Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Thomas R. Silvers"'
Autor:
John A. Martignetti, Peter Dottino, Morten Mau-Sørensen, Mansoor R. Mirza, Michael Kauffman, Tami Rashal, Yosef Landesman, Dilara McCauley, Sharon Shacham, Jean-Noel Billaud, Richard Halpert, Rileen Sinha, Rong Chen, Andrew Uzilov, Robert Sebra, Tamara Kalir, Faisal Khan, Michael Donovan, Estefania Rodriguez, Nolan Priedigkeit, Fei Huang, Susan J. Ramus, Brad R. Evans, Elena Pereira, Eva Kalir, John F. Gerecitano, Nashat Y. Gabrail, Albiruni R.A. Razak, Thomas R. Silvers, Sandra Catalina Camacho, Ying Chen
Supplementary Material and Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd94388a9ace123fadf893e903e3182
https://doi.org/10.1158/1078-0432.22464165.v1
https://doi.org/10.1158/1078-0432.22464165.v1
Autor:
John A. Martignetti, Peter Dottino, Morten Mau-Sørensen, Mansoor R. Mirza, Michael Kauffman, Tami Rashal, Yosef Landesman, Dilara McCauley, Sharon Shacham, Jean-Noel Billaud, Richard Halpert, Rileen Sinha, Rong Chen, Andrew Uzilov, Robert Sebra, Tamara Kalir, Faisal Khan, Michael Donovan, Estefania Rodriguez, Nolan Priedigkeit, Fei Huang, Susan J. Ramus, Brad R. Evans, Elena Pereira, Eva Kalir, John F. Gerecitano, Nashat Y. Gabrail, Albiruni R.A. Razak, Thomas R. Silvers, Sandra Catalina Camacho, Ying Chen
Supplementary Figure 1. Overview of XPO1's role in nuclear:cytoplasmic transport. Supplementary Figure 2. KPT-185 is much less toxic to patient-derived benign cells than patient-derived serous high grade OvCa cells. Supplementary Figure 3. FACS cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bda5ace0e09d7253667d7c8ae0026f8
https://doi.org/10.1158/1078-0432.22464168
https://doi.org/10.1158/1078-0432.22464168
Autor:
John A. Martignetti, Peter Dottino, Morten Mau-Sørensen, Mansoor R. Mirza, Michael Kauffman, Tami Rashal, Yosef Landesman, Dilara McCauley, Sharon Shacham, Jean-Noel Billaud, Richard Halpert, Rileen Sinha, Rong Chen, Andrew Uzilov, Robert Sebra, Tamara Kalir, Faisal Khan, Michael Donovan, Estefania Rodriguez, Nolan Priedigkeit, Fei Huang, Susan J. Ramus, Brad R. Evans, Elena Pereira, Eva Kalir, John F. Gerecitano, Nashat Y. Gabrail, Albiruni R.A. Razak, Thomas R. Silvers, Sandra Catalina Camacho, Ying Chen
Purpose: The high fatality-to-case ratio of ovarian cancer is directly related to platinum resistance. Exportin-1 (XPO1) is a nuclear exporter that mediates nuclear export of multiple tumor suppressors. We investigated possible clinicopathologic corr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0145a7f4193fe36b646da6771fbef93b
https://doi.org/10.1158/1078-0432.c.6525636.v1
https://doi.org/10.1158/1078-0432.c.6525636.v1
Autor:
John A. Martignetti, Peter Dottino, Morten Mau-Sørensen, Mansoor R. Mirza, Michael Kauffman, Tami Rashal, Yosef Landesman, Dilara McCauley, Sharon Shacham, Jean-Noel Billaud, Richard Halpert, Rileen Sinha, Rong Chen, Andrew Uzilov, Robert Sebra, Tamara Kalir, Faisal Khan, Michael Donovan, Estefania Rodriguez, Nolan Priedigkeit, Fei Huang, Susan J. Ramus, Brad R. Evans, Elena Pereira, Eva Kalir, John F. Gerecitano, Nashat Y. Gabrail, Albiruni R.A. Razak, Thomas R. Silvers, Sandra Catalina Camacho, Ying Chen
Supplementary Figure Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37be2227d7e7d5b4425f5fb0ff89b03d
https://doi.org/10.1158/1078-0432.22464174.v1
https://doi.org/10.1158/1078-0432.22464174.v1
Autor:
John A. Martignetti, Peter Dottino, Morten Mau-Sørensen, Mansoor R. Mirza, Michael Kauffman, Tami Rashal, Yosef Landesman, Dilara McCauley, Sharon Shacham, Jean-Noel Billaud, Richard Halpert, Rileen Sinha, Rong Chen, Andrew Uzilov, Robert Sebra, Tamara Kalir, Faisal Khan, Michael Donovan, Estefania Rodriguez, Nolan Priedigkeit, Fei Huang, Susan J. Ramus, Brad R. Evans, Elena Pereira, Eva Kalir, John F. Gerecitano, Nashat Y. Gabrail, Albiruni R.A. Razak, Thomas R. Silvers, Sandra Catalina Camacho, Ying Chen
