Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Thomas R Klei"'
Autor:
Bin Zhan, Sridhar Arumugam, Malcolm W Kennedy, Nancy Tricoche, Lu-Yun Lian, Oluwatoyin A Asojo, Sasisekhar Bennuru, Maria Elena Bottazzi, Peter J Hotez, Sara Lustigman, Thomas R Klei
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 10, p e0006772 (2018)
Parasitic nematodes produce an unusual class of fatty acid and retinol (FAR)-binding proteins that may scavenge host fatty acids and retinoids. Two FARs from Brugia malayi (Bm-FAR-1 and Bm-FAR-2) were expressed as recombinant proteins, and their liga
Externí odkaz:
https://doaj.org/article/be720cd2deef495e82184ab8a43694e8
Autor:
Cassan N Pulaski, John B Malone, Catherine Bourguinat, Roger Prichard, Timothy Geary, Danielle Ward, Thomas R Klei, Tal Guidry, George `Bud’ Smith, Brooke Delcambre, Jonathan Bova, Jenny Pepping, James Carmichael, Rudolf Schenker, Romain Pariaut
Publikováno v:
Parasites & Vectors, Vol 7, Iss 1, Pp 1-9 (2014)
Abstract Background Strains of Dirofilaria immitis suspected of lack of efficacy (LOE) to macrocyclic lactone (ML) preventive drugs have been increasingly reported in dogs by practicing veterinarians since 2005 in the Lower Mississippi Delta region.
Externí odkaz:
https://doaj.org/article/90c213ed79404109adad7c39348acf67
Publikováno v:
Parasites & Vectors, Vol 7, Iss 1, Pp 1-7 (2014)
Abstract Background Cysteine protease inhibitors of Brugia malayi have been ascribed to be involved in parasite development as well as to immunomodulate the host’s immune response. In Onchocerca volvulus, Onchocystatin has been shown to induce part
Externí odkaz:
https://doaj.org/article/c0fca91568ec4b2d9c71aef0a0bab53b
Autor:
Jessica A Hess, Bin Zhan, April R Torigian, John B Patton, Nikolai Petrovsky, Tingting Zhan, Maria Elena Bottazzi, Peter J Hotez, Thomas R Klei, Sara Lustigman, David Abraham
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 7, p e0004797 (2016)
BACKGROUND:In some regions in Africa, elimination of onchocerciasis may be possible with mass drug administration, although there is concern based on several factors that onchocerciasis cannot be eliminated solely through this approach. A vaccine aga
Externí odkaz:
https://doaj.org/article/1b8bd271a8604e77913fb5d8759815b5
Autor:
Sridhar Arumugam, Junfei Wei, Zhuyun Liu, David Abraham, Aaron Bell, Maria Elena Bottazzi, Peter J Hotez, Bin Zhan, Sara Lustigman, Thomas R Klei
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 4, p e0004586 (2016)
BACKGROUND:The Brugia malayi Bm-103 and Bm-RAL-2 proteins are orthologous to Onchocerca volvulus Ov-103 and Ov-RAL-2, and which were selected as the best candidates for the development of an O. volvulus vaccine. The B. malayi gerbil model was used to
Externí odkaz:
https://doaj.org/article/95bd6f868063411c96b116b02278eee9
Autor:
Peter J Hotez, Maria Elena Bottazzi, Bin Zhan, Benjamin L Makepeace, Thomas R Klei, David Abraham, David W Taylor, Sara Lustigman
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 1, p e0003422 (2015)
Externí odkaz:
https://doaj.org/article/f363a2a6d8e04595a0d2fb3b55265ebc
Autor:
Sasisekhar Bennuru, Sara Lustigman, Bin Zhan, Maria Elena Bottazzi, Peter J. Hotez, Nancy Tricoche, Thomas R. Klei, Oluwatoyin A. Asojo, Malcolm W. Kennedy, Lu-Yuan Lian, Sridhar Arumugam
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 12, Iss 10, p e0006772 (2018)
PLoS Neglected Tropical Diseases, Vol 12, Iss 10, p e0006772 (2018)
Parasitic nematodes produce an unusual class of fatty acid and retinol (FAR)-binding proteins that may scavenge host fatty acids and retinoids. Two FARs from Brugia malayi (Bm-FAR-1 and Bm-FAR-2) were expressed as recombinant proteins, and their liga
Autor:
Maria Elena Bottazzi, David Abraham, Benjamin L. Makepeace, Peter J. Hotez, Simon A. Babayan, Sara Lustigman, Thomas R. Klei
Publikováno v:
TRENDS IN PARASITOLOGY
Human onchocerciasis - commonly known as river blindness - is one of the most devastating yet neglected tropical diseases, leaving many millions in sub-Saharan Africa blind and/or with chronic disabilities. Attempts to eliminate onchocerciasis, prima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e3bb07e69a5d14d98e107ef91268af
http://livrepository.liverpool.ac.uk/3009733/1/TREPAR-D-17-00158_R1.pdf
http://livrepository.liverpool.ac.uk/3009733/1/TREPAR-D-17-00158_R1.pdf
Autor:
Sara Lustigman, David Abraham, Danielle Ward, Bin Zhan, Sridhar Arumugam, Thomas R. Klei, Junfei Wei
Publikováno v:
International Journal for Parasitology. 44:675-679
Vaccination of Mongolian gerbils with Brugia malayi cysteine protease inhibitor-2 in which the amino acid Asn66 was mutated to Lys66 (Bm-CPI-2M) resulted in reduced parasite numbers of 48.6% and 48.0 % at 42 and 90 days p.i. with B. malayi L3s. Ferti
Autor:
Sara Lustigman, Jessica M. Deckman, Thomas R. Klei, Sandra Bonne-Année, Jessica A. Hess, David Abraham, Peter J. Hotez, Bin Zhan, Maria Elena Bottazzi
Publikováno v:
International Journal for Parasitology. 44:637-646
Human onchocerciasis is a neglected tropical disease caused by Onchocerca volvulus and an important cause of blindness and chronic disability in the developing world. Although mass drug administration of ivermectin has had a profound effect on contro