Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Thomas Pomposelli"'
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
In recent years islet cell transplant has proven itself to be a viable clinical option for a select group of diabetic patients. Graft loss after transplant however continues to hinder the long-term success of the procedure. Transplanting the islets a
Externí odkaz:
https://doaj.org/article/6d922f7db96b464a857b88173c06c1f7
Autor:
Kazuhiko Yamada, Katsunori Miyake, Kazuhiro Takeuchi, Xiaojuan Chen, Anna Moore, Yuichi Ariyoshi, Hironosuke Watanabe, Neil M. Robertson, Thomas Pomposelli, Akira Shimizu, Ping Wang
Publikováno v:
Diabetes
The long-term success of pancreatic islet transplantation (Tx) as a cure for type 1 diabetes remains limited. Islet loss after Tx related to apoptosis, inflammation, and other factors continues to limit Tx efficacy. In this project, we demonstrate a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1c09852b8af6ccc6e25b4ee02021ec8
https://doi.org/10.2337/db20-0517
https://doi.org/10.2337/db20-0517
Autor:
Gabriel Cara-Fuentes, Dilrukshi K. Ekanayake‐Alper, Hironosuke Watanabe, David H. Sachs, Lennan Boyd, Gabriela E. Garcia, Kazuhiro Takeuchi, Megan Sykes, Thomas Pomposelli, Yuichiro Okumura, Kazuhiko Yamada, Dasari Amarnath, Akira Shimizu, Richard J. Johnson, Yuichi Ariyoshi
Publikováno v:
Xenotransplantation
Background Nephrotic syndrome is a common complication of pig-to-baboon kidney xenotransplantation (KXTx) that adversely affects outcomes. We have reported that upregulation of CD80 and down-regulation of SMPDL-3b in glomeruli have an important role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1091df2f327cf4574f62116796660170
https://europepmc.org/articles/PMC8957703/
https://europepmc.org/articles/PMC8957703/
Autor:
Yuichi Ariyoshi, Kazuhiko Yamada, Akira Shimizu, Dilrukshi K. Ekanayake‐Alper, David H. Sachs, Megan Sykes, Lennan Boyd, J. Scott Arn, Arsenoi Asfour, Ermance Estime, Thomas Pomposelli, Kazuhiro Takeuchi, David Ayares, Mayu Ohta, Marc I Lorber
Publikováno v:
Xenotransplantation
BACKGROUND: Recent advances in gene editing technology have enabled the production of multi-knockout (KO) and transgenic pigs in order to overcome immunologic barriers in xenotransplantation (XTx). However, the genetic manipulations required to produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7929305c7e5b0f689f54c892953d388
https://europepmc.org/articles/PMC8957702/
https://europepmc.org/articles/PMC8957702/
Autor:
Anna Moore, Kazuhiko Yamada, Neil Robertson, Akira Shimizu, Xiaojuan Chen, Hironosuke Watanabe, Yuichi Ariyoshi, Katsunori Miyake, Kazuhiro Takeuchi, Ping Wang, Thomas Pomposelli, Ada Admin
The long-term success of pancreatic islet transplantation (Tx) as a cure for type 1 diabetes remains limited. Islet loss after Tx related to apoptosis, inflammation and other factors continues to limit its efficacy. In this project we demonstrate a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f46c02cfdbd36bb8a6cb1b145920e80
https://doi.org/10.2337/figshare.12857708
https://doi.org/10.2337/figshare.12857708
Publikováno v:
Methods Mol Biol
Xenotransplantation ISBN: 9781071602546
Xenotransplantation ISBN: 9781071602546
Using advanced gene editing technologies, xenotransplantation from multi-transgenic alpha-1,3-galacto-syltransferase knockout pigs has demonstrated marked prolongation of renal xenograft survival, ranging from days to greater than several months for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7068a33ee7454e3aef5c5a868b1f474a
https://pubmed.ncbi.nlm.nih.gov/32002908
https://pubmed.ncbi.nlm.nih.gov/32002908
Publikováno v:
Methods Mol Biol
Xenotransplantation ISBN: 9781071602546
Xenotransplantation ISBN: 9781071602546
Mixed chimerism and thymic tissue transplantation strategies have achieved xenogeneic tolerance in pig-to-mouse models, and both have been extended to pig-to-baboon models. A mixed chimerism strategy has shown promise toward inducing tolerance in all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::769c655a60eaa91df704c59b2287f139
https://pubmed.ncbi.nlm.nih.gov/32002911
https://pubmed.ncbi.nlm.nih.gov/32002911
Publikováno v:
Journal of Plastic, Reconstructive & Aesthetic Surgery. 71:1123-1128
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34811702c922d75386a7e62c1ef0cfe
https://doi.org/10.1016/j.bjps.2018.05.041
https://doi.org/10.1016/j.bjps.2018.05.041
Autor:
Kazuhiro Takeuchi, Kazuhiko Yamada, Richard J. Johnson, Gabriela E. Garcia, Megan Sykes, David H. Sachs, David Ayares, Masayuki Tasaki, Hironosuke Watanabe, Yuichi Ariyoshi, Thomas Pomposelli, Shunichiro Nomura
Publikováno v:
Xenotransplantation
Background Our initial studies utilizing a galactosyl-α1-3-galactosyltransferase gene knockout (GalTKO) pig-to-baboon renal transplant model demonstrated that the early development of nephrotic syndrome has been a significant obstacle to the long-te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e666bfb1aca6982b1f71ae9e5c8503a0
https://europepmc.org/articles/PMC7007337/
https://europepmc.org/articles/PMC7007337/
Autor:
David Ayares, Yuichi Ariyoshi, Megan Sykes, Hisashi Sahara, Kazuhiko Yamada, Kazuhiro Takeuchi, Scott Arn, Lennan K Boyd, Thomas Pomposelli, Dilrukshi Ekanayake-Alper, Hironosuke Watanabe, Akira Shimizu, David H. Sachs, Marc I Lorber
Publikováno v:
Xenotransplantation
Background We have recently demonstrated that human-CD47 (hCD47) expressed on endothelial cells of porcine lung xenografts extended median graft survival from 3.5 days to 8.7 days in baboons. Intra-bone bone marrow transplantation (IBBMTx) in a pig-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ade2dc04f04150aba276aa6249269fd
https://pubmed.ncbi.nlm.nih.gov/31544995
https://pubmed.ncbi.nlm.nih.gov/31544995