Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Thomas R, Eykyn"'
Autor:
Yu Jin Chung, Zoe Hoare, Friedrich Baark, Chak Shun Yu, Jia Guo, William Fuller, Richard Southworth, Doerthe M. Katschinski, Michael P. Murphy, Thomas R. Eykyn, Michael J. Shattock
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Elevated intracellular sodium Nai adversely affects mitochondrial metabolism and is a common feature of heart failure. The reversibility of acute Na induced metabolic changes is evaluated in Langendorff perfused rat hearts using the Na/K ATP
Externí odkaz:
https://doaj.org/article/8ac1f41d178b4502b68cf04de0eb6baa
Autor:
Aidan M. Michaels, Anna Zoccarato, Zoe Hoare, George Firth, Yu Jin Chung, Philip W. Kuchel, Ajay M. Shah, Michael J. Shattock, Richard Southworth, Thomas R. Eykyn
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Background Glycolytic flux is regulated by the energy demands of the cell. Upregulated glycolysis in cancer cells may therefore result from increased demand for adenosine triphosphate (ATP), however it is unknown what this extra ATP turnover
Externí odkaz:
https://doaj.org/article/61fe531d26c740f2a46c9ccc1181bfa7
Autor:
Chris G. Faulkes, Thomas R. Eykyn, Jan Lj. Miljkovic, James D. Gilbert, Rebecca L. Charles, Hiran A. Prag, Nikayla Patel, Daniel W. Hart, Michael P. Murphy, Nigel C. Bennett, Dunja Aksentijevic
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The naked mole-rat Heterocephalus glaber is a eusocial mammal exhibiting extreme longevity (37-year lifespan), extraordinary resistance to hypoxia and absence of cardiovascular disease. To identify the mechanisms behind these exceptional tra
Externí odkaz:
https://doaj.org/article/b11379dc99224d37894391422adcf90e
Autor:
Dunja Aksentijević, Anja Karlstaedt, Marina V. Basalay, Brett A. O’Brien, David Sanchez-Tatay, Seda Eminaga, Alpesh Thakker, Daniel A. Tennant, William Fuller, Thomas R. Eykyn, Heinrich Taegtmeyer, Michael J. Shattock
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The failing heart is characterised by both alterations in mitochondrial metabolism and an elevation of cytosolic sodium. Here, the authors use 23Na NMR and metabolic profiling to show these are related, and that elevation in intracellular Na reprogra
Externí odkaz:
https://doaj.org/article/01651cc80f9b4aad9898d7152d51f740
Publikováno v:
Redox Biology, Vol 47, Iss , Pp 102155- (2021)
The cellular effects of hydrogen sulfide (H2S) signaling may be partially mediated by the formation of alkyl persulfides from thiols, such as glutathione and protein cysteine residues. Persulfides are potent nucleophiles and reductants and therefore
Externí odkaz:
https://doaj.org/article/ae13c340f5d74bcb98d687fc0772327f
Autor:
Aline Xavier, Flavia Zacconi, Fabián Santana-Romo, Thomas R. Eykyn, Begoña Lavin, Alkystis Phinikaridou, René Botnar, Sergio Uribe, Juan Esteban Oyarzún, Daniel Cabrera, Marco Arrese, Marcelo E. Andia
Publikováno v:
Annals of Hepatology, Vol 25, Iss , Pp 100358- (2021)
Introduction and objectives: Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver abnormalities including steatosis, steatohepatitis, fibrosis, and cirrhosis. Liver biopsy remains the gold standard method to determine the disease
Externí odkaz:
https://doaj.org/article/e21f3dc96e3648c897783a2431c6c217
Autor:
Sevasti Zervou, Debra J. McAndrew, Hannah J. Whittington, Hannah A. Lake, Kyung Chan Park, Kuan Minn Cha, Philip J. Ostrowski, Thomas R. Eykyn, Jürgen E. Schneider, Stefan Neubauer, Craig A. Lygate
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
AimsAdenylate kinase 1 (AK1) catalyses the reaction 2ADP ↔ ATP + AMP, extracting extra energy under metabolic stress and promoting energetic homeostasis. We hypothesised that increased AK1 activity would have negligible effects at rest, but protect
Externí odkaz:
https://doaj.org/article/4987ce7164ec4b948b413bb6efbed548
Autor:
Dunja Aksentijević, Sevasti Zervou, Thomas R. Eykyn, Debra J. McAndrew, Julie Wallis, Jurgen E. Schneider, Stefan Neubauer, Craig A. Lygate
Publikováno v:
Frontiers in Physiology, Vol 10 (2020)
AimGuanidinoacetate N-methyltransferase (GAMT) is the second essential enzyme in creatine (Cr) biosynthesis. Short-term Cr deficiency is metabolically well tolerated as GAMT–/– mice exhibit normal exercise capacity and response to ischemic heart
Externí odkaz:
https://doaj.org/article/a17d9c8f7cff4d13bb919761852314e7
Autor:
Chris G. Faulkes, Thomas R. Eykyn, Jan Lj. Miljkovic, Rebecca L. Charles, Hiran A. Prag, Nikayla Patel, Daniel W. Hart, Michael P. Murphy, Nigel C. Bennett, Dunja Aksentijevic
The naked mole-ratHeterocephalus glaberis a eusocial mammal exhibiting extreme longevity (37-year lifespan), extraordinary resistance to hypoxia and absence of cardiovascular disease. To identify the mechanisms behind these exceptional traits, RNAseq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fef184b370018300717ba158bd97c91
https://doi.org/10.1101/2023.05.19.541451
https://doi.org/10.1101/2023.05.19.541451
Autor:
Begoña Lavin, Thomas R. Eykyn, Alkystis Phinikaridou, Aline Xavier, Shravan Kumar, Xabier Buqué, Patricia Aspichueta, Carlos Sing‐Long, Marco Arrese, René M. Botnar, Marcelo E. Andia
Publikováno v:
NMR in Biomedicine.