Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Thomas S. Watkins"'
Autor:
Harshi Weerakoon, Ahmed Mohamed, Yide Wong, Jinjin Chen, Bhagya Senadheera, Oscar Haigh, Thomas S. Watkins, Stephen Kazakoff, Pamela Mukhopadhyay, Jason Mulvenna, John J. Miles, Michelle M. Hill, Ailin Lepletier
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Engagement of the T cell receptor (TCR) triggers molecular reprogramming leading to the acquisition of specialized effector functions by CD4 helper and CD8 cytotoxic T cells. While transcription factors, chemokines, and cytokines are known d
Externí odkaz:
https://doaj.org/article/6c5f2dbb912e4bc28c94d62032105a3d
Autor:
Harshi Weerakoon, Ahmed Mohamed, Yide Wong, Bhagya Senadheera, Oscar Haigh, Thomas S. Watkins, Stephen Kazakoff, Pamela Mukhopadhyay, Jason Mulvenna, John J. Miles, Michelle M. Hill, Ailin Lepletier
T-cells are critical components of the adaptive immune system. Upon activation, they acquire effector functions through a complex interplay between mRNA transcripts and proteins, the landscape of which remains to be fully elucidated. In this resource
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6141bf6f059f95e006eee8475c80a0c
https://doi.org/10.1101/2023.03.17.532022
https://doi.org/10.1101/2023.03.17.532022
Autor:
Frederic Sierro, Umaimainthan Palendira, Asolina Braun, Angela Ferguson, Tomoki Ohashi, Thomas S. Watkins, Carl G. Feng, Georgia Gasparini, John J. Miles, Warwick J. Britton, Rehana Hewavisenti, Stuart G. Tangye, Thomas Gebhardt, Michael Elliott
Publikováno v:
Immunology & Cell Biology. 99:894-906
Regulatory T cells (Tregs) play a critical role in immune regulation and peripheral tolerance. While different types of Tregs have been identified in both mice and humans, much of our understanding about how these cells maintain immune homeostasis is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e517f82084e0572f5f6651e2ce92538
https://doi.org/10.1111/imcb.12481
https://doi.org/10.1111/imcb.12481
Autor:
John J. Miles, Thomas S Watkins
Publikováno v:
Immunology & Cell Biology. 99:135-145
The adaptive immune system arose 600 million years ago in a cold-blooded fish. Over countless generations, our antecedents tuned the function of the T-cell receptor (TCR). The TCR system is arguably the most complex known to science. The TCR evolved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36829ad8a43d99c73851953f6be142aa
https://doi.org/10.1111/imcb.12377
https://doi.org/10.1111/imcb.12377
Autor:
Ben Cristofori-Armstrong, Severine Navarro, Alex Loukas, Richard J. Clark, Jason Mulvenna, Taylor B. Smallwood, John J. Miles, Viviana P. Lutzky, Rachael Y.M. Ryan, Oscar Haigh, K. Johan Rosengren, Thomas S. Watkins, Katie Tungatt
Publikováno v:
The Journal of Biological Chemistry
The prevalence of autoimmune diseases is on the rise globally. Currently, autoimmunity presents in over 100 different forms and affects around 9% of the world’s population. Current treatments available for autoimmune diseases are inadequate, expens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84cff48ea15305ca429d158c4157538c
https://pubmed.ncbi.nlm.nih.gov/34051231
https://pubmed.ncbi.nlm.nih.gov/34051231
Autor:
Domenica A. McCarthy, Justen Cracraft, Mikael Knip, Aowen Zhuang, Nicole B. Flemming, John J. Miles, Thomas S. Watkins, Kristen J. Radford, Casper G. Schalkwijk, Per-Henrik Groop, Josephine M. Forbes, Raymond J. Steptoe, Amelia K. Fotheringham, Jean L.J.M. Scheijen, Tamar E. Boursalian, Danielle J. Borg, Sherman S. Leung
