Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Thomas Schirrmann"'
Autor:
Sebastian Lutz, Katja Klausz, Anca-Maria Albici, Lea Ebinger, Lea Sellmer, Hannah Teipel, André Frenzel, Anna Langner, Dorothee Winterberg, Steffen Krohn, Michael Hust, Thomas Schirrmann, Stefan Dübel, Regina Scherließ, Andreas Humpe, Martin Gramatzki, Christian Kellner, Matthias Peipp
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The activating receptor natural killer group 2, member D (NKG2D) represents an attractive target for immunotherapy as it exerts a crucial role in cancer immunosurveillance by regulating the activity of cytotoxic lymphocytes. In this study, a panel of
Externí odkaz:
https://doaj.org/article/7c5953b3bdb248e2bc422fe95902d787
Autor:
Leila Abassi, Federico Bertoglio, Željka Mačak Šafranko, Thomas Schirrmann, Marina Greweling-Pils, Oliver Seifert, Fawad Khan, Maeva Katzmarzyk, Henning Jacobsen, Natascha Gödecke, Philip Alexander Heine, André Frenzel, Helena Nowack, Stefan Dübel, Ivan-Christian Kurolt, Roland E. Kontermann, Alemka Markotić, Maren Schubert, Michael Hust, Luka Čičin-Šain
Publikováno v:
Viruses, Vol 15, Iss 11, p 2153 (2023)
As of now, the COVID-19 pandemic has spread to over 770 million confirmed cases and caused approximately 7 million deaths. While several vaccines and monoclonal antibodies (mAb) have been developed and deployed, natural selection against immune recog
Externí odkaz:
https://doaj.org/article/077b33dc2676465b9909db3b22cbe422
Autor:
Kristian Daniel Ralph Roth, Esther Veronika Wenzel, Maximilian Ruschig, Stephan Steinke, Nora Langreder, Philip Alexander Heine, Kai-Thomas Schneider, Rico Ballmann, Viola Fühner, Philipp Kuhn, Thomas Schirrmann, André Frenzel, Stefan Dübel, Maren Schubert, Gustavo Marçal Schmidt Garcia Moreira, Federico Bertoglio, Giulio Russo, Michael Hust
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Antibodies are essential molecules for diagnosis and treatment of diseases caused by pathogens and their toxins. Antibodies were integrated in our medical repertoire against infectious diseases more than hundred years ago by using animal sera to trea
Externí odkaz:
https://doaj.org/article/a209cfb24a6a400db098fc0eff68beaa
Autor:
Federico Bertoglio, Viola Fühner, Maximilian Ruschig, Philip Alexander Heine, Leila Abassi, Thomas Klünemann, Ulfert Rand, Doris Meier, Nora Langreder, Stephan Steinke, Rico Ballmann, Kai-Thomas Schneider, Kristian Daniel Ralph Roth, Philipp Kuhn, Peggy Riese, Dorina Schäckermann, Janin Korn, Allan Koch, M. Zeeshan Chaudhry, Kathrin Eschke, Yeonsu Kim, Susanne Zock-Emmenthal, Marlies Becker, Margitta Scholz, Gustavo Marçal Schmidt Garcia Moreira, Esther Veronika Wenzel, Giulio Russo, Hendrikus S.P. Garritsen, Sebastian Casu, Andreas Gerstner, Günter Roth, Julia Adler, Jakob Trimpert, Andreas Hermann, Thomas Schirrmann, Stefan Dübel, André Frenzel, Joop Van den Heuvel, Luka Čičin-Šain, Maren Schubert, Michael Hust
Publikováno v:
Cell Reports, Vol 36, Iss 4, Pp 109433- (2021)
Summary: The novel betacoronavirus severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) causes a form of severe pneumonia disease called coronavirus disease 2019 (COVID-19). To develop human neutralizing anti-SARS-CoV-2 antibodies, antibody g
Externí odkaz:
https://doaj.org/article/9c2876f60a3849cc9e53afa0c2d3362e
Autor:
Ulrike S. Diesterbeck, Henrike P. Ahsendorf, André Frenzel, Ahmad Reza Sharifi, Thomas Schirrmann, Claus-Peter Czerny
Publikováno v:
Vaccines, Vol 9, Iss 11, p 1308 (2021)
A panel of potent neutralizing antibodies are protective against orthopoxvirus (OPXV) infections. For the development of OPXV-specific recombinant human single-chain antibodies (scFvs), the IgG repertoire of four vaccinated donors was amplified from
Externí odkaz:
https://doaj.org/article/46ac0221921e4932ad936734ce702782
Publikováno v:
Antibodies, Vol 1, Iss 1, Pp 19-38 (2012)
Bivalent single chain (sc)Fv-Fc antibodies have been used for years as recombinant alternatives of natural immunoglobulins. We have extended this approach to the scFv-Fc-scFv antibody format to obtain tetravalent antigen binding and the possibility t
Externí odkaz:
https://doaj.org/article/652a25afc2df4bbfa32d210b27d4fc0d
Publikováno v:
Molecules, Vol 16, Iss 1, Pp 412-426 (2011)
Twenty years after its development, antibody phage display using filamentous bacteriophage represents the most successful in vitro antibody selection technology. Initially, its development was encouraged by the unique possibility of directly generati
Externí odkaz:
https://doaj.org/article/29fad46292a8466eafd85b2381ff5c82
Autor:
Michael Hust, Maren Meysing, Thomas Schirrmann, Martin Selke, Jochen Meens, Gerald-F. Gerlach, Stefan Dübel
Publikováno v:
BioTechniques, Vol 41, Iss 3, Pp 335-342 (2006)
The enrichment of open reading frames (ORFs) from large gene libraries and the presentation of the corresponding polypeptides on filamentous phage M13 (phage display) is frequently used to identify binding partners of unknown ORFs. In particular, pha
Externí odkaz:
https://doaj.org/article/7ece0a025cad4664a8a275c079fb2c16
Autor:
Congcong Zhang, Saskia Helmsing, Marta Zagrebelsky, Thomas Schirrmann, Andrea L J Marschall, Manuela Schüngel, Martin Korte, Michael Hust, Stefan Dübel
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30684 (2012)
BackgroundAlthough p75 neurotrophin receptor (p75NTR) is the first neurotrophin receptor isolated, its diverse physiological functions and signaling have remained elusive for many years. Loss-of-function phenotypic analyses for p75NTR were mainly foc
Externí odkaz:
https://doaj.org/article/bbdf33d0bd4b4812a00661f348dc3479
Autor:
Torsten Rülker, Luzie Voß, Philippe Thullier, Lyn M O' Brien, Thibaut Pelat, Stuart D Perkins, Claudia Langermann, Thomas Schirrmann, Stefan Dübel, Hans-Jürgen Marschall, Michael Hust, Birgit Hülseweh
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37242 (2012)
Venezuelan equine encephalitis virus (VEEV) belongs to the Alphavirus genus and several species of this family are pathogenic to humans. The viruses are classified as potential agents of biological warfare and terrorism and sensitive detection as wel
Externí odkaz:
https://doaj.org/article/4d832b7f19f94e06946b856248f9d5d8