Zobrazeno 1 - 10
of 332
pro vyhledávání: '"Thomas S. Jacques"'
Autor:
John R. Apps, Jose Mario Gonzalez-Meljem, Romain Guiho, Jessica C. Pickles, Eric Prince, Edward Schwalbe, Nikhil Joshi, Thomas J. Stone, Olumide Ogunbiyi, Jane Chalker, Akang Bassey, Georg Otto, Rosalind Davies, Debbie Hughes, Sebastian Brandner, Enrica Tan, Victoria Lee, Caroline Hayhurst, Cassie Kline, Sergi Castellano, Todd Hankinson, Timo Deutschbein, Thomas S. Jacques, Juan Pedro Martinez-Barbera
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-15 (2024)
Abstract The two types of craniopharyngioma, adamantinomatous (ACP) and papillary (PCP), are clinically relevant tumours in children and adults. Although the biology of primary craniopharyngioma is starting to be unravelled, little is known about the
Externí odkaz:
https://doaj.org/article/0874ef81d5794b778ecf6f36f0dcbfe2
Autor:
Analiz Rodriguez, Manmeet S. Ahluwalia, Chetan Bettegowda, Henry Brem, Bob S. Carter, Susan Chang, Sunit Das, Charles Eberhart, Tomas Garzon-Muvdi, Costas G. Hadjipanayis, Cynthia Hawkins, Thomas S. Jacques, Alexander A. Khalessi, Michael W. McDermott, Tom Mikkelsen, Brent A. Orr, Joanna J. Phillips, Mark Rosenblum, William J. Shelton, David A. Solomon, Andreas von Deimling, Graeme F. Woodworth, James T. Rutka
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Implementation of standardized protocols in neurooncology during the surgical resection of brain tumors is needed to advance the clinical treatment paradigms that use tissue for diagnosis, prognosis, bio-banking, and treatment. Currently recommendati
Externí odkaz:
https://doaj.org/article/14b96e8f80cc473abe5955a6777b64fa
Autor:
Philipp Sievers, Martin Sill, Daniel Schrimpf, Zied Abdullaev, Andrew M. Donson, Jessica A. Lake, Dennis Friedel, David Scheie, Olli Tynninen, Tuomas Rauramaa, Kaisa L. Vepsäläinen, David Samuel, Rebecca Chapman, Richard G. Grundy, Kristian W. Pajtler, Arnault Tauziède-Espariat, Alice Métais, Pascale Varlet, Matija Snuderl, Thomas S. Jacques, Kenneth Aldape, David E. Reuss, Andrey Korshunov, Wolfgang Wick, Stefan M. Pfister, Andreas von Deimling, Felix Sahm, David T. W. Jones
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-8 (2023)
Abstract Pediatric neoplasms in the central nervous system (CNS) show extensive clinical and molecular heterogeneity and are fundamentally different from those occurring in adults. Molecular genetic testing contributes to accurate diagnosis and enabl
Externí odkaz:
https://doaj.org/article/9f54e4ebe7994704862580e7e4db4d5b
Autor:
Yura Grabovska, Alan Mackay, Patricia O’Hare, Stephen Crosier, Martina Finetti, Edward C. Schwalbe, Jessica C. Pickles, Amy R. Fairchild, Aimee Avery, Julia Cockle, Rebecca Hill, Janet Lindsey, Debbie Hicks, Mark Kristiansen, Jane Chalker, John Anderson, Darren Hargrave, Thomas S. Jacques, Karin Straathof, Simon Bailey, Chris Jones, Steven C. Clifford, Daniel Williamson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Here, using methylCIBERSORT, the authors characterize the tumour-immune microenvironment of paediatric central nervous system (CNS) tumours and its association with tumour type and prognosis. These findings suggest that immuno-methylomic profiling ma
Externí odkaz:
https://doaj.org/article/ec15b2c4e08f447294d1c85b886169aa
Autor:
Sara Lorio, Jan Sedlacik, Po-Wah So, Harold G. Parkes, Roxana Gunny, Ulrike Löbel, Yao-Feng Li, Olumide Ogunbiyi, Talisa Mistry, Emma Dixon, Sophie Adler, J. Helen Cross, Torsten Baldeweg, Thomas S. Jacques, Karin Shmueli, David W Carmichael
Publikováno v:
NeuroImage, Vol 238, Iss , Pp 118102- (2021)
