Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Thomas R. Blackwell"'
Autor:
Philip J. Kingsley, Thomas R. Blackwell, Lawrence J. Marnett, Ha-Na Shim, James J. Galligan, William D Sanders, Thong Luong, Mark deCaestecker, Jeannie M. Camarillo, William N. Beavers, Orrette R. Wauchope, Michelle M. Mitchener, Joshua P. Fessel
Publikováno v:
Nucleic Acids Research
Reactive oxygen species (ROS) are formed in mitochondria during electron transport and energy generation. Elevated levels of ROS lead to increased amounts of mitochondrial DNA (mtDNA) damage. We report that levels of M1dG, a major endogenous peroxida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b5c891e8f51acd5d59e89ac1ddeb96
http://europepmc.org/articles/PMC5909422
http://europepmc.org/articles/PMC5909422
Autor:
James West, Anna R. Hemnes, Megha Talati, John H. Newman, Thomas R. Blackwell, Niki L Fortune, Joshua P. Fessel, Kevin D. Niswender, Aaron W. Trammell
Publikováno v:
Pulmonary Circulation
Pulmonary arterial hypertension (PAH) is associated with metabolic derangements including insulin resistance, although their effects on the cardiopulmonary disease are unclear. We hypothesized that insulin resistance promotes pulmonary hypertension (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4bf3df35ab3e7fc0fda0644a4cacee2
http://europepmc.org/articles/PMC5841889
http://europepmc.org/articles/PMC5841889
Autor:
Eric D. Austin, James West, Megha Talati, Ling Yan, Ferrin C. Wheeler, Rizwan Hamid, Joy D. Cogan, Thomas R. Blackwell, James E. Loyd, Bethany Nunley, Xinping Chen, Santhi Gladson
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 193:898-909
Rationale: Pulmonary arterial hypertension (PAH) is a progressive lung disease of the pulmonary microvasculature. Studies suggest that bone marrow (BM)-derived circulating cells may play an important role in its pathogenesis.Objectives: We used a gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::918bc5fb73531421056109ab292423f3
https://doi.org/10.1164/rccm.201502-0407oc
https://doi.org/10.1164/rccm.201502-0407oc
Autor:
Lucas J. McClellan, Melinda E. McConaha, Ankita Burman, Joshua P. Fessel, Andrew Bryant, Thomas R. Blackwell, Harikrishna Tanjore, Christy Moore, Linda Robinson, Niki Penner, Megha Talati, James West, Anna R. Hemnes, Vasiliy V. Polosukhin, Linda A. Gleaves, William Lawson, Santhi Gladson, Timothy S. Blackwell
Publikováno v:
Pulmonary Circulation. 5:681-690
Pulmonary fibrosis is often complicated by pulmonary hypertension (PH), and previous studies have shown a potential link between bone morphogenetic protein receptor II (BMPR2) and PH secondary to pulmonary fibrosis. We exposed transgenic mice express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cddc394b8e59a07e74fa3e45da0e7c3
https://doi.org/10.1086/683811
https://doi.org/10.1086/683811
Autor:
Kirk B. Lane, Outi Mutlak, James West, Anna R. Hemnes, Timothy S. Blackwell, Haitham Mutlak, Megha Talati, Thomas R. Blackwell, Wei Han, Rinat Zaynagetdinov
Publikováno v:
Diseases, Vol 2, Iss 2, Pp 148-167 (2014)
Diseases
Volume 2
Issue 2
Pages 148-167
Diseases
Volume 2
Issue 2
Pages 148-167
Aim: The present study investigates the role of NF-κB in Bmpr2-related pulmonary hypertension (PH) using a murine model of PH with inducible overexpression of a cytoplasmic tail Bmpr2 mutation. Methods and Results: Electrophoretic mobility shift ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb829a713c9cbcbb8a184c226d2b8776
https://doi.org/10.3390/diseases2020148
