Modelling of ciprofloxacin killing enhanced by hyperbaric oxygen treatment in Pseudomonas aeruginosa PAO1 biofilms.

Autor: Peter Alexander Vistar Gade, Terkel Bo Olsen, Peter Østrup Jensen, Mette Kolpen, Niels Høiby, Kaj-Åge Henneberg, Thomas Sams

Publikováno v: PLoS ONE, Vol 13, Iss 6, p e0198909 (2018)

OUTLINE:In chronic lung infections by Pseudomonas aeruginosa (PA) the bacteria thrive in biofilm structures protected from the immune system of the host and from antibiotic treatment. Increasing evidence suggests that the susceptibility of the bacter

Externí odkaz: https://doaj.org/article/5d4d20cd55a84ed9b9056c447de3402c

How fast is a collective bacterial state established?

Autor: Mikkel Lindstrøm Sørensen, Peter Dahl, Thomas Sams

Publikováno v: PLoS ONE, Vol 12, Iss 6, p e0180199 (2017)

Bacteria in a biofilm colony have the capacity to monitor the size and growth conditions for the colony and modify their phenotypical behaviour to optimise attacks, defence, migration, etc. The quorum sensing systems controlling this involve producti

Externí odkaz: https://doaj.org/article/d196692ddaae40f18508d4cb10628e37

Diffusion Retardation by Binding of Tobramycin in an Alginate Biofilm Model.

Autor: Bao Cao, Lars Christophersen, Mette Kolpen, Peter Østrup Jensen, Kim Sneppen, Niels Høiby, Claus Moser, Thomas Sams

Publikováno v: PLoS ONE, Vol 11, Iss 4, p e0153616 (2016)

Microbial cells embedded in a self-produced extracellular biofilm matrix cause chronic infections, e. g. by Pseudomonas aeruginosa in the lungs of cystic fibrosis patients. The antibiotic killing of bacteria in biofilms is generally known to be reduc

Externí odkaz: https://doaj.org/article/a9685583fa8941c1b20632d304540ce0

Formation of Pseudomonas aeruginosa inhibition zone during tobramycin disk diffusion is due to transition from planktonic to biofilm mode of growth

Autor: Thomas Bjarnsholt, Kaj-Åge Henneberg, Oana Ciofu, Ulla Johansen, Camilla Stavnsbjerg, Hengshuang Wang, Thomas Sams, Niels Høiby

Publikováno v: Høiby, N, Henneberg, K Å, Wang, H, Stavnsbjerg, C, Bjarnsholt, T, Ciofu, O, Johansen, U R & Sams, T 2019, ' Formation of Pseudomonas aeruginosa inhibition zone during tobramycin disk diffusion is due to transition from planktonic to biofilm mode of growth ', International Journal of Antimicrobial Agents, vol. 53, no. 5, pp. 564-573 . https://doi.org/10.1016/j.ijantimicag.2018.12.015
Høiby, N, Henneberg, K-Å, Wang, H, Stavnsbjerg, C, Bjarnsholt, T, Ciofu, O, Johansen, U R & Sams, T 2019, ' Formation of Pseudomonas aeruginosa inhibition zone during Tobramycin disk diffusion is due to a transition from planktonic to biofilm mode of growth ', International Journal of Antimicrobial Agents, vol. 53, no. 5, pp. 564-573 . https://doi.org/10.1016/j.ijantimicag.2018.12.015

Pseudomonas aeruginosa PAO1 (tobramycin MIC = 0.064 µg/mL) was used to perform agar diffusion tests employing tobramycin-containing tablets. Bacterial growth and formation of inhibition zones were studied by stereomicroscopy and by blotting with mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb45f83b0853f44f39a5a4eacb72ffa8
https://doi.org/10.1016/j.ijantimicag.2018.12.015

Origin of cooperativity in the activation of dimeric transcription factors

Autor: Thomas Sams, Christopher T. Workman, Martin Welch, Jens Christian Brasen

Publikováno v: Welch, M, Brasen, J C, Workman, C & Sams, T 2020, ' Origin of cooperativity in the activation of dimeric transcription factors ', Physical Review Research, vol. 2, no. 1, 013151 . https://doi.org/10.1103/PhysRevResearch.2.013151

Cooperative behavior in the binding of ligands to a protein is often viewed as a complex phenomenon where conformational changes induced by the binding of the first ligand leads to tighter binding of subsequent ligands. We revisit the ligand-dependen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd75be3a28aad2c2980d5d7acdd2d76b
https://doi.org/10.1103/physrevresearch.2.013151