Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Thomas R, Fuerst"'
Autor:
Matthew C. Metcalf, Benjamin M. Janus, Rui Yin, Ruixue Wang, Johnathan D. Guest, Edwin Pozharski, Mansun Law, Roy A. Mariuzza, Eric A. Toth, Brian G. Pierce, Thomas R. Fuerst, Gilad Ofek
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Hepatitis C virus (HCV) is a major global health burden as the leading causative agent of chronic liver disease and hepatocellular carcinoma. While the main antigenic target for HCV-neutralizing antibodies is the membrane-associated E1E2 sur
Externí odkaz:
https://doaj.org/article/5c8f3813e8b4474bb3fa9ada06482823
Autor:
Brian G. Pierce, Nathaniel Felbinger, Matthew Metcalf, Eric A. Toth, Gilad Ofek, Thomas R. Fuerst
Publikováno v:
Viruses, Vol 16, Iss 5, p 803 (2024)
Hepatitis C virus (HCV) is a major medical health burden and the leading cause of chronic liver disease and cancer worldwide. More than 58 million people are chronically infected with HCV, with 1.5 million new infections occurring each year. An effec
Externí odkaz:
https://doaj.org/article/af9cc06e950b41f584ef5b3cb302dc5d
Autor:
Yingwei Chen, Eric A. Toth, Biao Ruan, Eun Jung Choi, Richard Simmerman, Yihong Chen, Yanan He, Ruixue Wang, Raquel Godoy-Ruiz, Harlan King, Gregory Custer, D. Travis Gallagher, David A. Rozak, Melani Solomon, Silvia Muro, David J. Weber, John Orban, Thomas R. Fuerst, Philip N. Bryan
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Chen et al. describe a rational design of subtilisin mutants that degrade active RAS by cleaving a conserved sequence in switch 2. They further modified the active site to be dependent on a cofactor to generate high target specificity. Proteases engi
Externí odkaz:
https://doaj.org/article/742c1a3e0584400b8b631c6e4a1b0ff6
Autor:
Harichandra D. Tagad, Alexander Marin, Ruixue Wang, Abdul S. Yunus, Thomas R. Fuerst, Alexander K. Andrianov
Publikováno v:
Molecules, Vol 28, Iss 10, p 4218 (2023)
The inclusion of fluorine motifs in drugs and drug delivery systems is an established tool for modulating their biological potency. Fluorination can improve drug specificity or boost the vehicle’s ability to cross cellular membranes. However, the a
Externí odkaz:
https://doaj.org/article/c1bba17057a84218a9ce32a36ced909b
Autor:
Andrey Romanyuk, Ruixue Wang, Alexander Marin, Benjamin M. Janus, Eric I. Felner, Dengning Xia, Yenny Goez-Gazi, Kendra J. Alfson, Abdul S. Yunus, Eric A. Toth, Gilad Ofek, Ricardo Carrion, Mark R. Prausnitz, Thomas R. Fuerst, Alexander K. Andrianov
Publikováno v:
Journal of Functional Biomaterials, Vol 14, Iss 1, p 16 (2022)
Ebolavirus (EBOV) infection in humans is a severe and often fatal disease, which demands effective interventional strategies for its prevention and treatment. The available vaccines, which are authorized under exceptional circumstances, use viral vec
Externí odkaz:
https://doaj.org/article/a885540978ff4542aea23a7fac2aa739
Autor:
Benjamin M. Janus, Nydia van Dyk, Xuelian Zhao, Katie A. Howell, Cinque Soto, M. Javad Aman, Yuxing Li, Thomas R. Fuerst, Gilad Ofek
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
The Ebola virus glycoprotein is a target for cross-protective antibodies. Here, Janus et al. report the crystal structure of the antigen-binding fragment of a pan-reactive antibody bound to a conserved epitope of the glycoprotein, facilitating ration
Externí odkaz:
https://doaj.org/article/20e66fb349b04412a89f063ca2921f9c
Autor:
Frances Rocamora, Angelo G Peralta, Seunghyeon Shin, James Sorrentino, Mina Wu, Eric A Toth, Thomas R Fuerst, Nathan E Lewis
Over recent decades, therapeutic proteins have had widespread success in treating a myriad of diseases. Glycosylation, a near universal feature of this class of drugs, is a critical quality attribute that significantly influences the physical propert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2b87fec95f855bab48b07427add325
https://doi.org/10.20944/preprints202303.0072.v1
https://doi.org/10.20944/preprints202303.0072.v1
Publikováno v:
Viruses, Vol 13, Iss 6, p 981 (2021)
Development of preventive vaccines against hepatitis C virus (HCV) remains one of the main strategies in achieving global elimination of the disease. The effort is focused on the quest for vaccines capable of inducing protective cross-neutralizing hu
Externí odkaz:
https://doaj.org/article/81d153e0c0a34f2d80a371f56504d7a6
Publikováno v:
Viruses, Vol 13, Iss 6, p 1027 (2021)
An effective vaccine for the hepatitis C virus (HCV) is a major unmet medical and public health need, and it requires an antigen that elicits immune responses to multiple key conserved epitopes. Decades of research have generated a number of vaccine
Externí odkaz:
https://doaj.org/article/15f70596146a4edd86604c3d60c91b4c
Autor:
Bareera Qamar, Melani Solomon, Alexander Marin, Thomas R. Fuerst, Alexander K. Andrianov, Silvia Muro
Publikováno v:
Pharmaceutics, Vol 13, Iss 2, p 249 (2021)
Achieving intracellular delivery of protein therapeutics within cells remains a significant challenge. Although custom formulations are available for some protein therapeutics, the development of non-toxic delivery systems that can incorporate a vari
Externí odkaz:
https://doaj.org/article/a647b9cadc994d55bfcf9c3e6fc770c3