Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Thomas R. Downs"'
Autor:
Stefan Pfuhler, Thomas R Downs, Nicola J Hewitt, Sebastian Hoffmann, Greg C Mun, Gladys Ouedraogo, Shambhu Roy, Rodger D Curren, Marilyn J Aardema
Publikováno v:
Mutagenesis
In vitro test batteries have become the standard approach to determine the genotoxic potential of substances of interest across industry sectors. While useful for hazard identification, standard in vitro genotoxicity assays in 2D cell cultures have l
Autor:
Monika Schäfer-Korting, Marion Merkel, Claudia Petrick, Ralph Pirow, Kerstin Reisinger, Andrea Haase, Nicola J. Hewitt, Andreas Luch, Thomas R. Downs, André Said, Stefan Pfuhler
Publikováno v:
Mutagenesis
As part of the safety assessment process, all industrial sectors employ genotoxicity test batteries, starting with well-established in vitro assays. However, these batteries have limited predictive capacity for the in vivo situation, which may result
Publikováno v:
Mutagenesis
In vitro genotoxicity assays utilising human skin models are becoming important tools for the safety assessment of chemicals whose primary exposure is via the dermal route. In order to explore metabolic competency and inducibility of CYP450 activatin
Autor:
V. Blatz, Frank Henkler, Kerstin Reisinger, Stefan Pfuhler, Astrid A. Reus, Anja Fischer, Cyrille Krul, Sebastian Hoffmann, Thomas R. Downs, Manfred Liebsch, Markus Schulz, Joep Brinkmann, Andreas Luch, Ralph Pirow
Publikováno v:
Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 827, 27-41
Recently revised OECD Testing Guidelines highlight the importance of considering the first site-of-contact when investigating the genotoxic hazard. Thus far, only in vivo approaches are available to address the dermal route of exposure. The 3D Skin C
Externí odkaz:
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http://resolver.tudelft.nl/uuid:153766fa-4050-432f-bb78-384547d26059
Publikováno v:
Mutagenesis. 32(1)
In a previous study, 15-nm silica nanoparticles (NPs) caused small increases in DNA damage in liver as measured in the in vivo comet and micronucleus assays after intravenous administration to rats at their maximum tolerated dose, a worst-case exposu
Autor:
Matt Lynch, Thomas R. Downs, Shyam Kumar, Stefan Pfuhler, Meredith E. Crosby, Tim Mills, Matthew Scott Wagner, Ashley Sullivan, Katherine Sarlo, Ting Hu, Bob Reeder
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 745:38-50
While the collection of genotoxicity data and insights into potential mechanisms of action for nano-sized particulate materials (NPs) are steadily increasing, there is great uncertainty whether current standard assays are suitable to appropriately ch
Autor:
William C. de Groat, Brian Joseph Limberg, Debra E. Artim, F. Aura Kullmann, Jan S. Rosenbaum, Mansi Shah, Dan Contract, Thomas R. Downs
Publikováno v:
Neurourology and Urodynamics. 30:144-150
To investigate the distribution of beta-3 adrenergic receptors (β(3)ARs) in the rat bladder and to examine the contribution of urothelial β(3)ARs to agonist-induced suppression of bladder reflexes and relaxation of smooth muscle.Bladder tissue was
Autor:
Karl-Erik Andersson, Jean-Jacques Wyndaele, Kazuyoshi Iijima, Yasuhiko Igawa, Jan S. Rosenbaum, Thomas R. Downs, Naoki Aizawa
Publikováno v:
BJU International. 108:E10-E16
What’s known on the subject? and What does the study add? The effects of oestrogen on lower urinary tract structure and function, and on the autonomic nervous control of the region, have been examined in animal studies, often with conflicting resul
Autor:
Jan S. Rosenbaum, Mansi Shah, Brian Joseph Limberg, John August Wos, F. Aura Kullmann, Debra E. Artim, Thomas R. Downs, Dan Contract, William C. de Groat
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 330:704-717
Voiding dysfunctions, including increased voiding frequency, urgency, or incontinence, are prevalent in the postmenopausal population. Beta(3)-adrenergic receptor (beta(3)AR) agonists, which relax bladder smooth muscle, are being developed to treat t
Autor:
Mushtaq Ahmad, Thomas R. Downs, Edgar P. Heimer, Theodore Lambros, Lawrence A. Frohman, Arthur Felix
Publikováno v:
International Journal of Peptide and Protein Research. 37:552-555
The recently described mouse growth hormone-releasing factor (mGRF) was synthesized by the solid phase procedure, purified by 2 stages of preparative high performance liquid chromatography and fully characterized. The biologic activity of the 42-amin