Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Thomas Porstmann"'
Autor:
Eduard Sabidó, Yibo Wu, Lucia Bautista, Thomas Porstmann, Ching‐Yun Chang, Olga Vitek, Markus Stoffel, Ruedi Aebersold
Publikováno v:
Molecular Systems Biology, Vol 9, Iss 1, Pp 1-12 (2013)
Abstract The metabolic syndrome is a collection of risk factors including obesity, insulin resistance and hepatic steatosis, which occur together and increase the risk of diseases such as diabetes, cardiovascular disease and cancer. In spite of inten
Externí odkaz:
https://doaj.org/article/3de00d37ca5540ba9fb1fd681a26a226
Publikováno v:
Blood. 138:1041-1041
Relative to the general population, health-related quality of life (HRQoL) is impaired in patients with hemophilia, who report increased pain and reduced physical activity. It is therefore of interest to assess the change in HRQoL after long-term pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::391b63f4c3804f6494a309dce70e0c1a
https://doi.org/10.1182/blood-2021-152257
https://doi.org/10.1182/blood-2021-152257
Autor:
S. C Tamer, Jesper Haaning, Josephine Skovgaard Rasmussen, Stephanie Seremetis, Trine Høyer Rose, Thomas Porstmann, Katarina Cepo
Publikováno v:
Blood. 136:40-40
Introduction Concizumab, a humanized recombinant monoclonal antibody directed against the tissue factor pathway inhibitor, is under investigation as a subcutaneous prophylactic treatment for patients with hemophilia A or B (HA/HB) with and without in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f2e66b37435318bcbdcf5ec4669a9bb
https://doi.org/10.1182/blood-2020-139563
https://doi.org/10.1182/blood-2020-139563
Publikováno v:
Blood. 134:2419-2419
Introduction Concizumab is an anti-tissue factor pathway inhibitor (TFPI) monoclonal antibody in clinical development for the subcutaneous prophylactic treatment of hemophilia patients. We present exploratory analyses assessing the impact of concizum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd12cdd9a41fc19f9b3b0043b150478f
https://doi.org/10.1182/blood-2019-122827
https://doi.org/10.1182/blood-2019-122827
Autor:
Nathalie Selevsek, Ruedi Aebersold, Emanuel Gasser, Thomas Porstmann, Markus Stoffel, Ferdinand von Meyenn, Alexander Schmidt
Publikováno v:
Cell Metabolism. 17:436-447
SummaryCirculating levels of insulin and glucagon reflect the nutritional state of animals and elicit regulatory responses in the liver that maintain glucose and lipid homeostasis. The transcription factor Foxa2 activates lipid metabolism and ketogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c392100f6936bfc6c688f74624b0047
https://doi.org/10.1016/j.cmet.2013.01.014
https://doi.org/10.1016/j.cmet.2013.01.014
Autor:
Sally J. Leevers, Almut Schulze, Mary Wu, B. Griffiths, Claudio R. Santos, John R. Griffiths, Megan Cully, Yuen-Li Chung, Thomas Porstmann
Publikováno v:
Cell Metabolism. 8(3):224-236
SummaryCell growth (accumulation of mass) needs to be coordinated with metabolic processes that are required for the synthesis of macromolecules. The PI3-kinase/Akt signaling pathway induces cell growth via activation of complex 1 of the target of ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfdb58e5836f5be6e277f32aab056a21
Autor:
Yuen-Li Chung, Julian Downward, Thomas Porstmann, John R. Griffiths, Oona Delpuech, Beatrice Griffiths, Almut Schulze
Publikováno v:
Oncogene. 24:6465-6481
Protein kinase B (PKB/Akt) has been shown to play a role in protection from apoptosis, cell proliferation and cell growth. It is also involved in mediating the effects of insulin, such as lipogenesis, glucose uptake and conversion of glucose into fat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb3550ce62b2098bb5afafd0b8cd0c6
https://doi.org/10.1038/sj.onc.1208802
https://doi.org/10.1038/sj.onc.1208802
Publikováno v:
Journal of Biological Chemistry. 279:1191-1196
Sister chromatid cohesion is resolved at anaphase onset when separase, a site-specific protease, cleaves the Scc1 subunit of the chromosomal cohesin complex that is responsible for holding sister chromatids together. This mechanism to initiate anapha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bceccdc6694a5148faab5f2b0991f1b7
https://doi.org/10.1074/jbc.m309761200
https://doi.org/10.1074/jbc.m309761200
Autor:
Olga Vitek, Ruedi Aebersold, Lucia Bautista, Eduard Sabidó, Markus Stoffel, Yibo Wu, Ching-Yun Chang, Thomas Porstmann
Publikováno v:
Molecular Systems Biology, 9 (1)
Molecular Systems Biology
Molecular Systems Biology
Quantitative measurement of proteins involved in insulin signaling and central metabolism in C57BL/6J and 129Sv mice subjected to a sustained high-fat diet reveals that the two strains diverge early in their response to the feeding regimen.
Quan
Quan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9e4e4169a163f1460ece5930a09a182
https://doi.org/10.1038/msb.2013.36
https://doi.org/10.1038/msb.2013.36
Publikováno v:
Biochemical Society transactions. 37(Pt 1)
Cell growth requires co-ordinated regulation of processes that provide metabolites for the synthesis of macromolecules such as proteins and membrane lipids. In recent years, a lot of emphasis has been placed on the activation of protein synthesis by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5160be3b87436a1d0e2a210f649ee232
https://pubmed.ncbi.nlm.nih.gov/19143646
https://pubmed.ncbi.nlm.nih.gov/19143646