Supplementary Table 1. cBIO data for XPO1 overexpression and association with survival. Supplementary Table 2. Clinical features of patient samples in TMA. Supplementary Table 3. Clinicopathologic features for patient-derived tumor cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bda1421f88aa036542b3c59734051f3
https://doi.org/10.1158/1078-0432.22464162.v1
https://doi.org/10.1158/1078-0432.22464162.v1
Autor:
Rebecca Zabinsky, Jonathan Mares, Richard She, Michelle Zeman, Audrey Chang, James Talbot, Edgar A. Campbell, Tina Monzavi, Thomas R. Silvers, Daniel F. Jarosz
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::981ecf7b5f72ea830ff9ae3e007ed025
https://doi.org/10.2139/ssrn.4136719
https://doi.org/10.2139/ssrn.4136719
Autor:
Russell Reinhart, Julie Laudeman, Chad Ogle, Thomas S. Dexheimer, Thomas R. Silvers, Beverly A. Teicher, Nathan P. Coussens, Rene Delosh, John J. Wright, James H. Doroshow
Publikováno v:
Cancer Research. 81:1028-1028
KRAS is one of the most frequently mutated oncogenes in cancer and efforts to directly target KRAS have been challenging. However, covalent inhibitors targeting a specific KRASG12C (Gly12 to Cys12) variant have recently been developed and have demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a19b4a70b547cc8d7d98606706ef5972
https://doi.org/10.1158/1538-7445.am2021-1028
https://doi.org/10.1158/1538-7445.am2021-1028
Autor:
Thomas R. Silvers, John A. Martignetti, Sandra Catalina Camacho, Rileen Sinha, Morten Mau-Sørensen, Elena Pereira, Susan J. Ramus, Eva Kalir, Tamara Kalir, Mansoor Raza Mirza, Tami Rashal, Yosef Landesman, Estefanía Rodríguez, Nashat Y. Gabrail, Richard Halpert, Peter Dottino, John F. Gerecitano, Andrew V. Uzilov, Robert Sebra, Faisal Khan, Rong Chen, Albiruni Ryan Abdul Razak, Ying Chen, Jean-Noel Billaud, Michael Kauffman, Sharon Shacham, Brad R. Evans, Nolan Priedigkeit, Michael J. Donovan, Dilara McCauley, Fei Huang
Publikováno v:
Clinical Cancer Research. 23:1552-1563
Purpose: The high fatality-to-case ratio of ovarian cancer is directly related to platinum resistance. Exportin-1 (XPO1) is a nuclear exporter that mediates nuclear export of multiple tumor suppressors. We investigated possible clinicopathologic corr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11342ab6623cdc794d0f89f853422720
https://doi.org/10.1158/1078-0432.ccr-16-1333
https://doi.org/10.1158/1078-0432.ccr-16-1333
Autor:
Daniel F. Jarosz, Richard She, Rebecca Ann Zabinsky, Michelle K. Zeman, Jonathan Mares, Thomas R. Silvers
Rapid mutation fuels the evolution of many cancers and pathogens. Much of the ensuing genetic variation is detrimental, but cells can survive by limiting the cost of accumulating mutation burden. We investigated this behavior by propagating hypermuta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16068f0e1ccf3bfb0b6d73cf1fb6c1a3
Autor:
Robert Sebra, John A. Martignetti, Ying-Chih Wang, Bozinovic Nenad, Hanane Arib, Wissam Hamou, Ethan Ellis, Hardik Shah, Peter Dottino, Kimaada Allette, Eric E. Schadt, Thomas R. Silvers, Maya Strahl, Kristin G. Beaumont, Melissa Smith, Mark A. White, Bruhn Brandon R, Arpit Dave, Alesia Antoine
Genetic and functional complexity of bulk tumor has become evident through rapid advances in sequencing technologies. As a unique integrated approach to characterizing tumor heterogeneity, we demonstrate the multifaceted capabilities of a novel nanof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0345bacf4a3dc717ec3fdddde7abcd53
https://doi.org/10.1101/457010
https://doi.org/10.1101/457010