Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Thomas Riffelmacher"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Externí odkaz:
https://doaj.org/article/fc40d4bacaf444a590fa50ac1bc05224
Autor:
Daniel A. Giles, Sonja Zahner, Petra Krause, Esmé Van Der Gracht, Thomas Riffelmacher, Venetia Morris, Alexei Tumanov, Mitchell Kronenberg
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Over 1.5 million individuals in the United States are afflicted with inflammatory bowel disease (IBD). While the progression of IBD is multifactorial, chronic, unresolved inflammation certainly plays a key role. Additionally, while multiple immune me
Externí odkaz:
https://doaj.org/article/c23cc09191ea4327ba619b3a9a4542e2
Autor:
Agnieszka M Kabat, Oliver J Harrison, Thomas Riffelmacher, Amin E Moghaddam, Claire F Pearson, Adam Laing, Lucie Abeler-Dörner, Simon P Forman, Richard K Grencis, Quentin Sattentau, Anna Katharina Simon, Johanna Pott, Kevin J Maloy
Publikováno v:
eLife, Vol 5 (2016)
A polymorphism in the autophagy gene Atg16l1 is associated with susceptibility to inflammatory bowel disease (IBD); however, it remains unclear how autophagy contributes to intestinal immune homeostasis. Here, we demonstrate that autophagy is essenti
Externí odkaz:
https://doaj.org/article/863f9a4eda8b4447a0c8dfc0ac64807c
Autor:
Thomas Riffelmacher, Mallory Paynich Murray, Chantal Wientjens, Shilpi Chandra, Viankail Cedillo-Castelán, Ting-Fang Chou, Sara McArdle, Christopher Dillingham, Jordan Devereaux, Aaron Nilsen, Simon Brunel, David M. Lewinsohn, Jeff Hasty, Gregory Seumois, Christopher A. Benedict, Pandurangan Vijayanand, Mitchell Kronenberg
Publikováno v:
Nature Cell Biology.
Although mucosal-associated invariant T (MAIT) cells provide rapid, innate-like responses, they are not pre-set, and memory-like responses have been described for MAIT cells following infections. The importance of metabolism for controlling these res
Autor:
Dennis Wolf, Pandurangan Vijayanand, Marco Orecchioni, Nicolas Thiault, Grégory Seumois, Sara Herrera-de la Mata, Yanal Ghosheh, Mitchell Kronenberg, William B. Kiosses, Erik Ehinger, Klaus Ley, Kouji Kobiyama, Vasantika Suryawanshi, Paola Marchovecchio, Holger Winkels, Thomas Riffelmacher
Publikováno v:
J Immunol
Double-positive CD4+CD8αβ+ (DP) cells are thought to reside as T cell progenitors exclusively within the thymus. We recently discovered an unexpected CD4+ and CD8αβ+ immune cell population in healthy and atherosclerotic mice by single-cell RNA se
Autor:
Esmé T I van der Gracht, Alexander Y. Andreyev, Daniel A. Giles, Mallory Paynich Murray, Martina Dicker, Alexei V. Tumanov, Thomas Riffelmacher, Mitchell Kronenberg, Tamara Perez-Jeldres, Sara McArdle, Nadine Hartmann, Sonja Zahner
Publikováno v:
Mucosal Immunology
Inflammatory bowel disease is characterized by an exacerbated intestinal immune response, but the critical mechanisms regulating immune activation remain incompletely understood. We previously reported that the TNF-superfamily molecule TNFSF14 (LIGHT
Autor:
Shilpi Chandra, Gabriel Ascui, Thomas Riffelmacher, Ashu Chawla, Ciro Ramirez-Suastegui, Viankail Cedillo Castelan, Gregory Seumois, Hayley Simon, Mallory Paynich Murray, Goo-Young Seo, Ashmitaa Logandha Ramamoorthy Premlal, Greet Verstichel, Yingcong Li, Chia-Hao Lin, Jason Greenbaum, John Lamberti, Raghav Murthy, John Nigro, Hilde Cheroutre, Christian H. Ottensmeier, Stephen M. Hedrick, Li-Fan Lu, Pandurangan Vijayanand, Mitchell Kronenberg
Mucosal-associated invariant T (MAIT) cells are a subpopulation of T lymphocytes that respond to microbial metabolites. We performed single-cell RNA sequencing and metabolic analyses of MAIT cell subsets in thymus and peripheral tissues from mice and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc0cfdc0713c6e65102b13d2dc0e0788
https://doi.org/10.1101/2021.12.20.473182
https://doi.org/10.1101/2021.12.20.473182
Autor:
Thomas Riffelmacher, Mallory Murray Paynich, Shilpi Chandra, Chantal Wientjens, Gregory Seumois, Pandurangan Vijayanand, Mitchell Kronenberg
Publikováno v:
The Journal of Immunology. 208:55.10-55.10
Mucosal-associated-invariant-T (MAIT) cells are an innate-like T cell subset that recognizes microbial-derived vitamin B metabolites. In contrast to conventional T cells, MAIT cells have an antigen-experienced phenotype and express memory markers by
Publikováno v:
Crit Rev Immunol
Ample evidence exists for activation of invariant natural killer T (iNKT) cells in a sterile manner by endogenous ligands or microbial antigens from the commensal flora, indicating that iNKT cells are not truly self-tolerant. Their controlled autorea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9859a32f8fcf347951868f4ec8cd1b
https://doi.org/10.1615/critrevimmunol.2020035158
https://doi.org/10.1615/critrevimmunol.2020035158
Publikováno v:
Autophagy
The role of macroautophagy/autophagy, a conserved lysosomal degradation pathway, during cellular differentiation has been well studied over the last decade. In particular, evidence for its role during immune cell differentiation is growing. Despite t