Type 1 diabetes (T1D) is an autoimmune disease with no cure. Therapeutic translation has been hampered by preclinical reproducibility. Here, short-term administration of an antagonist to the receptor for advanced glycation end products (sRAGE) protec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e6e5246ebcfb308c1125380fa8bdfa1
https://doi.org/10.1101/2020.01.10.902627
https://doi.org/10.1101/2020.01.10.902627
Autor:
Corey Smith, Champa N. Ratnatunga, Nicola Waddell, Thomas S. Watkins, Mark J. Smyth, Viviana P. Lutzky, William C. Dougall, Deepak Mittal, Roslyn A. Kemp, Pamela Mukhopadhyay, Kimberley Stannard, Ailin Lepletier, Helen M. McGuire, John J. Miles
CD96 has recently been shown to be a potent immune checkpoint molecule in\ud mice, but a similar role in humans is not known. In this study, we provide a\ud detailed map of CD96 expression across human lymphocyte lineages, the\ud kinetics of CD96 reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f63cf8a143b585d16f5531deda7fc5
Autor:
Chek Meng Poh, Rebecca J. Faleiro, Jason Sang Hun Lee, Johnny X. Huang, Patrick J. Dwyer, James S. McCarthy, Joshua M. Horne-Debets, Michael Yarski, John J. Miles, Chiuan Yee Leow, Arlene H. Sharpe, Fiona H. Amante, Deshapriya S. Karunarathne, Michelle N. Wykes, Katryn J. Stacey, Laurent Rénia, Mark E. Cooper, Thomas S. Watkins, Derek J. Richard
Publikováno v:
Immunity. 45:333-345
Many pathogens, including Plasmodium spp., exploit the interaction of programmed death-1 (PD-1) with PD-1-ligand-1 (PD-L1) to "deactivate" T cell functions, but the role of PD-L2 remains unclear. We studied malarial infections to understand the contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4742d4a78b0135a7f8973ca625e9668
https://doi.org/10.1016/j.immuni.2016.07.017
https://doi.org/10.1016/j.immuni.2016.07.017
Autor:
Kwok Soon Wun, Jacob A. Mayfield, Josephine F. Reijneveld, Dale I. Godfrey, David Price, Kattya Lopez Tamara, Sarah K. Iwany, Megan Murray, Kelly L. Miners, Tan Yun Cheng, James E. McLaren, Stephanie Gras, Kristin Ladell, Segundo R. Leon, Oscar Haigh, Judith Jimenez, D. Branch Moody, John J. Miles, Anthony W. Purcell, Sara Suliman, Ildiko Van Rhijn, Adam P Uldrich, Jérôme Le Nours, Emma J. Grant, Roger Calderon, John D. Altman, Thomas S. Watkins, Jamie Rossjohn
Publikováno v:
Nature Immunology, 19(4). Nature Publishing Group
The hallmark function of αβ T cell antigen receptors (TCRs) involves the highly specific co-recognition of a major histocompatibility complex molecule and its carried peptide. However, the molecular basis of the interactions of TCRs with the lipid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ffe214302ec436449dc781b4a6342f
https://pubmed.ncbi.nlm.nih.gov/29563628
https://pubmed.ncbi.nlm.nih.gov/29563628
Autor:
Thomas S. Watkins, Andrew Farmer, John J. Miles, Barbara Fazekas de St Groth, Nao Yasuyama, Matthew A. Field, Sarah Taylor, Helen M. McGuire
Publikováno v:
Immunology and cell biology. 96(6)
The utility of T-cell receptor (TCR) transgenic mice in medical research has been considerable, with applications ranging from basic biology all the way to translational and clinical investigations. Crossing of TCR transgenic mice with either recombi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8a30cf0db8dc6d2a865ae30cc06687
https://pubmed.ncbi.nlm.nih.gov/29573470
https://pubmed.ncbi.nlm.nih.gov/29573470