Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Thomas S. Stewart"'
Publikováno v:
Europe PubMed Central
The cytidine triphosphate synthetase genes from three diverse strains of Giardia duodenalis have been sequenced and found to vary significantly from one another. The isolates were chosen as representatives of three demes as determined by several crit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af003c1fba2ead36f8da25924d09c7e
https://doi.org/10.1111/j.1550-7408.1997.tb05957.x
https://doi.org/10.1111/j.1550-7408.1997.tb05957.x
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1399:213-218
Using degenerate oligonucleotides derived from conserved amino acid regions of cytidine triphosphate synthetase, a fragment of the gene from the malarial parasite, Plasmodium falciparum, was isolated by polymerase chain reaction (PCR). This fragment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e2a0541e155dbc6d2b70b3ec1cc9689
https://doi.org/10.1016/s0167-4781(98)00108-0
https://doi.org/10.1016/s0167-4781(98)00108-0
Publikováno v:
Molecular and Biochemical Parasitology. 68:315-318
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8567e69981416eba0fa82b12d2d45374
https://doi.org/10.1016/0166-6851(94)90176-7
https://doi.org/10.1016/0166-6851(94)90176-7
Autor:
William J. O'Sullivan, Thomas S. Stewart, Edward F. Hendriks, Ping Yuan, Harvey Robert Fernandez
Publikováno v:
Molecular and biochemical parasitology. 143(2)
CTP synthetase (E C 6.3.4.2 UTP: ammonia ligase (ADP-forming)) catalyses the formation of CTP from UTP and, in the human parasite Plasmodium falciparum, is the sole source of cytidine nucleotides. It is thus a potential chemotherapeutic target, espec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed92bf14b44f03f3fc544412816da7c
https://pubmed.ncbi.nlm.nih.gov/16051382
https://pubmed.ncbi.nlm.nih.gov/16051382
Publikováno v:
Scopus-Elsevier
Antisense oligonucleotides and ribozymes have shown promise both as antimalarial agents and as tools for identifying genes vital for parasite survival. This task is urgent due to the ineffectiveness of current drug regimes on the most virulent human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35dc2801d8dce34391401cd812546cf6
https://pubmed.ncbi.nlm.nih.gov/10494816
https://pubmed.ncbi.nlm.nih.gov/10494816
Publikováno v:
Experimental parasitology. 88(3)
Flores, M. V. C., and Stewart, T. S. 1998.Plasmodium falciparum: A microassay for the malarial carbamoyl phosphate synthetase.Experimental Parasitology88, 243–245.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83467e6c8fdcc7c8de8fb2a10691091e
https://pubmed.ncbi.nlm.nih.gov/9562429
https://pubmed.ncbi.nlm.nih.gov/9562429
Publikováno v:
The Journal of biological chemistry. 273(8)
Arginine deiminase (EC 3.5.3.6) catalyzes the irreversible catabolism of arginine to citrulline in the arginine dihydrolase pathway. This pathway has been regarded as restricted to prokaryotic organisms but is an important source of energy to the pri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c9b99bc4b538622bfb53f2519f11d8
https://pubmed.ncbi.nlm.nih.gov/9468500
https://pubmed.ncbi.nlm.nih.gov/9468500
Publikováno v:
The Journal of biological chemistry. 272(27)
Catalytic RNA (ribozymes) suppressed the growth of the human malarial parasite Plasmodium falciparum in vitro. The phosphorothioated hammerhead ribozymes targeted unique regions of the P. falciparum carbamoyl-phosphate synthetase II gene. The P. falc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32085eeb22c898da19ef6a03df2b72d7
https://pubmed.ncbi.nlm.nih.gov/9202005
https://pubmed.ncbi.nlm.nih.gov/9202005
Publikováno v:
Parasitology research. 83(7)
Continuous cultivation of both drug-sensitive and drug-resistant strains of Plasmodium falciparum was achieved using a mixture of commercially available serum substitutes. This provides easier standardisation of experimental data and minimises the ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1c300ac09f892c54d938895eba710db
https://pubmed.ncbi.nlm.nih.gov/9272569
https://pubmed.ncbi.nlm.nih.gov/9272569
Publikováno v:
Molecular and biochemical parasitology. 78(1-2)
The cytidine triphosphate synthetase gene from Giardia intestinalis was cloned using a PCR-based strategy. A 519 bp PCR product was obtained from the amplification of genomic DNA using two oligonucleotides derived from the CTP synthetase amino acid c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59eecd385f9b3685c51f7b8c51da58ee
https://pubmed.ncbi.nlm.nih.gov/8813694
https://pubmed.ncbi.nlm.nih.gov/8813694