Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Thomas R. Sokolowski"'
Autor:
Thomas R. Sokolowski
Publikováno v:
Cell systems. 13(7)
For a long time, application of information theory for characterizing biological signaling fidelity was limited to "telegraph-like" situations, copying the classical scenario for which it was developed. A study published in this issue of Cell Systems
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c973168d5ea0402312b184bfeacf79
https://pubmed.ncbi.nlm.nih.gov/35863325
https://pubmed.ncbi.nlm.nih.gov/35863325
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 8, p e1002654 (2012)
Embryonic development is driven by spatial patterns of gene expression that determine the fate of each cell in the embryo. While gene expression is often highly erratic, embryonic development is usually exceedingly precise. In particular, gene expres
Externí odkaz:
https://doaj.org/article/37d7bb2843ed4cc787ab4a2eaf8067e6
Publikováno v:
Neuron. 109:1227-1241.e5
Normative theories and statistical inference provide complementary approaches for the study of biological systems. A normative theory postulates that organisms have adapted to efficiently solve essential tasks, and proceeds to mathematically work out
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3068b00ab0908cd8a3693419da6a67e1
https://doi.org/10.1016/j.neuron.2021.01.020
https://doi.org/10.1016/j.neuron.2021.01.020
Autor:
Nils B. Becker, Kazunari Kaizu, Marileen Dogterom, Joris Paijmans, Thomas Miedema, Laurens Bossen, Pieter Rein ten Wolde, Koichi Takahashi, Thomas R. Sokolowski, Martijn Wehrens
Publikováno v:
Journal of Chemical Physics
Biochemical reactions typically occur at low copy numbers, but at once in crowded and diverse environments. Space and stochasticity therefore play an essential role in biochemical networks. Spatial-stochastic simulations have become a prominent tool
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73b2c008f9cf9182fb7fc00116d66ef
Publikováno v:
Physical Review E. 93
A crucial step in the regulation of gene expression is binding of transcription factor (TF) proteins to regulatory sites along the DNA. But transcription factors act at nanomolar concentrations, and noise due to random arrival of these molecules at t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf01b699eb3cbb85d22802665ee6c465
https://doi.org/10.1103/physreve.93.022404
https://doi.org/10.1103/physreve.93.022404
Autor:
Aristea Grammoustianou, Thomas R. Sokolowski, Pierre Recouvreux, Pieter Rein ten Wolde, Marileen Dogterom
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 113(7)
Cell polarity refers to a functional spatial organization of proteins that is crucial for the control of essential cellular processes such as growth and division. To establish polarity, cells rely on elaborate regulation networks that control the dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f73daa3a55b014accbd48ba2db57adfe
http://resolver.tudelft.nl/uuid:038b77d2-6793-4dfa-8ca7-6f733f0b4f96
http://resolver.tudelft.nl/uuid:038b77d2-6793-4dfa-8ca7-6f733f0b4f96
Autor:
Thomas R. Sokolowski, Gašper Tkačik
We typically think of cells as responding to external signals independently by regulating their gene expression levels, yet they often locally exchange information and coordinate. Can such spatial coupling be of benefit for conveying signals subject
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e347dc4f0667991972c43031c09972
http://arxiv.org/abs/1501.04015
http://arxiv.org/abs/1501.04015
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 8, Iss 8, p e1002654 (2012)
PLoS Computational Biology, Vol 8, Iss 8, p e1002654 (2012)
Embryonic development is driven by spatial patterns of gene expression that determine the fate of each cell in the embryo. While gene expression is often highly erratic, embryonic development is usually exceedingly precise. In particular, gene expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f78e21cc515957600dd436cc8b4bbbd
http://europepmc.org/articles/PMC3431325
http://europepmc.org/articles/PMC3431325
Autor:
Thomas R. Sokolowski, C F Moukarzel
Publikováno v:
Journal of Physics: Conference Series. 246:012019
Bootstrap (or k-core) Percolation with k = 3 is studied numerically on two-dimensional lattices with long-range links whose lengths rij are distributed according to P(r) ~ r−α. By varying the decay exponent α the topology of these networks can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59383ac09cd77ce5c280f469cf9bed16
https://doi.org/10.1088/1742-6596/246/1/012019
https://doi.org/10.1088/1742-6596/246/1/012019
Publikováno v:
2019 IEEE Information Theory Workshop (ITW)
ITW
ITW
We derive a tight lower bound on equivocation (conditional entropy), or equivalently a tight upper bound on mutual information between a signal variable and channel outputs. The bound is in terms of the joint distribution of the signals and maximum a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda37d7f7e6391a23079500d0f9beb36