Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Thomas R Kolodecik"'
Autor:
Abrahim I Orabi, Yuhuan Luo, Mahwish U Ahmad, Ahsan U Shah, Zahir Mannan, Dong Wang, Sheharyar Sarwar, Kamaldeen A Muili, Christine Shugrue, Thomas R Kolodecik, Vijay P Singh, Mark E Lowe, Edwin Thrower, Ju Chen, Sohail Z Husain
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48465 (2012)
Acute pancreatitis is a painful, life-threatening disorder of the pancreas whose etiology is often multi-factorial. It is of great importance to understand the interplay between factors that predispose patients to develop the disease. One such factor
Externí odkaz:
https://doaj.org/article/889a475c5cc141099dabea9b3f1a094c
Autor:
Thomas R Kolodecik, Christine A Shugrue, Edwin C Thrower, Lonny R Levin, Jochen Buck, Fred S Gorelick
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41320 (2012)
An early feature of acute pancreatitis is activation of zymogens, such as trypsinogen, within the pancreatic acinar cell. Supraphysiologic concentrations of the hormone cholecystokinin (CCK; 100 nM), or its orthologue cerulein (CER), induce zymogen a
Externí odkaz:
https://doaj.org/article/b86bb9574ccb44619b53e44daa82011a
Autor:
Robert C. De Lisle, Andrew Ballabio, Thomas R. Kolodecik, Hong-Min Ni, Pal Pacher, Shaogui Wang, Xiaowen Ma, Wen-Xing Ding, Xiaojuan Chao
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 1, Pp 59-81 (2020)
Background & Aims Alcohol abuse is the major cause of experimental and human pancreatitis but the molecular mechanisms remain largely unknown. We investigated the role of transcription factor EB (TFEB), a master regulator of lysosomal biogenesis, in
Autor:
Thomas R. Kolodecik, Kimie Date, Shang-Lin Chung, Anamika Reed, Vikhil Patel, Fred S. Gorelick, Gary V. Desir, Christine A. Shugrue
Publikováno v:
Journal of Biological Chemistry. 292:21047-21059
Acute pancreatitis is a disease associated with inflammation and tissue damage. One protein that protects against acute injury, including ischemic injury to both the kidney and heart, is renalase, which is secreted into the blood by the kidney and ot
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 307:G24-G32
Decreased extracellular pH is observed in a number of clinical conditions and can sensitize to the development and worsen the severity of acute pancreatitis. Because intercellular communication through gap junctions is pH-sensitive and modulates panc
Autor:
Christine A. Shugrue, Anil B. Nagar, Petr Protiva, Thomas R. Kolodecik, Shang-Lin Chung, Gary V. Desir, Fred S. Gorelick
Publikováno v:
Gastroenterology. 156:S-324
Autor:
Rebecca Patton, Mohamed Shitia, Samantha N. Minervini, Thomas R. Kolodecik, Abdul Kareem Uduman, E. O. Akinbiyi, Edwin C. Thrower, Martine Alexandre, Fred S. Gorelick, Vikhil Patel, Christine A. Shugrue, Ali Raoof
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 303:G696-G704
Clinical studies indicate that cigarette smoking increases the risk for developing acute pancreatitis. The nicotine metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a major cigarette smoke toxin. We hypothesized that NNK could sensi
Autor:
Martine Alexandre, Alexander P. E. Diaz de Villalvilla, Fred S. Gorelick, Edwin C. Thrower, Thomas R. Kolodecik, Christine A. Shugrue, Lawrence H. Young
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 303:G723-G732
The premature activation of digestive enzyme zymogens in the pancreatic acinar cell is an important initiating event in acute pancreatitis. We have previously demonstrated that vacuolar ATPase (vATPase) activity is required for zymogen activation. Ad
Publikováno v:
Open Access Animal Physiology. 1:1-11
Thomas Kolodecik1,3, Fred Gorelick1–3, Edwin Thrower1,31Department of Internal Medicine, Section of Digestive Diseases, 2Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA; 3Veterans Administration Connecticut Health
Autor:
Jingzhen Yuan, Fred S. Gorelick, Jeffrey Wang, Aurelia Lugea, Thomas R. Kolodecik, Joseph R. Reeve, Edwin C. Thrower, Salim Cheriyan, Stephen J. Pandol
Publikováno v:
Pancreas. 38:930-935
To define the role of protein kinase C delta (PKC delta) in acinar cell responses to the hormone cholecystokinin-8 (CCK) using isoform-specific inhibitors and a previously unreported genetic deletion model.Pancreatic acinar cells were isolated from (