Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Thomas Schmehl"'
Publikováno v:
Therapeutic Advances in Respiratory Disease, Vol 5 (2011)
Inhaled treprostinil is a safe and well-tolerated approved pharmaceutical for the treatment of pulmonary arterial hypertension. In a series of open-label studies and in the pivotal trial with 253 patients, this long-acting prostacyclin analogue demon
Externí odkaz:
https://doaj.org/article/7778f90a87c6470abc2918dd742b9fc8
Autor:
Thomas Kissel, Juliane Nguyen, Werner Seeger, Moritz Beck-Broichsitter, Olga Samsonova, Thomas Schmehl
Publikováno v:
European Journal of Pharmaceutical Sciences. 86:34-40
A suitable aerosol droplet size and formulation output rate is essential for the therapy of lung diseases under application of nebulizers. The current study investigated the potential of amine-modified poly(vinyl alcohol)s as excipients for inhalatio
Autor:
Ralph T. Schermuly, Moritz Beck-Broichsitter, Werner Seeger, Thomas Kissel, Djuro Kosanovic, Hossein Ardeschir Ghofrani, Thomas Schmehl, Andreas Hecker, Tobias Gessler, Norbert Weissmann
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine. 12:63-68
Direct vasodilator delivery to the airways enables a selective therapy of pulmonary hypertension (PH). However, short-term effects of the applied medication require multiple daily inhalations. Controlled release formulations (polymeric nanomedicines)
Publikováno v:
Aerosol Science and Technology. 49:iii-viii
Autor:
Tobias Gessler, Werner Seeger, Moritz Beck-Broichsitter, Alexandra C. Dalla-Bona, Thomas Schmehl
Publikováno v:
Drug Development and Industrial Pharmacy. 41:1704-1709
The process of vibrating-mesh nebulization is affected by sample physicochemical properties. Exemplary, electrolyte supplementation of diverse formulations facilitated the delivery of adequate aerosols for deep lung deposition.This study addressed th
Autor:
Thomas Schmehl, Moritz Beck-Broichsitter, Werner Seeger, Nina Oesterheld, Marie-Christine Knuedeler
Publikováno v:
International Journal of Pharmaceutics. 459:23-29
Pulmonary application of drug-loaded polymeric nanosuspensions is achieved by vibrating-mesh nebulizers, which allow for an output of intact nanocarriers from the nebulizer reservoir. However, adequate aerosol droplet sizes are a prerequisite for an
Autor:
Nina Oesterheld, Thomas Schmehl, Marie-Christine Knuedeler, Moritz Beck-Broichsitter, Werner Seeger
Publikováno v:
International Journal of Pharmaceutics. 461:34-37
Aerosolization of aqueous formulations is of special interest for inhalative drug delivery, where an adequate nebulizer performance represents a prerequisite for improving pulmonary therapy. The present study investigated the interplay of output rate
Autor:
Regina Reul, Moritz Beck-Broichsitter, Thomas Schmehl, Werner Seeger, Tobias Gessler, Monika Rieger
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 84:106-114
Liposomes have attracted extensive attention as inhalative drug delivery vehicles. The preparation of tailored liposomal formulations (i.e. nebulization stability and controlled drug release profiles) would facilitate new perspectives for the treatme
Autor:
Christoph Schweiger, Susanne Roesler, Werner Seeger, Alexander C. Langheinrich, Julia Gauss, Marian Kampschulte, Moritz Beck-Broichsitter, Thomas Schmehl
Publikováno v:
International Journal of Pharmaceutics. 439:230-233
Nanomedicine comprises a significant potential to approach the therapy of severe diseases. Knowledge of nanoparticle behavior at the target site would contribute to the development of specialized tools for respiratory medicine. Here, we were interest
Autor:
Werner Seeger, Thomas Betz, Thomas Schmehl, Udo Bakowsky, Pia Kleimann, Thomas Kissel, Moritz Beck-Broichsitter
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 82:272-280
Strategies for further advancements in pulmonary drug delivery include the application of colloidal carriers. Freeze-drying in the presence of lyoprotectants is a valuable approach to improve long-term stability of biodegradable nanoparticles, but po