Zobrazeno 1 - 10
of 263
pro vyhledávání: '"Thomas S Scanlan"'
Autor:
Greg J. Duncan, Sam D. Ingram, Katie Emberley, Jo Hill, Christian Cordano, Ahmed Abdelhak, Michael McCane, Jennifer E. Jenks, Nora Jabassini, Kirtana Ananth, Skylar J. Ferrara, Brittany Stedelin, Benjamin Sivyer, Sue A. Aicher, Thomas S. Scanlan, Trent A. Watkins, Anusha Mishra, Jonathan W. Nelson, Ari J. Green, Ben Emery
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Chronic demyelination and oligodendrocyte loss deprive neurons of crucial support. It is the degeneration of neurons and their connections that drives progressive disability in demyelinating disease. However, whether chronic demyelination tr
Externí odkaz:
https://doaj.org/article/157dbf6e704c453ab56f2275e3086749
Autor:
Víctor Valcárcel-Hernández, Marina Guillén-Yunta, Thomas S. Scanlan, Soledad Bárez-López, Ana Guadaño-Ferraz
Publikováno v:
Thyroid. 33:632-640
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2243a5353100ffe8402984b1ee084f5e
https://doi.org/10.1089/thy.2022.0612
https://doi.org/10.1089/thy.2022.0612
Akademický článek
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Autor:
Joseph F Bohlen, Colin M Cleary, Debamitra Das, Srinidhi Rao Sripathy, Norah Sadowski, Gina Shim, Rakaia F Kenney, Ingrid P Buchler, Tapasree Banerji, Thomas S Scanlan, Daniel K Mulkey, Brady J Maher
Publikováno v:
Brain.
Pitt–Hopkins syndrome is an autism spectrum disorder caused by autosomal dominant mutations in the human transcription factor 4 gene (TCF4). One pathobiological process caused by murine Tcf4 mutation is a cell autonomous reduction in oligodendrocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::843f3974dec634234553a8ce35509265
https://doi.org/10.1093/brain/awad057
https://doi.org/10.1093/brain/awad057
Autor:
Thomas S. Scanlan, Skylar J. Ferrara
Publikováno v:
Journal of Medicinal Chemistry. 63:9742-9751
The blood-brain barrier is a major impediment for targeted central nervous system (CNS) therapeutics, especially with carboxylic acid-containing drugs. Nuclear receptor modulators, which often feature carboxylic acid motifs for target engagement, hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd7185869747fefeae33b5558769dd5b
https://doi.org/10.1021/acs.jmedchem.0c00868
https://doi.org/10.1021/acs.jmedchem.0c00868
Autor:
Priya Chaudhary, Dennis Bourdette, Edvinas Pocius, Evan Calkins, Ben Emery, Gail Marracci, Thomas S. Scanlan, AeSoon L. Bensen
Publikováno v:
J Neuroimmunol
We have previously demonstrated that thyromimetics stimulate oligodendrocyte precursor cell differentiation and promote remyelination in murine demyelination models. We investigated whether a thyroid receptor-beta selective thyromimetic, sobetirome (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7599bb2a5f4594301b4f60c51eda8f
https://doi.org/10.1101/2020.12.20.423638
https://doi.org/10.1101/2020.12.20.423638
Autor:
Priya Chaudhary, Thomas S. Scanlan, Edvinas Pocius, Brooke A. Napier, Gail Marracci, Hannah Miller, Skylar J. Ferrara, Evan Calkins, Dennis Bourdette, Margaret J. DeBell, Ben Emery
Publikováno v:
Cell Chem Biol
bioRxiv
bioRxiv
Triggering receptor expressed on myeloid cells-2 (TREM2) is a cell surface receptor on macrophages and microglia that senses and responds to disease associated signals to regulate the phenotype of these innate immune cells. The TREM2 signaling pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dffff4f8366c45fdf17852fb41997a6
https://doi.org/10.1016/j.chembiol.2021.07.014
https://doi.org/10.1016/j.chembiol.2021.07.014
Publikováno v:
Endocrinology. 159:2733-2740
Thyromimetics represent a class of experimental drugs that can stimulate tissue-selective thyroid hormone action. As such, thyromimetics should have effects on the hypothalamic-pituitary-thyroid (HPT) axis, but details of this action and the subseque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae48cab23a3e5b17191e203b36adeddd
https://doi.org/10.1210/en.2018-00065
https://doi.org/10.1210/en.2018-00065
Autor:
Thomas S. Scanlan, Xinran Liu, Tony Woolard, Jose D. Herazo-Maya, Antonio C. Bianco, Robert J. Homer, Erica L. Herzog, Guoying Yu, Farida Ahangari, Nachelle Aurelien, Rong Wang, Naftali Kaminski, Morven Graham, Gabriel Ibarra, Rafael Arrojo e Drigo, Joao Pedro Werneck de Castro, Argyris Tzouvelekis, Anup Srivastava, Ye Gan, Giuseppe DeIuliis, Patty J. Lee, Praveen Mannam
Publikováno v:
Nature medicine
Thyroid hormone (TH) is critical for the maintenance of cellular homeostasis during stress responses, but its role in lung fibrosis is unknown. Here we found that the activity and expression of iodothyronine deiodinase 2 (DIO2), an enzyme that activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70bb2d3044aa6c23363a0e04d475d3fa
https://doi.org/10.1038/nm.4447
https://doi.org/10.1038/nm.4447
Autor:
Tapasree Banerji, Skylar J. Ferrara, Hannah Sanford-Crane, Tania Banerji, Thomas S. Scanlan, J. Matthew Meinig, Dennis Bourdette
Publikováno v:
ACS Chemical Neuroscience. 8:2468-2476
The blood-brain barrier (BBB) can be a substantial impediment to achieving therapeutic levels of drugs in the CNS. Certain chemical functionality such as the carboxylic acid is a general liability for BBB permeability preventing significant CNS distr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d39b7aabe18e38093b801636ba00b4
https://doi.org/10.1021/acschemneuro.7b00239
https://doi.org/10.1021/acschemneuro.7b00239