Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Thomas Schaser"'
Autor:
Isabella Elias Yonezawa Ogusuku, Vera Herbel, Simon Lennartz, Caroline Brandes, Eva Argiro, Caroline Fabian, Carola Hauck, Conny Hoogstraten, Sabrina Veld, Lois Hageman, Karin Teppert, Georgia Koutsoumpli, Marieke Griffioen, Nadine Mockel-Tenbrinck, Thomas Schaser, Rosa de Groot, Ian C.D. Johnston, Dominik Lock
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101224- (2024)
Acute myeloid leukemia (AML) is a heterogeneous malignancy that requires further therapeutic improvement, especially for the elderly and for subgroups with poor prognosis. A recently discovered T cell receptor (TCR) targeting mutant nucleophosmin 1 (
Externí odkaz:
https://doaj.org/article/722f01dd698746e597d61bf1c55d549c
Autor:
Karin Teppert, Nora Winter, Vera Herbel, Caroline Brandes, Simon Lennartz, Fabian Engert, Andrew Kaiser, Thomas Schaser, Dominik Lock
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The prognosis for patients with metastatic melanoma is poor and treatment options are limited. Genetically-engineered T cell therapy targeting chondroitin sulfate proteoglycan 4 (CSPG4), however, represents a promising treatment option, especially as
Externí odkaz:
https://doaj.org/article/394eaac8408d4e1c9bc93be49e292a4a
Autor:
Laura Kapitza, Naphang Ho, Thomas Kerzel, Annika M. Frank, Frederic B. Thalheimer, Arezoo Jamali, Thomas Schaser, Christian J. Buchholz, Jessica Hartmann
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Chimeric antigen receptor (CAR)-expressing T cells are a complex and heterogeneous gene therapy product with variable phenotype compositions. A higher proportion of less differentiated CAR T cells is usually associated with improved antitumoral funct
Externí odkaz:
https://doaj.org/article/d16778f7ed9243059db65c4e58de6741
Autor:
Niels Werchau, Bettina Kotter, Elvira Criado-Moronati, Andre Gosselink, Nicole Cordes, Dominik Lock, Simon Lennartz, Carolin Kolbe, Nora Winter, Karin Teppert, Fabian Engert, Brian Webster, Joerg Mittelstaet, Daniel Schaefer, Peter Mallmann, Michael R. Mallmann, Dominik Ratiu, Mario Assenmacher, Thomas Schaser, Michael von Bergwelt-Baildon, Pierre Abramowski, Andrew D. Kaiser
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Solid tumors consist of malignant and nonmalignant cells that together create the local tumor microenvironment (TME). Additionally, the TME is characterized by the expression of numerous soluble factors such as TGF-β. TGF-β plays an important role
Externí odkaz:
https://doaj.org/article/c33c72814d7043f49b55860008ccb5cf
Autor:
Mario Assenmacher, Andrew Kaiser, Michael Hudecek, Razieh Monjezi, Matthias Eyrich, Dominik Lock, Caroline Brandes, Stephan Bates, Simon Lennartz, Karin Teppert, Leon Gehrke, Rafailla Karasakalidou-Seidt, Teodora Lukic, Marco Schmeer, Martin Schleef, Niels Werchau, Sabrina Prommersberger, Thomas Schaser
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background There is an increasing demand for chimeric antigen receptor (CAR) T cell products from patients and care givers. Here, we established an automated manufacturing process for CAR T cells on the CliniMACS Prodigy platform that is scaled to pr
Externí odkaz:
https://doaj.org/article/a0271935abc24905bcbae8721e14d36f
Autor:
Nicole Cordes, Carolin Kolbe, Dominik Lock, Tatjana Holzer, Deborah Althoff, Daniel Schäfer, Franziska Blaeschke, Bettina Kotter, Sandra Karitzky, Claudia Rossig, Toni Cathomen, Tobias Feuchtinger, Iris Bürger, Mario Assenmacher, Thomas Schaser, Andrew D. Kaiser
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 42-53 (2021)
Recently, a rare type of relapse was reported upon treating a B cell acute lymphoblastic leukemia (B-ALL) patient with anti-CD19 chimeric antigen receptor (CAR)-T cells caused by unintentional transduction of residual malignant B cells (CAR-B cells).
Externí odkaz:
https://doaj.org/article/c35a2ae8e0aa4f12be416e571f892b51
Autor:
Jamal Alzubi, Dominik Lock, Manuel Rhiel, Sabrina Schmitz, Stefan Wild, Claudio Mussolino, Markus Hildenbeutel, Caroline Brandes, Julia Rositzka, Simon Lennartz, Simone A. Haas, Kay O. Chmielewski, Thomas Schaser, Andrew Kaiser, Toni Cathomen, Tatjana I. Cornu
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 379-388 (2021)
The potential of adoptive cell therapy can be extended when combined with genome editing. However, variation in the quality of the starting material and the different manufacturing steps are associated with production failure and product contaminatio
Externí odkaz:
https://doaj.org/article/e8aa757ae0ec4109904f3108d8338f68
Autor:
Nicole Cordes, Nora Winter, Carolin Kolbe, Bettina Kotter, Joerg Mittelstaet, Mario Assenmacher, Toni Cathomen, Andrew Kaiser, Thomas Schaser
Publikováno v:
Viruses, Vol 14, Iss 10, p 2157 (2022)
Selective gene delivery to a cell type of interest utilizing targeted lentiviral vectors (LVs) is an efficient and safe strategy for cell and gene therapy applications, including chimeric antigen receptor (CAR)-T cell therapy. LVs pseudotyped with me
Externí odkaz:
https://doaj.org/article/eee4d9380673423ba066e75f1c54c09c
Autor:
Arezoo Jamali, Laura Kapitza, Thomas Schaser, Ian C.D. Johnston, Christian J. Buchholz, Jessica Hartmann
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 371-379 (2019)
Chimeric antigen receptor (CAR)-modified T cells have revealed promising results in the treatment of cancer, but they still need to overcome various hurdles, including a complicated manufacturing process. Receptor-targeted lentiviral vectors (LVs) de
Externí odkaz:
https://doaj.org/article/c37b68b4ab0c43f4b98334f4f052c630
Autor:
Christian J. Buchholz, Klaus Cichutek, Ulrich M. Lauer, Michael Bitzer, Roberto Cattaneo, Kay-Martin O. Hanschmann, Sorin Armeanu, Martina Zimmermann, Thomas Schaser, Michael D. Mühlebach
Supplementary Figure 6 from Liver Cancer Protease Activity Profiles Support Therapeutic Options with Matrix Metalloproteinase–Activatable Oncolytic Measles Virus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1743c628395baf6a88c029c615a947
https://doi.org/10.1158/0008-5472.22384517
https://doi.org/10.1158/0008-5472.22384517