Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Thomas R. Podleski"'
Autor:
Thomas R. Podleski, Joyce A.M. Wootton, Ora Horovitz, Miriam M. Salpeter, Enchi Liu, Ronald R. Minor
Publikováno v:
Experimental cell research. 209(1)
Previous studies have shown that ascorbic acid increases both the total surface acetylcholine receptor (AChR) expression and the mRNA for the alpha-subunit of this receptor in myotubes of cloned L5 muscle cultures. Since ascorbic acid increases colla
Publikováno v:
The American journal of clinical nutrition. 54
Ascorbic acid is the active component of fetal brain extract that induces increased acetylcholine receptor (AChR) expression in L5 rat clonal muscle cell cultures. The induction of AChR expression, as determined by 125I-alpha-bungarotoxin binding, oc
Autor:
Antonio Sastre, Thomas R. Podleski
Publikováno v:
Proceedings of the National Academy of Sciences. 73:1355-1359
We present a pharmacologic characterization of the Na+ ionophores present in L6 myotubes in vitro. Action potentials are abolished by replacement of the external Na+ by Tris. The amplitude of the action potential is generally resistant to high concen
Publikováno v:
Annals of the New York Academy of Sciences. 498:77-89
Publikováno v:
The Journal of Cell Biology
Ascorbic acid in soluble extracts of neural tissue can account for the increase in surface acetyl- choline receptors (AChR's) seen on L5 myogenic cells treated with crude brain extract (Knaack, D., and T. R. Podleski, 1985, Proc. Natl. Acad. Sci. USA
Publikováno v:
The Journal of Physiology. 269:155-176
1. A linear relation, with a slope of 0-9 +/- 0-2 on a log-log plot, was obtained between acetylcholine (ACh) sensitivity and alpha-bungarotoxin (alpha-BTX) binding site density in developing L6 and rat primary myotubes. ACh sensitivity was defined a
Publikováno v:
The Journal of Cell Biology
Ascorbic acid is the major factor in brain extract responsible for increasing the average acetylcholine receptor (AChR) site density on the cloned muscle cell line L5. In the present study, we show that this effect of ascorbic acid requires mRNA synt
Publikováno v:
Journal of Neurobiology. 7:537-549
SUMMARY The electrophysiological properties of a tissue culture muscle line, L6, and a K+ resistant mutant (MKI) derived from LG were determined to elucidate certain aspects of membrane differentiation and function. MKI was selected as a clone of myo
Publikováno v:
The Journal of Comparative Neurology. 274:255-264
We have localized nicotinic acetylcholine receptors in the zebra finch brain by using three 125I-labelled ligands: alpha bungarotoxin and two monoclonal antibodies to neuronal nicotinic receptors (MAb 35 of Tzardos et al., J. Biol. Chem., 250: 8635-8
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 511:23-38
The molecular control of the distribution and motion of acetylcholine receptors in the plasma membrane of developing rat myotubes in primary cell culture was investigated by fluorescence techniques. Acetylcholine receptors were marked with tetramethy