Výsledky vyhledávání - "Thomas Rutkowski"

Akademický článek

Pathways Linking Nicotinamide Adenine Dinucleotide Phosphate Production to Endoplasmic Reticulum Protein Oxidation and Stress

Autor: Erica R. Gansemer, D. Thomas Rutkowski

Publikováno v: Frontiers in Molecular Biosciences, Vol 9 (2022)

The endoplasmic reticulum (ER) lumen is highly oxidizing compared to other subcellular compartments, and maintaining the appropriate levels of oxidizing and reducing equivalents is essential to ER function. Both protein oxidation itself and other ess

Externí odkaz: https://doaj.org/article/38ba21c6f42344f0834d598e43aa53c7

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Akademický článek

NADPH and Glutathione Redox Link TCA Cycle Activity to Endoplasmic Reticulum Homeostasis

Autor: Erica R. Gansemer, Kyle S. McCommis, Michael Martino, Abdul Qaadir King-McAlpin, Matthew J. Potthoff, Brian N. Finck, Eric B. Taylor, D. Thomas Rutkowski

Publikováno v: iScience, Vol 23, Iss 5, Pp - (2020)

Summary: Many metabolic diseases disrupt endoplasmic reticulum (ER) homeostasis, but little is known about how metabolic activity is communicated to the ER. Here, we show in hepatocytes and other metabolically active cells that decreasing the availab

Externí odkaz: https://doaj.org/article/25bef5b0b1f54b1a9a1b238346997cb8

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Akademický článek

ER Stress Inhibits Liver Fatty Acid Oxidation while Unmitigated Stress Leads to Anorexia-Induced Lipolysis and Both Liver and Kidney Steatosis

Autor: Diane DeZwaan-McCabe, Ryan D. Sheldon, Michelle C. Gorecki, Deng-Fu Guo, Erica R. Gansemer, Randal J. Kaufman, Kamal Rahmouni, Matthew P. Gillum, Eric B. Taylor, Lynn M. Teesch, D. Thomas Rutkowski

Publikováno v: Cell Reports, Vol 19, Iss 9, Pp 1794-1806 (2017)

The unfolded protein response (UPR), induced by endoplasmic reticulum (ER) stress, regulates the expression of factors that restore protein folding homeostasis. However, in the liver and kidney, ER stress also leads to lipid accumulation, accompanied

Externí odkaz: https://doaj.org/article/06fe11739d5947738019a2ca0c310e7e

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A beneficial adaptive role for CHOP in driving cell fate selection during ER stress

Autor: Kaihua Liu, Chaoxian Zhao, D. Thomas Rutkowski

Publikováno v: bioRxiv

Cellular stresses elicit signaling cascades that are capable of both mitigating the inciting dysfunction and initiating cell death when the stress cannot be overcome. During endoplasmic reticulum (ER) stress, the transcription factor CHOP is widely r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6256b3ab826a9227c18227927aaa5e
https://europepmc.org/articles/PMC10055232/

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Interference with the HNF4-dependent gene regulatory network diminishes ER stress in hepatocytes

Autor: Anit Shah, Ian Huck, Kaylia Duncan, Erica R. Gansemer, Udayan Apte, Mark A. Stamnes, D. Thomas Rutkowski

Publikováno v: bioRxiv

In all eukaryotic cell types, the unfolded protein response (UPR) upregulates factors that promote protein folding and misfolded protein clearance to help alleviate endoplasmic reticulum (ER) stress. Yet ER stress in the liver is uniquely accompanied

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bcf04abed3696da0817e349b47200b3
https://doi.org/10.1101/2023.02.09.527889

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Akademický článek

Experimental reconstitution of chronic ER stress in the liver reveals feedback suppression of BiP mRNA expression

Autor: Javier A Gomez, D Thomas Rutkowski

Publikováno v: eLife, Vol 5 (2016)

Endoplasmic reticulum (ER) stress is implicated in many chronic diseases, but very little is known about how the unfolded protein response (UPR) responds to persistent ER stress in vivo. Here, we experimentally reconstituted chronic ER stress in the

Externí odkaz: https://doaj.org/article/3e2ae8e91a2542eea34c931282ed71c5

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Akademický článek

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Akademický článek

piggyBac-mediated phenotypic correction of factor VIII deficiency

Autor: Janice M Staber, Molly J Pollpeter, Angela Arensdorf, Patrick L Sinn, D Thomas Rutkowski, Paul B McCray, Jr

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)

Hemophilia A, caused by a deficiency in factor VIII (FVIII), is the most severe inherited bleeding disorder. Hemophilia A is an attractive gene therapy candidate because even small increases in FVIII levels will positively alter the phenotype. While

Externí odkaz: https://doaj.org/article/8a13042e6ecb4028aa741177a9c51d67

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Akademický článek

Temporal clustering of gene expression links the metabolic transcription factor HNF4α to the ER stress-dependent gene regulatory network

Autor: Angela M Arensdorf, Diane eDeZwaan McCabe, Randal J Kaufman, D Thomas Rutkowski

Publikováno v: Frontiers in Genetics, Vol 4 (2013)

The unfolded protein response (UPR) responds to disruption of endoplasmic reticulum (ER) function by initiating signaling cascades that ultimately culminate in extensive transcriptional regulation. Classically, this regulation includes genes encoding

Externí odkaz: https://doaj.org/article/879aa4ac819e4f74888ecc6514d44c27

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Akademický článek

The stress-regulated transcription factor CHOP promotes hepatic inflammatory gene expression, fibrosis, and oncogenesis.

Autor: Diane DeZwaan-McCabe, Jesse D Riordan, Angela M Arensdorf, Michael S Icardi, Adam J Dupuy, D Thomas Rutkowski

Publikováno v: PLoS Genetics, Vol 9, Iss 12, p e1003937 (2013)

Viral hepatitis, obesity, and alcoholism all represent major risk factors for hepatocellular carcinoma (HCC). Although these conditions also lead to integrated stress response (ISR) or unfolded protein response (UPR) activation, the extent to which t

Externí odkaz: https://doaj.org/article/607b8f25d76e47069dd9b7ccf42ab584

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