Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Thomas S Brettin"'
Autor:
Nicholas A Be, James B Thissen, Shea N Gardner, Kevin S McLoughlin, Viacheslav Y Fofanov, Heather Koshinsky, Sally R Ellingson, Thomas S Brettin, Paul J Jackson, Crystal J Jaing
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73455 (2013)
Bacillus anthracis is the potentially lethal etiologic agent of anthrax disease, and is a significant concern in the realm of biodefense. One of the cornerstones of an effective biodefense strategy is the ability to detect infectious agents with a hi
Externí odkaz:
https://doaj.org/article/972415363fa243d39d48d05a0f2daf9f
Autor:
Konstantinos Mavromatis, Miriam L Land, Thomas S Brettin, Daniel J Quest, Alex Copeland, Alicia Clum, Lynne Goodwin, Tanja Woyke, Alla Lapidus, Hans Peter Klenk, Robert W Cottingham, Nikos C Kyrpides
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e48837 (2012)
BackgroundThe emergence of next generation sequencing (NGS) has provided the means for rapid and high throughput sequencing and data generation at low cost, while concomitantly creating a new set of challenges. The number of available assembled micro
Externí odkaz:
https://doaj.org/article/9b63d13f585d4aad871da6726ffa660e
Autor:
Ufuk Nalbantoglu, Khalid Sayood, Michael P Dempsey, Peter C Iwen, Stephen C Francesconi, Ravi D Barabote, Gary Xie, Thomas S Brettin, Steven H Hinrichs, Paul D Fey
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9007 (2010)
Francisella tularensis subspecies tularensis consists of two separate populations A1 and A2. This report describes the complete genome sequence of NE061598, an F. tularensis subspecies tularensis A1 isolated in 1998 from a human with clinical disease
Externí odkaz:
https://doaj.org/article/38fa669aeddf4adda1d8b300b4fe4437
Autor:
Ravi D Barabote, Gary Xie, Thomas S Brettin, Steven H Hinrichs, Paul D Fey, Justin J Jay, Jennifer L Engle, Shubhada D Godbole, Jyothi M Noronha, Richard H Scheuermann, Liwei W Zhou, Christine Lion, Michael P Dempsey
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7041 (2009)
Francisella tularensis subspecies holarctica FTNF002-00 strain was originally obtained from the first known clinical case of bacteremic F. tularensis pneumonia in Southern Europe isolated from an immunocompetent individual. The FTNF002-00 complete ge
Externí odkaz:
https://doaj.org/article/1851425325624e87982be84beb8190ee
Autor:
Theresa J Smith, Karen K Hill, Brian T Foley, John C Detter, A Christine Munk, David C Bruce, Norman A Doggett, Leonard A Smith, James D Marks, Gary Xie, Thomas S Brettin
Publikováno v:
PLoS ONE, Vol 2, Iss 12, p e1271 (2007)
BackgroundClostridium botulinum and related clostridial species express extremely potent neurotoxins known as botulinum neurotoxins (BoNTs) that cause long-lasting, potentially fatal intoxications in humans and other mammals. The amino acid variation
Externí odkaz:
https://doaj.org/article/26ac0c1186014ed1bdf64f29a1083e3d
Autor:
Stephen M Beckstrom-Sternberg, Raymond K Auerbach, Shubhada Godbole, John V Pearson, James S Beckstrom-Sternberg, Zuoming Deng, Christine Munk, Kristy Kubota, Yan Zhou, David Bruce, Jyothi Noronha, Richard H Scheuermann, Aihui Wang, Xianying Wei, Jianjun Wang, Jicheng Hao, David M Wagner, Thomas S Brettin, Nancy Brown, Paul Gilna, Paul S Keim
Publikováno v:
PLoS ONE, Vol 2, Iss 9, p e947 (2007)
Francisella tularensis is the causative agent of tularemia, which is a highly lethal disease from nature and potentially from a biological weapon. This species contains four recognized subspecies including the North American endemic F. tularensis sub
Externí odkaz:
https://doaj.org/article/a8549ea117e948b5b72c6489bc97a40c
Autor:
Raymond K Auerbach, Apichai Tuanyok, William S Probert, Leo Kenefic, Amy J Vogler, David C Bruce, Christine Munk, Thomas S Brettin, Mark Eppinger, Jacques Ravel, David M Wagner, Paul Keim
Publikováno v:
PLoS ONE, Vol 2, Iss 8, p e770 (2007)
Yersinia pestis, the etiologic agent of plague, was responsible for several devastating epidemics throughout history and is currently of global importance to current public heath and biodefense efforts. Y. pestis is widespread in the Western United S
Externí odkaz:
https://doaj.org/article/ff53150162e64b7daf85a6ef2b32c63d
Autor:
Alexander Partin, Thomas S. Brettin, Yitan Zhu, Oleksandr Narykov, Austin Clyde, Jamie Overbeek, Rick L. Stevens
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
Cancer claims millions of lives yearly worldwide. While many therapies have been made available in recent years, by in large cancer remains unsolved. Exploiting computational predictive models to study and treat cancer holds great promise in improvin
Externí odkaz:
https://doaj.org/article/62da77f2eb4342cfbd97aaecb99fd63d
Autor:
Alexander Partin, Thomas S. Brettin, Yitan Zhu, Maulik Shukla, Fangfang Xia, Hyunseung Yoo, James M Dolezal, Sara Kochanny, Alexander T. Pearson, Yvonne A. Evrard, James H. Doroshow, Rick L. Stevens
Publikováno v:
Journal of Clinical Oncology. 40:e13572-e13572
e13572 Background: Prediction of drug response is a critical research area in precision oncology and has been previously explored with large drug screening studies of cancer cell lines (CCLs). Patient-derived xenografts (PDXs) are an appealing platfo
Autor:
Yitan Zhu, Thomas S. Brettin, Alexander Partin, Fangfang Xia, Maulik Shukla, Hyunseung Yoo, Andrea Cancino, Brian Larsen, Jenna Shaxted, Ameen Salahudeen, Kevin White, Rick L. Stevens
Publikováno v:
Journal of Clinical Oncology. 40:e13544-e13544
e13544 Background: Prediction of drug response based on cancer molecular profiles is of paramount importance for precision oncology. Most existing drug response prediction models are built using drug screening data of immortalized cancer cell lines,