https://doi.org/10.3390/diseases2020148
Autor:
Christie J. Kang, Xinping Chen, Jennifer Johnson, Santhi Gladson, Andrea L. Frump, Thomas R. Blackwell, James E. Loyd, Joshua P. Fessel, James West, Anna R. Hemnes, Eric D. Austin
Publikováno v:
Pulmonary Circulation. 3:564-577
The majority of heritable pulmonary arterial hypertension (HPAH) cases are associated with mutations in bone morphogenetic protein receptor type 2 (BMPR2). BMPR2 mutation carries about a 20% lifetime risk of PAH development, but penetrance is approxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d901f8f2c01d19bf497d967613860631
https://doi.org/10.1086/674312
https://doi.org/10.1086/674312
Autor:
Christa Gaskill, Ayub K. Karwandyar, Niki Penner, James West, Anna R. Hemnes, Erica J. Carrier, Christy Moore, Andrew Bryant, Thomas R. Blackwell, Melinda E. McConaha, William Lawson, Edward W. Scott, Santhi Gladson, Vasiliy V. Polosukhin, Volker H. Haase, Susan M. Majka, Joshua P. Fessel, Hui-Jia Dong, Timothy S. Blackwell, Megha Talati, Linda A. Gleaves, Sheila Shay, Ankita Burman, Ryan P. Carrick, Harikrishna Tanjore, Brittany R. Jones
Pulmonary hypertension (PH) complicating chronic parenchymal lung disease, such as idiopathic pulmonary fibrosis, results in significant morbidity and mortality. Since the hypoxia-inducible factor (HIF) signaling pathway is important for development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4b4e27f4c7c6c6033258e50610019e
https://europepmc.org/articles/PMC4838140/
https://europepmc.org/articles/PMC4838140/
Autor:
Thomas R. Blackwell, Kirk B. Lane, Radhika Gaddipati, Kirsten A. Lane, Nicole M. Lane, James West, James E. Loyd
Publikováno v:
American Journal of Molecular Biology. :131-139
In this study, RLM-RACE was used to identify the transcriptional start site 387 bp upstream of the translational start. Evolutionarily conserved transcription factor binding sites were identified, and a series of luciferase reporter constructs driven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e311d9d909ab0dfd28a4269e63499122
https://doi.org/10.4236/ajmb.2011.13014
https://doi.org/10.4236/ajmb.2011.13014
Autor:
Kirk B. Lane, Peter F. Crossno, Timothy S. Blackwell, William Lawson, Juan Roldan, Carol Xu, Thomas R. Blackwell, Geraldine G. Miller, James E. Loyd, Cheryl Markin, Dong-Sheng Cheng, Lorraine B. Ware, Vasiliy V. Polosukhin
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 294:L1119-L1126
Recent evidence suggests that dysfunctional type II alveolar epithelial cells (AECs) contribute to the pathogenesis of idiopathic pulmonary fibrosis (IPF). Based on the hypothesis that disease-causing mutations in surfactant protein C ( SFTPC) provid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8376a75ddb66f9f1ba7d8a5003feb3c1
https://doi.org/10.1152/ajplung.00382.2007
https://doi.org/10.1152/ajplung.00382.2007
Autor:
Wei Han, Rinat Zaynagetdinov, Linda Robinson, Thomas R. Blackwell, Charles C. Hong, Timothy S. Blackwell, Megha Talati, Kirk B. Lane, James West
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 4, p e94119 (2014)
PLoS ONE, Vol 9, Iss 4, p e94119 (2014)
Pulmonary arterial hypertension (PAH) is a disease of progressively increasing pulmonary vascular resistance, associated with mutations of the type 2 receptor for the BMP pathway, BMPR2. The canonical signaling pathway for BMPR2 is through the SMAD f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a89d55fcc4d72409fa81434c85d3324
http://europepmc.org/articles/PMC3979749
http://europepmc.org/articles/PMC3979749