Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Thomas R. Verhoeven"'
Autor:
Michel Journet, David L. Hughes, Robert D. Larsen, Thomas R. Verhoeven, Dongwei Cai, Paul J. Reider, Lisa DiMichele
Publikováno v:
The Journal of Organic Chemistry. 64:2411-2417
Compound 1 is a macrocyclic lipopeptide belonging to the echinocandin family, which has been effective in treating systemic fungal infections. In this paper, we report a unique regio-, chemo-, and stereoselective synthesis of 1 in four steps from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c24feef2d818ccc67c158a706098fbaf
https://doi.org/10.1021/jo9822232
https://doi.org/10.1021/jo9822232
Publikováno v:
Tetrahedron Letters. 39:3961-3964
An efficient enantioselective synthesis of L-784,512 featuring a Horner-Emmons reaction, a new one-pot trifluoromethylation, and the Sharpless asymmetric dihydroxylation is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87ff68e71afb4087010d418cb727d74d
https://doi.org/10.1016/s0040-4039(98)00735-7
https://doi.org/10.1016/s0040-4039(98)00735-7
Autor:
Lisa DiMichele, Raymond Cvetovich, Richard F. Shuman, Timothy J. Bill, Thomas R. Verhoeven, Edward J. J. Grabowski, Joseph S. Amato, Chris H. Senanayake, Robert D. Larsen
Publikováno v:
The Journal of Organic Chemistry. 62:3989-3993
Practical high yielding syntheses of 13-O-[(2-methoxyethoxy)methyl]-22,23-dihydroavermectin B1 aglycon (dimedectin 2-propanol, MK-324, 1) and 13-epi-O-(methoxymethyl)-22,23-dihydroavermectin B1 aglycon (L-694,554, 2), both potent flea insecticides, f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1548919053c2e99ca05564ad88f5789
https://doi.org/10.1021/jo970187l
https://doi.org/10.1021/jo970187l
Publikováno v:
Tetrahedron Letters. 38:2641-2644
A convenient and economical in situ preparation of DIP-Chloride tm from NaBH4, BCl3 and α-pinene is described. Its application in the asymmetric reduction of representative aralkyl ketones is presented.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6c7e9c07e91c46d279c54fecc1db32e
https://doi.org/10.1016/s0040-4039(97)00440-1
https://doi.org/10.1016/s0040-4039(97)00440-1
Autor:
Linda Gerena, Thomas R. Verhoeven, Dongwei Cai, Paul J. Reider, Ian W. Davies, Robert D. Larsen
Publikováno v:
Tetrahedron Letters. 38:1145-1148
A toolbox of bis(oxazoline) and pyridinebis(oxazoline) ligands 6, 7, 8 has been used to probe conformational effects in Cu(II)-catalyzed Diels-Alder and Ru(II)-catalyzed cyclopropanation reactions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d84224ae0c94ed072cb6a2ed13f19c2
https://doi.org/10.1016/s0040-4039(97)00010-5
https://doi.org/10.1016/s0040-4039(97)00010-5
Autor:
Ji Liu, Paul J. Reider, Richard G. Ball, Thomas R. Verhoeven, Lisa DiMichele, Pascal H. Toma, Robert D. Larsen, Chris H. Senanayake
Publikováno v:
Tetrahedron: Asymmetry. 7:1501-1506
A regio- and stereo-controlled synthesis of chiral cis-1-amino-1-phenylcyclohexan-2-ol is described. The optically pure diol 4 was converted to the ligand 8 in 80% yield.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd4693023a4754be2e2313e3af0b73d1
https://doi.org/10.1016/0957-4166(96)00169-3
https://doi.org/10.1016/0957-4166(96)00169-3
Autor:
Paul J. Reider, Kenneth M. Ryan, F. Edward Roberts, Laura E. Fredenburgh, Ji Liu, David L. Hughes, Chris H. Senanayake, George B. Smith, Robert D. Larsen, Thomas R. Verhoeven
Publikováno v:
Tetrahedron Letters. 37:3271-3274
4-(3-Phenylpropyl)pyridine N-Oxide (P 3 NO) has provided a more active and stable catalytic media for manganese-salen complex 1 in the asymmetric epoxidation of indene.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49bcfc0da774db05123a08787c216d0e
https://doi.org/10.1016/0040-4039(96)00565-5
https://doi.org/10.1016/0040-4039(96)00565-5
Autor:
Cheng-yi Chen, Thomas R. Verhoeven, David R. Lieberman, Robert D. Larsen, Leslie J. Street, Alexander Richard Guiblin
Publikováno v:
Synthetic Communications. 26:1977-1984
A palladium-catalyzed coupling of iodoaniline 2 with bis-TES propargyl alcohol 3 gives indole-3-methanol 4b in 72% yield. Displacement of the hydroxy group of 4b by sodium cyanide followed by hydrolysis of the cyano group and desilylation provides th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a81f4ea7fe968a0cf6f7dbf4f0f998b8
https://doi.org/10.1080/00397919608003552
https://doi.org/10.1080/00397919608003552
Publikováno v:
Tetrahedron Letters. 37:2537-2540
Mono-lithiation of 2,6-dibromopyridine by n-BuLi is complicated by deprotonation of the pyridine ring by the resulting mono-lithium species. This problem can be eliminated by a reverse addition, but this causes formation of the undesired dilithio spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70485009bf8c109c001ab329633e5490
https://doi.org/10.1016/0040-4039(96)00336-x
https://doi.org/10.1016/0040-4039(96)00336-x
Publikováno v:
Organometallics. 15:663-667
Olefination of esters using dimethyltitanocene is proposed to proceed via the titanium carbene, Cp2TiCH2, on the basis of the following evidence: (1) No H/D exchange or 13C scrambling occurs in the reactions of ethyl acetate or dodecyl acetate using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd6acdeda8986ec3a6131f10f518a28e
https://doi.org/10.1021/om9507843
https://doi.org/10.1021/om9507843