Zobrazeno 1 - 10
of 451
pro vyhledávání: '"Thomas Quertermous"'
Autor:
Jiehan Li, Christopher Jin, Stefan Gustafsson, Abhiram Rao, Martin Wabitsch, Chong Y. Park, Thomas Quertermous, Joshua W. Knowles, Ewa Bielczyk-Maczynska
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-10 (2023)
Abstract Adipogenesis is a process in which fat-specific progenitor cells (preadipocytes) differentiate into adipocytes that carry out the key metabolic functions of the adipose tissue, including glucose uptake, energy storage, and adipokine secretio
Externí odkaz:
https://doaj.org/article/0a722d0cb0694bfa8551d9ed0044cc3d
Autor:
Hyun-Jung Kim, Paul Cheng, Stanislao Travisano, Chad Weldy, João P. Monteiro, Ramendra Kundu, Trieu Nguyen, Disha Sharma, Huitong Shi, Yi Lin, Boxiang Liu, Saptarsi Haldar, Simon Jackson, Thomas Quertermous
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Genes encode risk for coronary disease, identifying how they function is critical to developing new therapies. In work reported the authors have identified one culprit gene, PDGFD, and studied how it functions to promote disease risk.
Externí odkaz:
https://doaj.org/article/1f946cc4346c421b9a9fc85922c6c147
Autor:
Stanislao Igor Travisano, Michael R.M. Harrison, Matthew E. Thornton, Brendan H. Grubbs, Thomas Quertermous, Ching-Ling Lien
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113106- (2023)
Summary: Cardiac lymphatic vessels play important roles in fluid homeostasis, inflammation, disease, and regeneration of the heart. The developing cardiac lymphatics in human fetal hearts are closely associated with coronary arteries, similar to thos
Externí odkaz:
https://doaj.org/article/66eada1a9c3d400fb3208df2169fb9cc
Autor:
Michael J. Gloudemans, Brunilda Balliu, Daniel Nachun, Theresia M. Schnurr, Matthew G. Durrant, Erik Ingelsson, Martin Wabitsch, Thomas Quertermous, Stephen B. Montgomery, Joshua W. Knowles, Ivan Carcamo-Orive
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-16 (2022)
Abstract Background Identification of causal genes for polygenic human diseases has been extremely challenging, and our understanding of how physiological and pharmacological stimuli modulate genetic risk at disease-associated loci is limited. Specif
Externí odkaz:
https://doaj.org/article/12c82faabb1c4c369882ad7b83a07948
Autor:
Nikolaos T. Skenteris, Till Seime, Anna Witasp, Eva Karlöf, Grzegorz B. Wasilewski, Marina A. Heuschkel, Armand M.G. Jaminon, Loureen Oduor, Robert Dzhanaev, Malin Kronqvist, Mariette Lengquist, Frederique E.C.M. Peeters, Magnus Söderberg, Rebecka Hultgren, Joy Roy, Lars Maegdefessel, Hildur Arnardottir, Eva Bengtsson, Isabel Goncalves, Thomas Quertermous, Claudia Goettsch, Peter Stenvinkel, Leon J. Schurgers, Ljubica Matic
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 2, Pp n/a-n/a (2022)
Abstract Rationale Vascular calcification is a prominent feature of late‐stage diabetes, renal and cardiovascular disease (CVD), and has been linked to adverse events. Recent studies in patients reported that plasma levels of osteomodulin (OMD), a
Externí odkaz:
https://doaj.org/article/7f1255b91c9c4ad38f68f2fed7276dc9
Autor:
Quanyi Zhao, Michael Dacre, Trieu Nguyen, Milos Pjanic, Boxiang Liu, Dharini Iyer, Paul Cheng, Robert Wirka, Juyong Brian Kim, Hunter B. Fraser, Thomas Quertermous
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-23 (2020)
Abstract Background To investigate the epigenetic and transcriptional mechanisms of coronary artery disease (CAD) risk, as well as the functional regulation of chromatin structure and function, we create a catalog of genetic variants associated with
Externí odkaz:
https://doaj.org/article/5ffa8b35de57461e8faed264b5b9debe
Autor:
Mohsen Fathzadeh, Jiehan Li, Abhiram Rao, Naomi Cook, Indumathi Chennamsetty, Marcus Seldin, Xiang Zhou, Panjamaporn Sangwung, Michael J. Gloudemans, Mark Keller, Allan Attie, Jing Yang, Martin Wabitsch, Ivan Carcamo-Orive, Yuko Tada, Aldons J. Lusis, Myung Kyun Shin, Cliona M. Molony, Tracey McLaughlin, Gerald Reaven, Stephen B. Montgomery, Dermot Reilly, Thomas Quertermous, Erik Ingelsson, Joshua W. Knowles
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Genetic variants in the FAM13A locus have been associated with anthropometric and glycemic traits. Here, using fine-mapping, in vitro knockdown studies in pre-adipocytes and in vivo knockout in mice, the authors show that FAM13A is involved in regula
Externí odkaz:
https://doaj.org/article/bc1db2e1724a4f73a77947050955442a
Autor:
Samuel Röhl, MD, PhD, Urszula Rykaczewska, MSc, Till Seime, MSc, Bianca E. Suur, MSc, Maria Gonzalez Diez, PhD, Jesper R. Gådin, PhD, Anastasiia Gainullina, MSc, Alexey A. Sergushichev, PhD, Robert Wirka, MD, PhD, Mariette Lengquist, MSc, Malin Kronqvist, MSc, Otto Bergman, PhD, Jacob Odeberg, MD, PhD, Jan H.N. Lindeman, MD, PhD, Thomas Quertermous, MD, PhD, Anders Hamsten, MD, PhD, Per Eriksson, MSc, PhD, Ulf Hedin, MD, PhD, Anton Razuvaev, MD, PhD, Ljubica Perisic Matic, MSc, PhD
Publikováno v:
JVS - Vascular Science, Vol 1, Iss , Pp 13-27 (2020)
Objective: Endovascular interventions cause arterial injury and induce a healing response to restore vessel wall homeostasis. Complications of defective or excessive healing are common and result in increased morbidity and repeated interventions. Exp
Externí odkaz:
https://doaj.org/article/9d0b58197fa3444eb407e5862a0006ad
Autor:
Sampath Narayanan, Sofija Vuckovic, Robert Wirka, Mariette Lengquist, Thomas Quertermous, Ulf Hedin, Ljubica Matic
Publikováno v:
JVS - Vascular Science, Vol 3, Iss , Pp 413- (2022)
Externí odkaz:
https://doaj.org/article/cb0ec5b5acf0475f9f86f51bc559c879
Autor:
Casimiro Castillejo-Lopez, Milos Pjanic, Anna Chiara Pirona, Susanne Hetty, Martin Wabitsch, Claes Wadelius, Thomas Quertermous, Erik Arner, Erik Ingelsson
Publikováno v:
iScience, Vol 20, Iss , Pp 42-59 (2019)
Summary: We combined CAGE sequencing in human adipocytes during differentiation with data from genome-wide association studies to identify an enhancer in the SNX10 locus on chromosome 7, presumably involved in body fat distribution. Using reporter as
Externí odkaz:
https://doaj.org/article/f873f81f776f44f782763874e3c8e5fd