967ed940a156100dbef20de63890
https://doi.org/10.1159/000484573
https://doi.org/10.1159/000484573
Publikováno v:
SKIN The Journal of Cutaneous Medicine. 5:s29
not available.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21a3471bbeb80902215e49579bac58ed
https://doi.org/10.25251/skin.5.supp.29
https://doi.org/10.25251/skin.5.supp.29