Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Thomas Sandmann"'
Autor:
Dan Xia, Steve Lianoglou, Thomas Sandmann, Meredith Calvert, Jung H. Suh, Elliot Thomsen, Jason Dugas, Michelle E. Pizzo, Sarah L. DeVos, Timothy K. Earr, Chia-Ching Lin, Sonnet Davis, Connie Ha, Amy Wing-Sze Leung, Hoang Nguyen, Roni Chau, Ernie Yulyaningsih, Isabel Lopez, Hilda Solanoy, Shababa T. Masoud, Chun-chi Liang, Karin Lin, Giuseppe Astarita, Nathalie Khoury, Joy Yu Zuchero, Robert G. Thorne, Kevin Shen, Stephanie Miller, Jorge J. Palop, Dylan Garceau, Michael Sasner, Jennifer D. Whitesell, Julie A. Harris, Selina Hummel, Johannes Gnörich, Karin Wind, Lea Kunze, Artem Zatcepin, Matthias Brendel, Michael Willem, Christian Haass, Daniel Barnett, Till S. Zimmer, Anna G. Orr, Kimberly Scearce-Levie, Joseph W. Lewcock, Gilbert Di Paolo, Pascal E. Sanchez
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-29 (2022)
Abstract Background Genetic mutations underlying familial Alzheimer’s disease (AD) were identified decades ago, but the field is still in search of transformative therapies for patients. While mouse models based on overexpression of mutated transge
Externí odkaz:
https://doaj.org/article/9eb417ef38964cb082e476c72c827f5f
Autor:
Anneleen Daemen, Akshata R. Udyavar, Thomas Sandmann, Congfen Li, Linda J. W. Bosch, William O’Gorman, Yijin Li, Amelia Au-Yeung, Chikara Takahashi, Omar Kabbarah, Richard Bourgon, Priti Hegde, Carlos Bais, Meghna Das Thakur
Publikováno v:
PLoS ONE, Vol 16, Iss 12 (2021)
Background Colorectal cancer (CRC) is a leading cause of cancer-related deaths, with a 5% 5-year survival rate for metastatic disease, yet with limited therapeutic advancements due to insufficient understanding of and inability to accurately capture
Externí odkaz:
https://doaj.org/article/ceb3d9ff0113422f8fd18c42ca9291dd
Autor:
Jaakko Mattila, Essi Havula, Erja Suominen, Mari Teesalu, Ida Surakka, Riikka Hynynen, Helena Kilpinen, Juho Väänänen, Iiris Hovatta, Reijo Käkelä, Samuli Ripatti, Thomas Sandmann, Ville Hietakangas
Publikováno v:
Cell Reports, Vol 13, Iss 2, Pp 350-364 (2015)
The ChREBP/Mondo-Mlx transcription factors are activated by sugars and are essential for sugar tolerance. They promote the conversion of sugars to lipids, but beyond this, their physiological roles are insufficiently understood. Here, we demonstrate
Externí odkaz:
https://doaj.org/article/bc787bf3a50e4994b72aac3c86df2c22
Autor:
Bernd Fischer, Thomas Sandmann, Thomas Horn, Maximilian Billmann, Varun Chaudhary, Wolfgang Huber, Michael Boutros
Publikováno v:
eLife, Vol 4 (2015)
Gene–gene interactions shape complex phenotypes and modify the effects of mutations during development and disease. The effects of statistical gene–gene interactions on phenotypes have been used to assign genes to functional modules. However, dir
Externí odkaz:
https://doaj.org/article/041f5fa32d464532bec0192fb7eb5ee0
Autor:
Essi Havula, Mari Teesalu, Tuulia Hyötyläinen, Heini Seppälä, Kiran Hasygar, Petri Auvinen, Matej Orešič, Thomas Sandmann, Ville Hietakangas
Publikováno v:
PLoS Genetics, Vol 9, Iss 4, p e1003438 (2013)
Sugars are important nutrients for many animals, but are also proposed to contribute to overnutrition-derived metabolic diseases in humans. Understanding the genetic factors governing dietary sugar tolerance therefore has profound biological and medi
Externí odkaz:
https://doaj.org/article/2a850470135541abac6e9d08629619d4
