Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Thomas R. Caulfield"'
Autor:
Yasuteru Inoue, Yingxue Ren, Shuwen Zhang, Michael Bamkole, Naeyma N. Islam, Manikandan Selvaraj, Wenyan Lu, Thomas R. Caulfield, Yonghe Li, Takahisa Kanekiyo
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
The maturation of brain microvascular endothelial cells leads to the formation of a tightly sealed monolayer, known as the blood–brain barrier (BBB). The BBB damage is associated with the pathogenesis of age-related neurodegenerative diseases inclu
Externí odkaz:
https://doaj.org/article/044332bc5f914607b440f788e2c9c05e
Structural and Functional Characterization of the Most Frequent Pathogenic PRKN Substitution p.R275W
Autor:
Bernardo A. Bustillos, Liam T. Cocker, Mathew A. Coban, Caleb A. Weber, Jenny M. Bredenberg, Paige K. Boneski, Joanna Siuda, Jaroslaw Slawek, Andreas Puschmann, Derek P. Narendra, Neill R. Graff-Radford, Zbigniew K. Wszolek, Dennis W. Dickson, Owen A. Ross, Thomas R. Caulfield, Wolfdieter Springer, Fabienne C. Fiesel
Publikováno v:
Cells, Vol 13, Iss 18, p 1540 (2024)
Mutations in the PINK1 and PRKN genes are the most frequent genetic cause of early-onset Parkinson disease. The pathogenic p.R275W substitution in PRKN is the most frequent substitution observed in patients, and thus far has been characterized mostly
Externí odkaz:
https://doaj.org/article/5d6ad57649a348b39690f2d65abfc257
Autor:
Garrett Deletti, Sajan D. Green, Caleb Weber, Kristen N. Patterson, Swapnil S. Joshi, Tushar M. Khopade, Mathew Coban, James Veek-Wilson, Thomas R. Caulfield, Rajesh Viswanathan, Amy L. Lane
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The 2,5-diketopiperazines are a prominent class of bioactive molecules. The nocardioazines are actinomycete natural products that feature a pyrroloindoline diketopiperazine scaffold composed of two D-tryptophan residues functionalized by N-
Externí odkaz:
https://doaj.org/article/0e378fe5aa2f4a71a4bc4a9d3e10d906
Autor:
Hezi Hayun, Matt Coban, Ashok Kumar Bhagat, Eden Ozer, Lital Alfonta, Thomas R. Caulfield, Evette S. Radisky, Niv Papo
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Matrix metalloproteinases (MMPs) regulate the degradation of extracellular matrix (ECM) components in biological processes. MMP activity is controlled by natural tissue inhibitors of metalloproteinases (TIMPs) that non-selectively inhibit th
Externí odkaz:
https://doaj.org/article/9302df7774f5463d897a9547d6d88c2a
Autor:
Prakasha Kempaiah, Claudia R. Libertin, Rohit A. Chitale, Islam Naeyma, Vasili Pleqi, Johnathan M. Sheele, Michelle J. Iandiorio, Almira L. Hoogesteijn, Thomas R. Caulfield, Ariel L. Rivas
Publikováno v:
Biomedicines, Vol 12, Iss 4, p 871 (2024)
Background: While ‘immuno-competence’ is a well-known term, it lacks an operational definition. To address this omission, this study explored whether the temporal and structured data of the complete blood cell count (CBC) can rapidly estimate imm
Externí odkaz:
https://doaj.org/article/2c6e09de39424f9e8d20f46f802d1d41
Autor:
Naeyma N. Islam, Caleb A. Weber, Matt Coban, Liam T. Cocker, Fabienne C. Fiesel, Wolfdieter Springer, Thomas R. Caulfield
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 365 (2024)
Complete loss-of-function mutations in the PRKN gene are a major cause of early-onset Parkinson’s disease (PD). PRKN encodes the Parkin protein, an E3 ubiquitin ligase that works in conjunction with the ubiquitin kinase PINK1 in a distinct quality
Externí odkaz:
https://doaj.org/article/99e78e36cc994780a3be252ae9a5c6cc
Autor:
Yusuke Kojima, Yuka Machida, Sowmiya Palani, Thomas R. Caulfield, Evette S. Radisky, Scott H. Kaufmann, Yuichi J. Machida
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
DNA-protein crosslinks represent obstacles on genomic DNA that can hamper progression of replication forks. Here, the authors reveal that FAM111A, a PCNA-interacting protein, plays part in mitigating the effect of protein obstacles on replication for
Externí odkaz:
https://doaj.org/article/e9822e13f0724bd0b06193f6b527c895
Autor:
Patrick R. Blackburn, Jodi M. Carter, Devin Oglesbee, Jennifer J. Westendorf, Brian A. Neff, Damian Stichel, David W. Tsen, Ralitza H. Gavrilova, Pieter Wesseling, Andreas von Deimling, Thomas R. Caulfield, Eric W. Klee, Stefan Pusch, Carrie Y. Inwards
Publikováno v:
HGG Advances, Vol 1, Iss 1, Pp 100006- (2020)
Summary: Chondrogenic tumors involving the temporal bone are rare and typically arise spontaneously with unilateral presentation. Somatic IDH mutations are common in these tumors, but germline inheritance has not been documented to our knowledge. We
Externí odkaz:
https://doaj.org/article/fd4d8910b07a49f38b62bd636b2281bd
Autor:
John E. Richter Jr., Charitha Vadlamudi, Sarah K. Macklin, Ayesha Samreen, Haytham Helmi, Daniel Broderick, Ahmed N. Mohammad, Stephanie L. Hines, Jay A. VanGerpen, Paldeep S. Atwal, Thomas R. Caulfield
Publikováno v:
Case Reports in Genetics, Vol 2020 (2020)
Background. The ATP-binding cassette, subfamily D, member 1 (ABCD1) protein is a peroxisomal half-transporter that allows for very long chain fatty acid (VLCFA) degradation. Pathogenic variants of ABCD1 cause VLCFAs to build up in various tissues and
Externí odkaz:
https://doaj.org/article/e2976b88cf5e4e80a013a27f5f823bb8
Autor:
Sarah K. Macklin, Katelyn A. Bruno, Charitha Vadlamudi, Haytham Helmi, Ayesha Samreen, Ahmed N. Mohammad, Stephanie Hines, Paldeep S. Atwal, Thomas R. Caulfield
Publikováno v:
Case Reports in Medicine, Vol 2020 (2020)
We describe the phenotype of a patient with extensive aortic, carotid, and abdominal dissections. The proband was found to have a heterozygous deletion of exons 21–34 in MYLK, which is a rare finding, as deletions in this gene have been infrequentl
Externí odkaz:
https://doaj.org/article/0888aed61dc54bf58e1edee6718d328c