Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Thomas R. Laws"'
Autor:
Bevelynn Williams, Jamie Paterson, Helena J. Rawsthorne-Manning, Polly-Anne Jeffrey, Joseph J. Gillard, Grant Lythe, Thomas R. Laws, Martín López-García
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Protective antigen (PA) is a protein produced by Bacillus anthracis. It forms part of the anthrax toxin and is a key immunogen in US and UK anthrax vaccines. In this study, we have conducted experiments to quantify PA in the supernatants of
Externí odkaz:
https://doaj.org/article/7c505df9ca3247c2994f287c4d5b88ec
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Animal models of infectious disease often serve a crucial purpose in obtaining licensure of therapeutics and medical countermeasures, particularly in situations where human trials are not feasible, i.e., for those diseases that occur infrequently in
Externí odkaz:
https://doaj.org/article/29eca1c3099b4f5bbd2e64f8a0fdc384
Autor:
Fatih Buyuk, Hugh Dyson, Thomas R. Laws, Ozgur Celebi, Mehmet Doganay, Mitat Sahin, Les Baillie
Publikováno v:
Microorganisms, Vol 12, Iss 1, p 167 (2024)
Environmental contamination with Bacillus anthracis spores poses uncertain threats to human health. We undertook a study to determine whether inhabitants of the anthrax-endemic region of Kars in eastern Türkiye could develop immune responses to anth
Externí odkaz:
https://doaj.org/article/bb873c2ff13941a6b1d442e043e6401d
Autor:
Kay B. Barnes, Marc Bayliss, Carwyn Davies, Mark I. Richards, Thomas R. Laws, Andreas Vente, Sarah V. Harding
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Burkholderia mallei, the causative agent of glanders, is principally a disease of equines, although it can also infect humans and is categorized by the U.S. Centers for Disease Control and Prevention as a category B biological agent. Human cases of g
Externí odkaz:
https://doaj.org/article/65b439ec2bce445b839620f425b81232
Autor:
Thomas R. Laws, Thomas C. Maishman
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Ethical research with experimental systems (animals or humans) requires a rationale for the number of subjects to be included in a study. Standard methods for estimating sample size are not fit-for-purpose when the experimenter cannot predict the eff
Externí odkaz:
https://doaj.org/article/08c65e70375c45b59b75363c021bb398
Autor:
Kay B. Barnes, Mark I. Richards, Gary Burgess, Stuart J. Armstrong, Christine Bentley, Thomas C. Maishman, Thomas R. Laws, Michelle Nelson, Sarah V. Harding
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The efficacy of finafloxacin as a component of a layered defense treatment regimen was determined in vitro and in vivo against an infection with Burkholderia pseudomallei. Doxycycline was down-selected from a panel of antibiotics evaluated in vitro a
Externí odkaz:
https://doaj.org/article/e6706cff0d9d4c09827642bcea38ae7d
Autor:
Amanda L. Phelps, Francisco J. Salguero, Laura Hunter, Alexander L. Stoll, Dominic C. Jenner, Lyn M. O’Brien, E. Diane Williamson, M. Stephen Lever, Thomas R. Laws
Publikováno v:
Viruses, Vol 15, Iss 6, p 1307 (2023)
Venezuelan equine encephalitis virus (VEEV) is a disease typically confined to South and Central America, whereby human disease is characterised by a transient systemic infection and occasionally severe encephalitis, which is associated with lethalit
Externí odkaz:
https://doaj.org/article/e70fd92fe4514860a2fa2333c1032872
Autor:
Bevelynn Williams, Martín López-García, Joseph J. Gillard, Thomas R. Laws, Grant Lythe, Jonathan Carruthers, Thomas Finnie, Carmen Molina-París
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
We present a stochastic mathematical model of the intracellular infection dynamics of Bacillus anthracis in macrophages. Following inhalation of B. anthracis spores, these are ingested by alveolar phagocytes. Ingested spores then begin to germinate a
Externí odkaz:
https://doaj.org/article/d1f4df906d3c41edb779c00ba540361b
Autor:
Thomas R. Laws, Kay B. Barnes, Dominic C. Jenner, Alejandro Núñez, Mark I. Richards, Joanne E. Thwaite, Andreas Vente, David Rushton, Michelle Nelson, Sarah V. Harding
Publikováno v:
Antibiotics, Vol 11, Iss 10, p 1442 (2022)
Burkholderia pseudomallei is the causative agent of melioidosis, a multifaceted disease. A proportion of the mortality and morbidity reported as a result of infection with this organism may be due to the premature cessation of antibiotic therapy typi
Externí odkaz:
https://doaj.org/article/36d0b3fd7c504de8a03a4d84ca53a73a
Autor:
Sophie J. Smither, Sarah Kempster, Simon L. Priestnall, Alejandro Suárez-Bonnet, Helen Stapleton, Thomas R. Laws, Deborah Ferguson, Neil Almond, Mark S. Lever, E. Diane Williamson
Publikováno v:
Viruses, Vol 14, Iss 8, p 1769 (2022)
A transduced mouse model of SARS-CoV-2 infection was established using Balb/c mice. This was achieved through the adenovirus-vectored delivery of the hACE2 gene, to render the mice transiently susceptible to the virus. The model was characterised in
Externí odkaz:
https://doaj.org/article/1c19343f8b1646ec9cc9838b0f77d932