Autor:
Paulo M F Cunha, Thomas Sandmann, E Hilary Gustafson, Lucia Ciglar, Michael P Eichenlaub, Eileen E M Furlong
Publikováno v:
PLoS Genetics, Vol 6, Iss 7, p e1001014 (2010)
Understanding how complex patterns of temporal and spatial expression are regulated is central to deciphering genetic programs that drive development. Gene expression is initiated through the action of transcription factors and their cofactors conver
Externí odkaz:
https://doaj.org/article/00363e2f2f57489aa48f0082a5b26fc8
Autor:
Thomas Sandmann, Stephen M Cohen
Publikováno v:
PLoS ONE, Vol 2, Iss 11, p e1265 (2007)
MicroRNAs (miRNAs) are small non-coding RNAs with important regulatory roles in post-transcriptional regulation of metazoan development, homeostasis and disease. The full set of miRNAs is not known for any species and it is believed that many await d
Externí odkaz:
https://doaj.org/article/7d70b469f4b6429d831835462e87f2ca
Autor:
Scarlett J Barker, Mai B Thayer, Chaeyoung Kim, David Tatarakis, Matthew Simon, Rebekah L Dial, Lizanne Nilewski, Robert C Wells, Yinhan Zhou, Megan Afetian, Alfred Chappell, Kylie S Chew, Johann Chow, Allisa Clemens, Claire B Discenza, Jason Dugas, Chrissa Dwyer, Timothy Earr, Connie Ha, David Huynh, Srini Jayaraman, Wanda Kwan, Cathal Mahon, Michelle Pizzo, Elysia Roche, Laura Sanders, Alexander Stergioulis, Raymond Tong, Hai Tran, Joy Zuchero, Anthony A Estrada, Kapil Gadkar, Christopher MM Koth, Pascal E Sanchez, Robert G Thorne, Ryan J Watts, Thomas Sandmann, Lesley Kane, Frank Rigo, Mark S Dennis, Joseph W Lewcock, Sarah L DeVos
Antisense oligonucleotides (ASO) are promising therapies for neurological disorders, though they are unable to cross the blood-brain barrier (BBB) and must be delivered directly to the central nervous system (CNS). Here, we use a human transferrin re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56046f97df89d6a2d15a721b2fca4f31
https://doi.org/10.1101/2023.04.25.538145
https://doi.org/10.1101/2023.04.25.538145
Autor:
Benjamin J. Andreone, Ju Shi, Bettina Van Lengerich, Thomas Sandmann, Sonnet S. Davis, Anil Rana, Yuan Mei, Giuseppe Astarita, Joseph W. Lewcock, Karin Lin, Ceyda Llapashtica, Kathryn M. Monroe, Gilbert Di Paolo, Laralynne Przybyla
Publikováno v:
Nature Neuroscience. 23:927-938
Human genetic data indicate that microglial dysfunction contributes to the pathology of Alzheimer's disease (AD), exemplified by the identification of coding variants in triggering receptor expressed on myeloid cells 2 (TREM2) and, more recently, in
Autor:
Dylan Garceau, Jennifer D. Whitesell, Julie A. Harris, Hilda Solanoy, Hoang Nguyen, Gilbert Di Paolo, Connie W.Y. Ha, Robert G. Thorne, Meredith E. K. Calvert, Joseph W. Lewcock, Karin Lin, Roni Chau, Thomas Sandmann, Sarah L. DeVos, Steve Lianoglou, Michael Sasner, Michelle E. Pizzo, Richard H. Liang, Jason C. Dugas, Jung H. Suh, Elliot R. Thomsen, Timothy K. Earr, Chia-Ching Lin, Kimberly Scearce-Levie, Dan Xia, Sonnet S. Davis, Shababa T. Masoud, Pascal E. Sanchez, Ernie Yulyaningsih
Microglial dysfunction is believed to play a pathogenic role in Alzheimer’s disease (AD). Here, we characterize the amyloid-β related pathology and microglial responses in an engineered APP knock-in mouse model of familial AD. This model recapitul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::740621cd30fb1a8feec1aa4ace66f9b6
https://doi.org/10.1101/2021.01.19.426731
https://doi.org/10.1101/2021.01.19.426731