Zobrazeno 1 - 10 of 69 pro vyhledávání: '"Thomas R Shannon"'
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Akademický článek
Nitric oxide-dependent activation of CaMKII increases diastolic sarcoplasmic reticulum calcium release in cardiac myocytes in response to adrenergic stimulation.
Autor: Jerry Curran, Lifei Tang, Steve R Roof, Sathya Velmurugan, Ashley Millard, Stephen Shonts, Honglan Wang, Demetrio Santiago, Usama Ahmad, Matthew Perryman, Donald M Bers, Peter J Mohler, Mark T Ziolo, Thomas R Shannon
Publikováno v: PLoS ONE, Vol 9, Iss 2, p e87495 (2014)
Spontaneous calcium waves in cardiac myocytes are caused by diastolic sarcoplasmic reticulum release (SR Ca(2+) leak) through ryanodine receptors. Beta-adrenergic (β-AR) tone is known to increase this leak through the activation of Ca-calmodulin-dep
Externí odkaz: https://doaj.org/article/aa8b8f476611492086b0aa2f08cc14ff
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2
Subcellular Propagation of Cardiomyocyte β-Adrenergic Activation of Calcium Uptake Involves Internal β-Receptors and AKAP7
Autor: Thomas R Shannon, Dan J Bare, Sabine Van Dijk, Shayan Raofi, Tiffany N-M Huynh, Yang K Xiang, Julie Bossuyt, Kimberly L Dodge-Kafka, Kenneth S Ginsburg, Donald M Bers
Publikováno v: Function (Oxford, England), vol 3, iss 3
β-adrenergic receptor (β-AR) signaling in cardiac myocytes is central to cardiac function, but spatiotemporal activation within myocytes is unresolved. In rabbit ventricular myocytes, β-AR agonists or high extracellular [Ca] were applied locally a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec429494085285941ca1e456db67ae6d
https://pubmed.ncbi.nlm.nih.gov/36156892
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4
Sarcoplasmic reticulum Ca 2+ , Mg 2+ , K + , and Cl − concentrations adjust quickly as heart rate changes
Autor: Claudio Berti, Thomas R. Shannon, Dirk Gillespie, Michael Fill, Vilmos Zsolnay
Publikováno v: Journal of Molecular and Cellular Cardiology. 103:31-39
During systole, Ca2+ is released from the sarcoplasmic reticulum (SR) through ryanodine receptors (RyRs) while, simultaneously, other ions (specifically K+, Mg2+, and Cl−) provide counter-ion flux. These ions move back into the SR during diastole t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92584c2286e6d863439c4c84b1f3a75
https://doi.org/10.1016/j.yjmcc.2016.10.018
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6
Electrophysiological Determination of Submembrane Na + Concentration in Cardiac Myocytes
Autor: Thomas R. Shannon, Leighton T. Izu, Ye Chen-Izu, Tamás Bányász, Bence Hegyi
Publikováno v: Biophysical Journal. 111:1304-1315
In the heart, Na + is a key modulator of the action potential, Ca 2+ homeostasis, energetics, and contractility. Because Na + currents and cotransport fluxes depend on the Na + concentration in the submembrane region, it is necessary to accurately es
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa176fe0d19f490e8693a443b6c7155
https://doi.org/10.1016/j.bpj.2016.08.008
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7
Sarcoplasmic Reticulum Structure and Functional Properties that Promote Long-Lasting Calcium Sparks
Autor: Donald M. Bers, Daisuke Sato, Thomas R. Shannon
Publikováno v: Biophysical journal, vol 110, iss 2
Sato, D; Shannon, TR; & Bers, DM. (2016). Sarcoplasmic Reticulum Structure and Functional Properties that Promote Long-Lasting Calcium Sparks. Biophysical Journal, 110(2), 382-390. doi: 10.1016/j.bpj.2015.12.009. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/83b315kg
© 2016 Biophysical Society. Calcium (Ca) sparks are the fundamental sarcoplasmic reticulum (SR) Ca release events in cardiac myocytes, and they have a typical duration of 20-40 ms. However, when a fraction of ryanodine receptors (RyRs) are blocked b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d1004e08c3d8dc97a5e166875880a5a
https://doi.org/10.1016/j.bpj.2015.12.009
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