Zobrazeno 1 - 10
of 274
pro vyhledávání: '"Thomas S, Weiss"'
Autor:
Gayane Hrachia Buniatian, Ute Schwinghammer, Roman Tremmel, Holger Cynis, Thomas S. Weiss, Ralf Weiskirchen, Volker M. Lauschke, Sonia Youhanna, Isbaal Ramos, Maria Valcarcel, Torgom Seferyan, Jens‐Ulrich Rahfeld, Vera Rieckmann, Kathrin Klein, Marine Buadze, Victoria Weber, Valentina Kolak, Rolf Gebhardt, Scott L. Friedman, Ulrike C. Müller, Matthias Schwab, Lusine Danielyan
Publikováno v:
Advanced Science, Vol 11, Iss 18, Pp n/a-n/a (2024)
Abstract The hepatic content of amyloid beta (Aβ) decreases drastically in human and rodent cirrhosis highlighting the importance of understanding the consequences of Aβ deficiency in the liver. This is especially relevant in view of recent advance
Externí odkaz:
https://doaj.org/article/a502efb1c1864047b669d0f146231d64
Autor:
Simon Gross, Lusine Danielyan, Christa Buechler, Marion Kubitza, Kathrin Klein, Matthias Schwab, Michael Melter, Thomas S. Weiss
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8768 (2024)
Amyloid beta (Aβ) plays a major role in the pathogenesis of Alzheimer’s disease and, more recently, has been shown to protect against liver fibrosis. Therefore, we studied Aβ-42 levels and the expression of genes involved in the generation, degra
Externí odkaz:
https://doaj.org/article/dce190b90cee48cba1d81a8f5d07aecc
Autor:
Katharina Staufer, Heidemarie Huber, Jasmin Zessner-Spitzenberg, Rudolf Stauber, Armin Finkenstedt, Heike Bantel, Thomas S. Weiss, Markus Huber, Patrick Starlinger, Thomas Gruenberger, Thomas Reiberger, Susanne Sebens, Gail McIntyre, Ray Tabibiazar, Amato Giaccia, Heinz Zoller, Michael Trauner, Wolfgang Mikulits
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-8 (2023)
Abstract The expression of the receptor tyrosine kinase Axl and its cleavage product soluble Axl (sAxl) is increased in liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). In this multicenter study, we evaluated the diagnostic value of Gas
Externí odkaz:
https://doaj.org/article/6ec11fb752674d009f3b4dccfb87f223
Autor:
Katharina Schilcher, Rania Dayoub, Marion Kubitza, Jakob Riepl, Kathrin Klein, Christa Buechler, Michael Melter, Thomas S. Weiss
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13222 (2023)
Metabolic dysfunction-associated steatotic liver disease (MASLD) comprises a spectrum of liver diseases, ranging from liver steatosis to metabolic dysfunction-associated steatohepatitis (MASH), increasing the risk of developing cirrhosis and hepatoce
Externí odkaz:
https://doaj.org/article/f66b909cda2343778909fc110ea49559
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8107 (2023)
Inflammasomes and innate immune cells have been shown to contribute to liver injury, thereby activating Kupffer cells, which release several cytokines, including IL-6, IL-1ß, and TNFα. Augmenter of liver regeneration (ALR) is a hepatotropic co-mito
Externí odkaz:
https://doaj.org/article/4d3bf5e31d12455790ab2c3cb3ef28f3
Autor:
Susanne Feder, Reiner Wiest, Thomas S. Weiss, Charalampos Aslanidis, Doris Schacherer, Sabrina Krautbauer, Gerhard Liebisch, Christa Buechler
Publikováno v:
Lipids in Health and Disease, Vol 20, Iss 1, Pp 1-14 (2021)
Abstract Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is of particular importance in cholesterol metabolism with high levels contributing to hypercholesterolemia. Cholesterol and sphingolipids are low in patients with liver cirrho
Externí odkaz:
https://doaj.org/article/8716f335e93a4af38fdd8d6afcb289ae
Autor:
Kathrin Gianmoena, Nina Gasparoni, Adelina Jashari, Philipp Gabrys, Katharina Grgas, Ahmed Ghallab, Karl Nordström, Gilles Gasparoni, Jörg Reinders, Karolina Edlund, Patricio Godoy, Alexander Schriewer, Heiko Hayen, Christian A. Hudert, Georg Damm, Daniel Seehofer, Thomas S. Weiss, Peter Boor, Hans-Joachim Anders, Manga Motrapu, Peter Jansen, Tobias S. Schiergens, Maren Falk-Paulsen, Philip Rosenstiel, Clivia Lisowski, Eduardo Salido, Rosemarie Marchan, Jörn Walter, Jan G. Hengstler, Cristina Cadenas
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109526- (2021)
Summary: Epigenetic modifications (e.g. DNA methylation) in NAFLD and their contribution to disease progression and extrahepatic complications are poorly explored. Here, we use an integrated epigenome and transcriptome analysis of mouse NAFLD hepatoc
Externí odkaz:
https://doaj.org/article/8d9cdcdc3d35492a92af90d5a6d5d7cb
Autor:
Mascha Mayer, Alexander Berger, Christian Leischner, Olga Renner, Markus Burkard, Alexander Böcker, Seema Noor, Timo Weiland, Thomas S. Weiss, Christian Busch, Ulrich M. Lauer, Stephan C. Bischoff, Sascha Venturelli
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 438 (2022)
Gossypol, a sesquiterpenoid found in cotton seeds, exerts anticancer effects on several tumor entities due to inhibition of DNA synthesis and other mechanisms. In clinical oncology, histone deacetylase inhibitors (HDACi) are applied as anticancer com
Externí odkaz:
https://doaj.org/article/09e8460e1a33471d8ee405bb420c8aef
Autor:
Rebekka Pohl, Susanne Feder, Elisabeth M. Haberl, Lisa Rein-Fischboeck, Thomas S. Weiss, Marlen Spirk, Astrid Bruckmann, Nichole McMullen, Christopher J. Sinal, Christa Buechler
Publikováno v:
Biomedicines, Vol 10, Iss 1, p 132 (2022)
Non-alcoholic steatohepatitis (NASH) is marked by macrophage infiltration and inflammation. Chemerin is a chemoattractant protein and is abundant in hepatocytes. The aim of this study was to gain insight into the role of hepatocyte-produced prochemer
Externí odkaz:
https://doaj.org/article/539de5e026b348d78767ce25dfe19292
Autor:
Elisabeth M. Haberl, Thomas S. Weiss, Georg Peschel, Kilian Weigand, Nikolai Köhler, Josch K. Pauling, Jürgen J. Wenzel, Marcus Höring, Sabrina Krautbauer, Gerhard Liebisch, Christa Buechler
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5297 (2021)
Hepatocellular carcinoma (HCC) still remains a difficult to cure malignancy. In recent years, the focus has shifted to lipid metabolism for the treatment of HCC. Very little is known about hepatitis B virus (HBV) and C virus (HCV)-related hepatic lip
Externí odkaz:
https://doaj.org/article/8bff5872c0594876811a07b87bbe51ed