Objective: Malformations of cortical development (MCD), including focal cortical dysplasia (FCD), are the most common cause of drug-resistant focal epilepsy in children. Histopathological lesion characterisation demonstrates abnormal cell types and l
Externí odkaz:
https://doaj.org/article/ec6b134050a74e128716af29f14126b8
Autor:
Jose Mario Gonzalez-Meljem, Scott Haston, Gabriela Carreno, John R. Apps, Sara Pozzi, Christina Stache, Grace Kaushal, Alex Virasami, Leonidas Panousopoulos, Seyedeh Neda Mousavy-Gharavy, Ana Guerrero, Mamunur Rashid, Nital Jani, Colin R. Goding, Thomas S. Jacques, David J. Adams, Jesus Gil, Cynthia L. Andoniadou, Juan Pedro Martinez-Barbera
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Senescent cells can promote tumour progression through the activation of a senescenceassociated secretory phenotype (SASP). Here, the authors show that SASP activation is associated with non-cell autonomous cell transformation and tumour initiation i
Externí odkaz:
https://doaj.org/article/a0474958863a4634a3e1c6faf8951dc5
Autor:
Sophie Adler, Sara Lorio, Thomas S. Jacques, Barbora Benova, Roxana Gunny, J. Helen Cross, Torsten Baldeweg, David W. Carmichael
Publikováno v:
NeuroImage: Clinical, Vol 15, Iss , Pp 95-105 (2017)
Focal cortical dysplasias (FCDs) are a range of malformations of cortical development each with specific histopathological features. Conventional radiological assessment of standard structural MRI is useful for the localization of lesions but is unab
Externí odkaz:
https://doaj.org/article/76b71ddf474b4e4aac3662d4534d4f42
Autor:
John R. Apps, J. Ciaran Hutchinson, Susan Shelmerdine, Alex Virasami, Eduard Winter, Thomas S. Jacques, Juan-Pedro Martinez-Barbera, Owen Arthurs, Thomas Czech
Publikováno v:
F1000Research, Vol 8 (2019)
This manuscript describes the study of two cases of craniopharyngioma, which have been examined repeatedly over three separate centuries. This includes analysis by Josef Engel in 1839, who sought to uncover the physiological role of the pituitary gla
Externí odkaz:
https://doaj.org/article/e1f70f2e62ee42b18c173a2382433568
Autor:
Karin Tuschl, Esther Meyer, Leonardo E. Valdivia, Ningning Zhao, Chris Dadswell, Alaa Abdul-Sada, Christina Y. Hung, Michael A. Simpson, W. K. Chong, Thomas S. Jacques, Randy L. Woltjer, Simon Eaton, Allison Gregory, Lynn Sanford, Eleanna Kara, Henry Houlden, Stephan M. Cuno, Holger Prokisch, Lorella Valletta, Valeria Tiranti, Rasha Younis, Eamonn R. Maher, John Spencer, Ania Straatman-Iwanowska, Paul Gissen, Laila A. M. Selim, Guillem Pintos-Morell, Wifredo Coroleu-Lletget, Shekeeb S. Mohammad, Sangeetha Yoganathan, Russell C. Dale, Maya Thomas, Jason Rihel, Olaf A. Bodamer, Caroline A. Enns, Susan J. Hayflick, Peter T. Clayton, Philippa B. Mills, Manju A. Kurian, Stephen W. Wilson
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Karin Tuschl, Philippa Mills and colleagues report mutations in the manganese (Mn) transporter gene SLC39A14in childhood-onset parkinsonism-dystonia. Using functional recapitulation, the authors also show that slc39A14 loss-of-function in zebrafish c
Externí odkaz:
https://doaj.org/article/122cc65e3ed24026b35cd38223a5fe6b
Autor:
Nicola Potter, Aikaterini Karakoula, Kim P. Phipps, William Harkness, Richard Hayward, Dominic N.P. Thompson, Thomas S. Jacques, Brian Harding, David G.T. Thomas, Rodger W. Palmer, Jeremy Rees, John Darling, Tracy J. Warr
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 8, Pp 757-772 (2008)
The molecular pathogenesis of pediatric pilocytic astrocytoma (PA) is not well defined. Previous cytogenetic and molecular studies have not identified nonrandom genetic aberrations. To correlate differential gene expression and genomic copy number ab
Externí odkaz:
https://doaj.org/article/6c7d87bb852544ab9dcb9da2a2d3a64f