Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Thomas S. Blacker"'
Autor:
Noemí Esteras, Thomas S. Blacker, Evgeny A. Zherebtsov, Olga A. Stelmashuk, Ying Zhang, W. Christian Wigley, Michael R. Duchen, Albena T. Dinkova-Kostova, Andrey Y. Abramov
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102672- (2023)
The transcription factor Nrf2 and its repressor Keap1 mediate cell stress adaptation by inducing expression of genes regulating cellular detoxification, antioxidant defence and energy metabolism. Energy production and antioxidant defence employ NADH
Externí odkaz:
https://doaj.org/article/4123d5a1ee434661a0e1f99bf4759861
Autor:
Luke W. Thomas, Cinzia Esposito, Jenna M. Stephen, Ana S. H. Costa, Christian Frezza, Thomas S. Blacker, Gyorgy Szabadkai, Margaret Ashcroft
Publikováno v:
Cancer & Metabolism, Vol 7, Iss 1, Pp 1-17 (2019)
Abstract Background Mitochondrial oxidative phosphorylation (OXPHOS) via the respiratory chain is required for the maintenance of tumour cell proliferation and regulation of epithelial to mesenchymal transition (EMT)-related phenotypes through mechan
Externí odkaz:
https://doaj.org/article/32815a8ddeae44589ff3985f781b2f2a
Autor:
Elizabeth Haythorne, Maria Rohm, Martijn van de Bunt, Melissa F. Brereton, Andrei I. Tarasov, Thomas S. Blacker, Gregor Sachse, Mariana Silva dos Santos, Raul Terron Exposito, Simon Davis, Otto Baba, Roman Fischer, Michael R. Duchen, Patrik Rorsman, James I. MacRae, Frances M. Ashcroft
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Pancreatic beta-cell glucose metabolism is coupled to insulin secretion. Here the authors set out to characterize changes in beta-cell metabolism in hyperglycemia which may contribute to insufficient insulin secretion in type 2 diabetes and, using a
Externí odkaz:
https://doaj.org/article/e58a88780c484df287e145eadffc1041
Autor:
Anna Tosatto, Roberta Sommaggio, Carsten Kummerow, Robert B Bentham, Thomas S Blacker, Tunde Berecz, Michael R Duchen, Antonio Rosato, Ivan Bogeski, Gyorgy Szabadkai, Rosario Rizzuto, Cristina Mammucari
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 5, Pp 569-585 (2016)
Abstract Triple‐negative breast cancer (TNBC) represents the most aggressive breast tumor subtype. However, the molecular determinants responsible for the metastatic TNBC phenotype are only partially understood. We here show that expression of the
Externí odkaz:
https://doaj.org/article/772fae7597ff450391056d14ec5509ff
Autor:
James DB O’Sullivan, Thomas S Blacker, Claire Scott, Weise Chang, Mohi Ahmed, Val Yianni, Zoe F Mann
In vertebrates with elongated auditory organs, mechanosensory hair cells (HCs) are organised such that complex sounds are broken down into their component frequencies along the basal-to-apical long (tonotopic) axis. Acquisition of frequency-specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::408b2bcc859c037e6f92343691d84038
https://doi.org/10.1101/2022.04.11.487851
https://doi.org/10.1101/2022.04.11.487851
Autor:
Carrie A. Ambler, Rachel Humann, Joshua G Hughes, Thomas S. Blacker, Candace Adams, Andrew Whiting, Daniel Callaghan, John M. Girkin, Nicola K Lembicz, Alba Pujol, David R. Chisholm, Angus J. Bain
Publikováno v:
Organicbiomolecular chemistry. 18(45)
Fluorescent probes are increasingly used as reporter molecules in a wide variety of biophysical experiments, but when designing new compounds it can often be difficult to anticipate the effect that changing chemical structure can have on cellular loc
Decellularized Cartilage Directs Chondrogenic Differentiation: Creation of a Fracture Callus Mimetic
Autor:
Scott J. Roberts, Paul Sibbons, Michael R. Duchen, Thomas S. Blacker, Mittal Shah, Wollis J Vas
Publikováno v:
Tissue Engineering Part A. 24:1364-1376
Complications that arise from impaired fracture healing have considerable socioeconomic implications. Current research in the field of bone tissue engineering predominantly aims to mimic the mature bone tissue microenvironment. This approach, however
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
An increasing volume of data suggests that changes in cellular metabolism have a major impact on the health of tissues and organs, including in the auditory system where metabolic alterations are implicated in both age-related and noise-induced heari
Publikováno v:
The journal of physical chemistry. B. 123(22)
[Image: see text] Two-photon absorption (2PA) finds widespread application in biological systems, which frequently exhibit heterogeneous fluorescence decay dynamics corresponding to multiple species or environments. By combining polarized 2PA with ti
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1928
Altered metabolism is a hallmark of cancer, both resulting from and driving oncogenesis. The NAD and NADP redox couples play a key role in a large number of the metabolic pathways involved. In their reduced forms, NADH and NADPH, these molecules are